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Acute psychological stress alerts the adaptive immune response

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Acute psychological stress alerts the adaptive immune response : stress-induced mobilization of effector T cells. / Atanackovic, Djordje; Schnee, Benjamin; Schuch, Gunter; Faltz, Christiane; Schulze, Julia; Weber, Cora S; Schafhausen, Philippe; Bartels, Katrin; Bokemeyer, Carsten; Brunner-Weinzierl, Monika Christine; Deter, Hans-Christian.

In: J NEUROIMMUNOL, Vol. 176, No. 1-2, 07.2006, p. 141-52.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Atanackovic, D, Schnee, B, Schuch, G, Faltz, C, Schulze, J, Weber, CS, Schafhausen, P, Bartels, K, Bokemeyer, C, Brunner-Weinzierl, MC & Deter, H-C 2006, 'Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells', J NEUROIMMUNOL, vol. 176, no. 1-2, pp. 141-52. https://doi.org/10.1016/j.jneuroim.2006.03.023

APA

Atanackovic, D., Schnee, B., Schuch, G., Faltz, C., Schulze, J., Weber, C. S., Schafhausen, P., Bartels, K., Bokemeyer, C., Brunner-Weinzierl, M. C., & Deter, H-C. (2006). Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells. J NEUROIMMUNOL, 176(1-2), 141-52. https://doi.org/10.1016/j.jneuroim.2006.03.023

Vancouver

Atanackovic D, Schnee B, Schuch G, Faltz C, Schulze J, Weber CS et al. Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells. J NEUROIMMUNOL. 2006 Jul;176(1-2):141-52. https://doi.org/10.1016/j.jneuroim.2006.03.023

Bibtex

@article{03091639592f4a34ab9a7bfb398a46dd,
title = "Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells",
abstract = "Influences of psychological stress on the acquired immune system have not consequently been investigated. We found acute psychological stress to cause an increase in CD56+ and CCR5+ effector T cells in the peripheral blood of healthy human subjects (N=22), while skin-homing CLA+ T cells decreased. At the same time, we observed a stress-induced decrease in CD45RA+/CCR7+ naive and CD45RA-/CCR7+ central memory T cells, while CD45RA-/CCR7- effector memory and CD45RA+/CCR7- terminally differentiated T cells increased. This T cell redistribution translated into an increase in T cells expressing perforin/granzyme B and in Epstein-Barr virus-specific, cytomegalovirus-specific and influenza virus-specific CD8+ T cells. Thus, acute stress seems to promote the retention of less mature T cells within lymphoid tissue or skin while effector-type T cells are mobilized into the blood in order to be able to rapidly migrate into peripheral tissues.",
keywords = "Acute Disease, Adult, Antigens, CD45, Antigens, CD56, Antigens, Differentiation, T-Lymphocyte, Antigens, Neoplasm, Cell Movement, Humans, Immunologic Memory, Killer Cells, Natural, Male, Membrane Glycoproteins, Receptors, CCR5, Receptors, CCR7, Receptors, Chemokine, Stress, Psychological, T-Lymphocytes",
author = "Djordje Atanackovic and Benjamin Schnee and Gunter Schuch and Christiane Faltz and Julia Schulze and Weber, {Cora S} and Philippe Schafhausen and Katrin Bartels and Carsten Bokemeyer and Brunner-Weinzierl, {Monika Christine} and Hans-Christian Deter",
year = "2006",
month = jul,
doi = "10.1016/j.jneuroim.2006.03.023",
language = "English",
volume = "176",
pages = "141--52",
journal = "J NEUROIMMUNOL",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Acute psychological stress alerts the adaptive immune response

T2 - stress-induced mobilization of effector T cells

AU - Atanackovic, Djordje

AU - Schnee, Benjamin

AU - Schuch, Gunter

AU - Faltz, Christiane

AU - Schulze, Julia

AU - Weber, Cora S

AU - Schafhausen, Philippe

AU - Bartels, Katrin

AU - Bokemeyer, Carsten

AU - Brunner-Weinzierl, Monika Christine

AU - Deter, Hans-Christian

PY - 2006/7

Y1 - 2006/7

N2 - Influences of psychological stress on the acquired immune system have not consequently been investigated. We found acute psychological stress to cause an increase in CD56+ and CCR5+ effector T cells in the peripheral blood of healthy human subjects (N=22), while skin-homing CLA+ T cells decreased. At the same time, we observed a stress-induced decrease in CD45RA+/CCR7+ naive and CD45RA-/CCR7+ central memory T cells, while CD45RA-/CCR7- effector memory and CD45RA+/CCR7- terminally differentiated T cells increased. This T cell redistribution translated into an increase in T cells expressing perforin/granzyme B and in Epstein-Barr virus-specific, cytomegalovirus-specific and influenza virus-specific CD8+ T cells. Thus, acute stress seems to promote the retention of less mature T cells within lymphoid tissue or skin while effector-type T cells are mobilized into the blood in order to be able to rapidly migrate into peripheral tissues.

AB - Influences of psychological stress on the acquired immune system have not consequently been investigated. We found acute psychological stress to cause an increase in CD56+ and CCR5+ effector T cells in the peripheral blood of healthy human subjects (N=22), while skin-homing CLA+ T cells decreased. At the same time, we observed a stress-induced decrease in CD45RA+/CCR7+ naive and CD45RA-/CCR7+ central memory T cells, while CD45RA-/CCR7- effector memory and CD45RA+/CCR7- terminally differentiated T cells increased. This T cell redistribution translated into an increase in T cells expressing perforin/granzyme B and in Epstein-Barr virus-specific, cytomegalovirus-specific and influenza virus-specific CD8+ T cells. Thus, acute stress seems to promote the retention of less mature T cells within lymphoid tissue or skin while effector-type T cells are mobilized into the blood in order to be able to rapidly migrate into peripheral tissues.

KW - Acute Disease

KW - Adult

KW - Antigens, CD45

KW - Antigens, CD56

KW - Antigens, Differentiation, T-Lymphocyte

KW - Antigens, Neoplasm

KW - Cell Movement

KW - Humans

KW - Immunologic Memory

KW - Killer Cells, Natural

KW - Male

KW - Membrane Glycoproteins

KW - Receptors, CCR5

KW - Receptors, CCR7

KW - Receptors, Chemokine

KW - Stress, Psychological

KW - T-Lymphocytes

U2 - 10.1016/j.jneuroim.2006.03.023

DO - 10.1016/j.jneuroim.2006.03.023

M3 - SCORING: Journal article

C2 - 16712956

VL - 176

SP - 141

EP - 152

JO - J NEUROIMMUNOL

JF - J NEUROIMMUNOL

SN - 0165-5728

IS - 1-2

ER -