Alcoholic ingredients in skin disinfectants increase biofilm expression of Staphylococcus epidermidis.
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Alcoholic ingredients in skin disinfectants increase biofilm expression of Staphylococcus epidermidis. / Knobloch, Johannes K-M; Horstkotte, Matthias A; Rohde, Holger; Kaulfers, Paul-Michael; Mack, Dietrich.
In: J ANTIMICROB CHEMOTH, Vol. 49, No. 4, 4, 2002, p. 683-687.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Alcoholic ingredients in skin disinfectants increase biofilm expression of Staphylococcus epidermidis.
AU - Knobloch, Johannes K-M
AU - Horstkotte, Matthias A
AU - Rohde, Holger
AU - Kaulfers, Paul-Michael
AU - Mack, Dietrich
PY - 2002
Y1 - 2002
N2 - The pathogenesis of Staphylococcus epidermidis is correlated with biofilm formation. We investigated the effect of three common alcoholic skin disinfectants, ethanol, n-propanol and isopropanol, on the biofilm formation of 37 clinical, icaADBC-positive S. epidermidis isolates. In alcohol-supplemented media 18 strains displayed increased biofilm expression. Sixteen of 19 strains were generally incapable of biofilm formation. In three representative isolates, the increase in biofilm formation was paralleled by increased polysaccharide intercellular adhesin synthesis. Regarding the widespread use of alcoholic skin disinfectants, it is possible that the alcohol-inducible biofilm phenotype of S. epidermidis could add to the development of foreign body-related infections.
AB - The pathogenesis of Staphylococcus epidermidis is correlated with biofilm formation. We investigated the effect of three common alcoholic skin disinfectants, ethanol, n-propanol and isopropanol, on the biofilm formation of 37 clinical, icaADBC-positive S. epidermidis isolates. In alcohol-supplemented media 18 strains displayed increased biofilm expression. Sixteen of 19 strains were generally incapable of biofilm formation. In three representative isolates, the increase in biofilm formation was paralleled by increased polysaccharide intercellular adhesin synthesis. Regarding the widespread use of alcoholic skin disinfectants, it is possible that the alcohol-inducible biofilm phenotype of S. epidermidis could add to the development of foreign body-related infections.
U2 - 10.1093/jac/49.4.683
DO - 10.1093/jac/49.4.683
M3 - SCORING: Zeitschriftenaufsatz
VL - 49
SP - 683
EP - 687
JO - J ANTIMICROB CHEMOTH
JF - J ANTIMICROB CHEMOTH
SN - 0305-7453
IS - 4
M1 - 4
ER -