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Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study

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Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study. / Luppa, Melanie; Pabst, Alexander; Löbner, Margrit; Mallon, Tina; Brettschneider, Christian; Hajek, André; Heser, Kathrin; Kleineidam, Luca; Weyerer, Siegfried; Werle, Jochen; Pentzek, Michael; Weeg, Dagmar; Mösch, Edelgard; Wiese, Birgitt; Oey, Anke; Wagner, Michael; Maier, Wolfgang; Scherer, Martin; König, Hans-Helmut; Riedel-Heller, Steffi G.

In: FRONT PSYCHIATRY, Vol. 15, 11.06.2024, p. 1367225.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Luppa, M, Pabst, A, Löbner, M, Mallon, T, Brettschneider, C, Hajek, A, Heser, K, Kleineidam, L, Weyerer, S, Werle, J, Pentzek, M, Weeg, D, Mösch, E, Wiese, B, Oey, A, Wagner, M, Maier, W, Scherer, M, König, H-H & Riedel-Heller, SG 2024, 'Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study', FRONT PSYCHIATRY, vol. 15, pp. 1367225. https://doi.org/10.3389/fpsyt.2024.1367225

APA

Luppa, M., Pabst, A., Löbner, M., Mallon, T., Brettschneider, C., Hajek, A., Heser, K., Kleineidam, L., Weyerer, S., Werle, J., Pentzek, M., Weeg, D., Mösch, E., Wiese, B., Oey, A., Wagner, M., Maier, W., Scherer, M., König, H-H., & Riedel-Heller, S. G. (2024). Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study. FRONT PSYCHIATRY, 15, 1367225. https://doi.org/10.3389/fpsyt.2024.1367225

Vancouver

Luppa M, Pabst A, Löbner M, Mallon T, Brettschneider C, Hajek A et al. Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study. FRONT PSYCHIATRY. 2024 Jun 11;15:1367225. https://doi.org/10.3389/fpsyt.2024.1367225

Bibtex

@article{701c708639db46cd904e141e86ac9e1d,
title = "Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study",
abstract = "PURPOSE: The present study aimed to investigate age-group-specific incidence rates and risk factors for depressive symptoms in the highest age groups.METHODS: Data were derived from a prospective multicenter cohort study conducted in primary care - the AgeCoDe/AgeQualiDe study. In total, 2,436 patients 75 years and older were followed from baseline to ninth follow-up. To assess depressive symptoms, the short version of the Geriatric Depression Scale (GDS-15, cutoff score 6) was used. Age-specific competing risk regressions were performed to analyze risk factors for incident depressive symptoms in different age groups (75 to 79, 80 to 84, 85+ years), taking into account the accumulated mortality.RESULTS: The age-specific incidence rate of depression was 33 (95% CI 29-38), 46 (95% CI 40-52) and 63 (95% CI 45-87) per 1,000 person years for the initial age groups 75 to 79, 80 to 84 and 85+ years, respectively. In competing risk regression models, female sex, mobility as well as vision impairment, and subjective cognitive decline (SCD) were found to be risk factors for incident depression for age group 75 to 79, female sex, single/separated marital status, mobility as well as hearing impairment, and SCD for age group 80 to 84, and mobility impairment for age group 85+.CONCLUSION: Depressive symptoms in latest life are common and the incidence increases with increasing age. Modifiable and differing risk factors across the highest age groups open up the possibility of specifically tailored prevention concepts.",
author = "Melanie Luppa and Alexander Pabst and Margrit L{\"o}bner and Tina Mallon and Christian Brettschneider and Andr{\'e} Hajek and Kathrin Heser and Luca Kleineidam and Siegfried Weyerer and Jochen Werle and Michael Pentzek and Dagmar Weeg and Edelgard M{\"o}sch and Birgitt Wiese and Anke Oey and Michael Wagner and Wolfgang Maier and Martin Scherer and Hans-Helmut K{\"o}nig and Riedel-Heller, {Steffi G.}",
year = "2024",
month = jun,
day = "11",
doi = "10.3389/fpsyt.2024.1367225",
language = "English",
volume = "15",
pages = "1367225",
journal = "FRONT PSYCHIATRY",
issn = "1664-0640",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study

AU - Luppa, Melanie

AU - Pabst, Alexander

AU - Löbner, Margrit

AU - Mallon, Tina

AU - Brettschneider, Christian

AU - Hajek, André

AU - Heser, Kathrin

AU - Kleineidam, Luca

AU - Weyerer, Siegfried

AU - Werle, Jochen

AU - Pentzek, Michael

AU - Weeg, Dagmar

AU - Mösch, Edelgard

AU - Wiese, Birgitt

AU - Oey, Anke

AU - Wagner, Michael

AU - Maier, Wolfgang

AU - Scherer, Martin

AU - König, Hans-Helmut

AU - Riedel-Heller, Steffi G.

PY - 2024/6/11

Y1 - 2024/6/11

N2 - PURPOSE: The present study aimed to investigate age-group-specific incidence rates and risk factors for depressive symptoms in the highest age groups.METHODS: Data were derived from a prospective multicenter cohort study conducted in primary care - the AgeCoDe/AgeQualiDe study. In total, 2,436 patients 75 years and older were followed from baseline to ninth follow-up. To assess depressive symptoms, the short version of the Geriatric Depression Scale (GDS-15, cutoff score 6) was used. Age-specific competing risk regressions were performed to analyze risk factors for incident depressive symptoms in different age groups (75 to 79, 80 to 84, 85+ years), taking into account the accumulated mortality.RESULTS: The age-specific incidence rate of depression was 33 (95% CI 29-38), 46 (95% CI 40-52) and 63 (95% CI 45-87) per 1,000 person years for the initial age groups 75 to 79, 80 to 84 and 85+ years, respectively. In competing risk regression models, female sex, mobility as well as vision impairment, and subjective cognitive decline (SCD) were found to be risk factors for incident depression for age group 75 to 79, female sex, single/separated marital status, mobility as well as hearing impairment, and SCD for age group 80 to 84, and mobility impairment for age group 85+.CONCLUSION: Depressive symptoms in latest life are common and the incidence increases with increasing age. Modifiable and differing risk factors across the highest age groups open up the possibility of specifically tailored prevention concepts.

AB - PURPOSE: The present study aimed to investigate age-group-specific incidence rates and risk factors for depressive symptoms in the highest age groups.METHODS: Data were derived from a prospective multicenter cohort study conducted in primary care - the AgeCoDe/AgeQualiDe study. In total, 2,436 patients 75 years and older were followed from baseline to ninth follow-up. To assess depressive symptoms, the short version of the Geriatric Depression Scale (GDS-15, cutoff score 6) was used. Age-specific competing risk regressions were performed to analyze risk factors for incident depressive symptoms in different age groups (75 to 79, 80 to 84, 85+ years), taking into account the accumulated mortality.RESULTS: The age-specific incidence rate of depression was 33 (95% CI 29-38), 46 (95% CI 40-52) and 63 (95% CI 45-87) per 1,000 person years for the initial age groups 75 to 79, 80 to 84 and 85+ years, respectively. In competing risk regression models, female sex, mobility as well as vision impairment, and subjective cognitive decline (SCD) were found to be risk factors for incident depression for age group 75 to 79, female sex, single/separated marital status, mobility as well as hearing impairment, and SCD for age group 80 to 84, and mobility impairment for age group 85+.CONCLUSION: Depressive symptoms in latest life are common and the incidence increases with increasing age. Modifiable and differing risk factors across the highest age groups open up the possibility of specifically tailored prevention concepts.

U2 - 10.3389/fpsyt.2024.1367225

DO - 10.3389/fpsyt.2024.1367225

M3 - SCORING: Journal article

VL - 15

SP - 1367225

JO - FRONT PSYCHIATRY

JF - FRONT PSYCHIATRY

SN - 1664-0640

ER -