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ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients

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ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients. / Adam, S Alexandra; Schnell, Oliver; Pöschl, Julia; Eigenbrod, Sabina; Kretzschmar, Hans A; Tonn, Jörg-Christian; Schüller, Ulrich.

In: BRAIN PATHOL, Vol. 22, No. 6, 11.2012, p. 788-97.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Adam, SA, Schnell, O, Pöschl, J, Eigenbrod, S, Kretzschmar, HA, Tonn, J-C & Schüller, U 2012, 'ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients', BRAIN PATHOL, vol. 22, no. 6, pp. 788-97. https://doi.org/10.1111/j.1750-3639.2012.00592.x

APA

Adam, S. A., Schnell, O., Pöschl, J., Eigenbrod, S., Kretzschmar, H. A., Tonn, J-C., & Schüller, U. (2012). ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients. BRAIN PATHOL, 22(6), 788-97. https://doi.org/10.1111/j.1750-3639.2012.00592.x

Vancouver

Adam SA, Schnell O, Pöschl J, Eigenbrod S, Kretzschmar HA, Tonn J-C et al. ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients. BRAIN PATHOL. 2012 Nov;22(6):788-97. https://doi.org/10.1111/j.1750-3639.2012.00592.x

Bibtex

@article{99cc9a42b47b444bb1d3ba35c9fe822b,
title = "ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients",
abstract = "Glioblastoma is the most common malignant brain tumor and patients usually succumb to their disease within 2 years. Aldehyde dehydrogenase 1A1 (ALDH1A1) has been suggested as a marker for cancer stem cells that is associated with poor prognosis in human gliomas. However, little is known about the expression and the function of ALDH1A1 in early stages of brain development. We analyzed ALDH1A1 expression in developing and mature central nervous system (CNS) as well as in 93 cases of primary glioblastomas. Surprisingly, ALDH1A1 was absent in the stem cell niches at varying stages of CNS development, but strong ALDH1A1 expression was observed in mature astrocytes coexpressing GFAP and S100. There were 92 out of 93 glioblastomas (99%) that showed ALDH1A1 protein expression in up to 49% of tumor cells. The majority of these cells co-expressed GFAP, but not established stem cell markers such as Nestin, OLIG2 or SOX2. Finally, strong expression of ALDH1A1 correlated with a significantly better survival of the patients and proved to be an independent prognostic marker in our series (P < 0.01). In contrast to other published data, we therefore provide evidence for ALDH1A1 as a marker of astrocytic differentiation during brain development and of better prognosis in patients suffering from primary glioblastoma.",
keywords = "Aldehyde Dehydrogenase, Astrocytes, Biomarkers, Tumor, Brain, Brain Neoplasms, Cell Differentiation, Disease-Free Survival, Fetus, Glioblastoma, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Middle Aged, Neurogenesis, Oligonucleotide Array Sequence Analysis, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Stem Cell Niche, Journal Article, Research Support, Non-U.S. Gov't",
author = "Adam, {S Alexandra} and Oliver Schnell and Julia P{\"o}schl and Sabina Eigenbrod and Kretzschmar, {Hans A} and J{\"o}rg-Christian Tonn and Ulrich Sch{\"u}ller",
note = "{\textcopyright} 2012 The Authors; Brain Pathology {\textcopyright} 2012 International Society of Neuropathology.",
year = "2012",
month = nov,
doi = "10.1111/j.1750-3639.2012.00592.x",
language = "English",
volume = "22",
pages = "788--97",
journal = "BRAIN PATHOL",
issn = "1015-6305",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients

AU - Adam, S Alexandra

AU - Schnell, Oliver

AU - Pöschl, Julia

AU - Eigenbrod, Sabina

AU - Kretzschmar, Hans A

AU - Tonn, Jörg-Christian

AU - Schüller, Ulrich

N1 - © 2012 The Authors; Brain Pathology © 2012 International Society of Neuropathology.

PY - 2012/11

Y1 - 2012/11

N2 - Glioblastoma is the most common malignant brain tumor and patients usually succumb to their disease within 2 years. Aldehyde dehydrogenase 1A1 (ALDH1A1) has been suggested as a marker for cancer stem cells that is associated with poor prognosis in human gliomas. However, little is known about the expression and the function of ALDH1A1 in early stages of brain development. We analyzed ALDH1A1 expression in developing and mature central nervous system (CNS) as well as in 93 cases of primary glioblastomas. Surprisingly, ALDH1A1 was absent in the stem cell niches at varying stages of CNS development, but strong ALDH1A1 expression was observed in mature astrocytes coexpressing GFAP and S100. There were 92 out of 93 glioblastomas (99%) that showed ALDH1A1 protein expression in up to 49% of tumor cells. The majority of these cells co-expressed GFAP, but not established stem cell markers such as Nestin, OLIG2 or SOX2. Finally, strong expression of ALDH1A1 correlated with a significantly better survival of the patients and proved to be an independent prognostic marker in our series (P < 0.01). In contrast to other published data, we therefore provide evidence for ALDH1A1 as a marker of astrocytic differentiation during brain development and of better prognosis in patients suffering from primary glioblastoma.

AB - Glioblastoma is the most common malignant brain tumor and patients usually succumb to their disease within 2 years. Aldehyde dehydrogenase 1A1 (ALDH1A1) has been suggested as a marker for cancer stem cells that is associated with poor prognosis in human gliomas. However, little is known about the expression and the function of ALDH1A1 in early stages of brain development. We analyzed ALDH1A1 expression in developing and mature central nervous system (CNS) as well as in 93 cases of primary glioblastomas. Surprisingly, ALDH1A1 was absent in the stem cell niches at varying stages of CNS development, but strong ALDH1A1 expression was observed in mature astrocytes coexpressing GFAP and S100. There were 92 out of 93 glioblastomas (99%) that showed ALDH1A1 protein expression in up to 49% of tumor cells. The majority of these cells co-expressed GFAP, but not established stem cell markers such as Nestin, OLIG2 or SOX2. Finally, strong expression of ALDH1A1 correlated with a significantly better survival of the patients and proved to be an independent prognostic marker in our series (P < 0.01). In contrast to other published data, we therefore provide evidence for ALDH1A1 as a marker of astrocytic differentiation during brain development and of better prognosis in patients suffering from primary glioblastoma.

KW - Aldehyde Dehydrogenase

KW - Astrocytes

KW - Biomarkers, Tumor

KW - Brain

KW - Brain Neoplasms

KW - Cell Differentiation

KW - Disease-Free Survival

KW - Fetus

KW - Glioblastoma

KW - Humans

KW - Immunohistochemistry

KW - Kaplan-Meier Estimate

KW - Middle Aged

KW - Neurogenesis

KW - Oligonucleotide Array Sequence Analysis

KW - Real-Time Polymerase Chain Reaction

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Stem Cell Niche

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/j.1750-3639.2012.00592.x

DO - 10.1111/j.1750-3639.2012.00592.x

M3 - SCORING: Journal article

C2 - 22417385

VL - 22

SP - 788

EP - 797

JO - BRAIN PATHOL

JF - BRAIN PATHOL

SN - 1015-6305

IS - 6

ER -