Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study
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Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study. / Luppa, Melanie; Pabst, Alexander; Löbner, Margrit; Mallon, Tina; Brettschneider, Christian; Hajek, André; Heser, Kathrin; Kleineidam, Luca; Weyerer, Siegfried; Werle, Jochen; Pentzek, Michael; Weeg, Dagmar; Mösch, Edelgard; Wiese, Birgitt; Oey, Anke; Wagner, Michael; Maier, Wolfgang; Scherer, Martin; König, Hans-Helmut; Riedel-Heller, Steffi G.
in: FRONT PSYCHIATRY, Jahrgang 15, 11.06.2024, S. 1367225.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study
AU - Luppa, Melanie
AU - Pabst, Alexander
AU - Löbner, Margrit
AU - Mallon, Tina
AU - Brettschneider, Christian
AU - Hajek, André
AU - Heser, Kathrin
AU - Kleineidam, Luca
AU - Weyerer, Siegfried
AU - Werle, Jochen
AU - Pentzek, Michael
AU - Weeg, Dagmar
AU - Mösch, Edelgard
AU - Wiese, Birgitt
AU - Oey, Anke
AU - Wagner, Michael
AU - Maier, Wolfgang
AU - Scherer, Martin
AU - König, Hans-Helmut
AU - Riedel-Heller, Steffi G.
PY - 2024/6/11
Y1 - 2024/6/11
N2 - PURPOSE: The present study aimed to investigate age-group-specific incidence rates and risk factors for depressive symptoms in the highest age groups.METHODS: Data were derived from a prospective multicenter cohort study conducted in primary care - the AgeCoDe/AgeQualiDe study. In total, 2,436 patients 75 years and older were followed from baseline to ninth follow-up. To assess depressive symptoms, the short version of the Geriatric Depression Scale (GDS-15, cutoff score 6) was used. Age-specific competing risk regressions were performed to analyze risk factors for incident depressive symptoms in different age groups (75 to 79, 80 to 84, 85+ years), taking into account the accumulated mortality.RESULTS: The age-specific incidence rate of depression was 33 (95% CI 29-38), 46 (95% CI 40-52) and 63 (95% CI 45-87) per 1,000 person years for the initial age groups 75 to 79, 80 to 84 and 85+ years, respectively. In competing risk regression models, female sex, mobility as well as vision impairment, and subjective cognitive decline (SCD) were found to be risk factors for incident depression for age group 75 to 79, female sex, single/separated marital status, mobility as well as hearing impairment, and SCD for age group 80 to 84, and mobility impairment for age group 85+.CONCLUSION: Depressive symptoms in latest life are common and the incidence increases with increasing age. Modifiable and differing risk factors across the highest age groups open up the possibility of specifically tailored prevention concepts.
AB - PURPOSE: The present study aimed to investigate age-group-specific incidence rates and risk factors for depressive symptoms in the highest age groups.METHODS: Data were derived from a prospective multicenter cohort study conducted in primary care - the AgeCoDe/AgeQualiDe study. In total, 2,436 patients 75 years and older were followed from baseline to ninth follow-up. To assess depressive symptoms, the short version of the Geriatric Depression Scale (GDS-15, cutoff score 6) was used. Age-specific competing risk regressions were performed to analyze risk factors for incident depressive symptoms in different age groups (75 to 79, 80 to 84, 85+ years), taking into account the accumulated mortality.RESULTS: The age-specific incidence rate of depression was 33 (95% CI 29-38), 46 (95% CI 40-52) and 63 (95% CI 45-87) per 1,000 person years for the initial age groups 75 to 79, 80 to 84 and 85+ years, respectively. In competing risk regression models, female sex, mobility as well as vision impairment, and subjective cognitive decline (SCD) were found to be risk factors for incident depression for age group 75 to 79, female sex, single/separated marital status, mobility as well as hearing impairment, and SCD for age group 80 to 84, and mobility impairment for age group 85+.CONCLUSION: Depressive symptoms in latest life are common and the incidence increases with increasing age. Modifiable and differing risk factors across the highest age groups open up the possibility of specifically tailored prevention concepts.
U2 - 10.3389/fpsyt.2024.1367225
DO - 10.3389/fpsyt.2024.1367225
M3 - SCORING: Journal article
VL - 15
SP - 1367225
JO - FRONT PSYCHIATRY
JF - FRONT PSYCHIATRY
SN - 1664-0640
ER -