Acute psychological stress alerts the adaptive immune response
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Acute psychological stress alerts the adaptive immune response : stress-induced mobilization of effector T cells. / Atanackovic, Djordje; Schnee, Benjamin; Schuch, Gunter; Faltz, Christiane; Schulze, Julia; Weber, Cora S; Schafhausen, Philippe; Bartels, Katrin; Bokemeyer, Carsten; Brunner-Weinzierl, Monika Christine; Deter, Hans-Christian.
in: J NEUROIMMUNOL, Jahrgang 176, Nr. 1-2, 07.2006, S. 141-52.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Acute psychological stress alerts the adaptive immune response
T2 - stress-induced mobilization of effector T cells
AU - Atanackovic, Djordje
AU - Schnee, Benjamin
AU - Schuch, Gunter
AU - Faltz, Christiane
AU - Schulze, Julia
AU - Weber, Cora S
AU - Schafhausen, Philippe
AU - Bartels, Katrin
AU - Bokemeyer, Carsten
AU - Brunner-Weinzierl, Monika Christine
AU - Deter, Hans-Christian
PY - 2006/7
Y1 - 2006/7
N2 - Influences of psychological stress on the acquired immune system have not consequently been investigated. We found acute psychological stress to cause an increase in CD56+ and CCR5+ effector T cells in the peripheral blood of healthy human subjects (N=22), while skin-homing CLA+ T cells decreased. At the same time, we observed a stress-induced decrease in CD45RA+/CCR7+ naive and CD45RA-/CCR7+ central memory T cells, while CD45RA-/CCR7- effector memory and CD45RA+/CCR7- terminally differentiated T cells increased. This T cell redistribution translated into an increase in T cells expressing perforin/granzyme B and in Epstein-Barr virus-specific, cytomegalovirus-specific and influenza virus-specific CD8+ T cells. Thus, acute stress seems to promote the retention of less mature T cells within lymphoid tissue or skin while effector-type T cells are mobilized into the blood in order to be able to rapidly migrate into peripheral tissues.
AB - Influences of psychological stress on the acquired immune system have not consequently been investigated. We found acute psychological stress to cause an increase in CD56+ and CCR5+ effector T cells in the peripheral blood of healthy human subjects (N=22), while skin-homing CLA+ T cells decreased. At the same time, we observed a stress-induced decrease in CD45RA+/CCR7+ naive and CD45RA-/CCR7+ central memory T cells, while CD45RA-/CCR7- effector memory and CD45RA+/CCR7- terminally differentiated T cells increased. This T cell redistribution translated into an increase in T cells expressing perforin/granzyme B and in Epstein-Barr virus-specific, cytomegalovirus-specific and influenza virus-specific CD8+ T cells. Thus, acute stress seems to promote the retention of less mature T cells within lymphoid tissue or skin while effector-type T cells are mobilized into the blood in order to be able to rapidly migrate into peripheral tissues.
KW - Acute Disease
KW - Adult
KW - Antigens, CD45
KW - Antigens, CD56
KW - Antigens, Differentiation, T-Lymphocyte
KW - Antigens, Neoplasm
KW - Cell Movement
KW - Humans
KW - Immunologic Memory
KW - Killer Cells, Natural
KW - Male
KW - Membrane Glycoproteins
KW - Receptors, CCR5
KW - Receptors, CCR7
KW - Receptors, Chemokine
KW - Stress, Psychological
KW - T-Lymphocytes
U2 - 10.1016/j.jneuroim.2006.03.023
DO - 10.1016/j.jneuroim.2006.03.023
M3 - SCORING: Journal article
C2 - 16712956
VL - 176
SP - 141
EP - 152
JO - J NEUROIMMUNOL
JF - J NEUROIMMUNOL
SN - 0165-5728
IS - 1-2
ER -