Actomyosin Contractility in the Generation and Plasticity of Axons and Dendritic Spines
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Actomyosin Contractility in the Generation and Plasticity of Axons and Dendritic Spines. / Mikhaylova, Marina; Rentsch, Jakob; Ewers, Helge.
In: CELLS-BASEL, Vol. 9, No. 9, 01.09.2020.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Actomyosin Contractility in the Generation and Plasticity of Axons and Dendritic Spines
AU - Mikhaylova, Marina
AU - Rentsch, Jakob
AU - Ewers, Helge
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible roles of actomyosin contraction in organizing and maintaining structural properties of dendritic spines, the size and location of axon initial segment and axonal diameter are emerging research topics. In this review, we aim to summarize recent findings involving myosin localization and function in these compartments and to discuss possible roles for actomyosin in their function and the signaling pathways that control them.
AB - Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible roles of actomyosin contraction in organizing and maintaining structural properties of dendritic spines, the size and location of axon initial segment and axonal diameter are emerging research topics. In this review, we aim to summarize recent findings involving myosin localization and function in these compartments and to discuss possible roles for actomyosin in their function and the signaling pathways that control them.
U2 - 10.3390/cells9092006
DO - 10.3390/cells9092006
M3 - SCORING: Review article
C2 - 32882840
VL - 9
JO - CELLS-BASEL
JF - CELLS-BASEL
SN - 2073-4409
IS - 9
ER -