Activity modulation of the bacterial Rho GAP YopE: an inspiration for the investigation of mammalian Rho GAPs.
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Activity modulation of the bacterial Rho GAP YopE: an inspiration for the investigation of mammalian Rho GAPs. / Aepfelbacher, Martin; Roppenser, Bernhard; Hentschke, Moritz; Ruckdeschel, Klaus.
In: EUR J CELL BIOL, Vol. 90, No. 11, 11, 2011, p. 951-954.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Activity modulation of the bacterial Rho GAP YopE: an inspiration for the investigation of mammalian Rho GAPs.
AU - Aepfelbacher, Martin
AU - Roppenser, Bernhard
AU - Hentschke, Moritz
AU - Ruckdeschel, Klaus
PY - 2011
Y1 - 2011
N2 - The Yersinia enterocolitica Rho GTPase Activating Protein (Rho GAP) YopE belongs to a group of bacterial virulence factors that is translocated into infected target cells by a type three secretion system. Structurally and biochemically YopE resembles eukaryotic Rho GAPs which control various cellular functions by modulating the activity of Rho GTP binding proteins. Here we summarise the published information on cellular effects, Rho protein substrates, compartmentalisation and turnover of YopE. A fascinating picture evolves of how this virulence factor integrates in host cellular regulatory mechanisms to fine tune bacterial pathogenicity.
AB - The Yersinia enterocolitica Rho GTPase Activating Protein (Rho GAP) YopE belongs to a group of bacterial virulence factors that is translocated into infected target cells by a type three secretion system. Structurally and biochemically YopE resembles eukaryotic Rho GAPs which control various cellular functions by modulating the activity of Rho GTP binding proteins. Here we summarise the published information on cellular effects, Rho protein substrates, compartmentalisation and turnover of YopE. A fascinating picture evolves of how this virulence factor integrates in host cellular regulatory mechanisms to fine tune bacterial pathogenicity.
KW - Animals
KW - Humans
KW - Ubiquitination
KW - Bacterial Outer Membrane Proteins/chemistry/metabolism
KW - Bacterial Toxins/metabolism
KW - GTPase-Activating Proteins/chemistry/metabolism
KW - Yersinia enterocolitica/metabolism
KW - rho GTP-Binding Proteins/metabolism
KW - Animals
KW - Humans
KW - Ubiquitination
KW - Bacterial Outer Membrane Proteins/chemistry/metabolism
KW - Bacterial Toxins/metabolism
KW - GTPase-Activating Proteins/chemistry/metabolism
KW - Yersinia enterocolitica/metabolism
KW - rho GTP-Binding Proteins/metabolism
M3 - SCORING: Journal article
VL - 90
SP - 951
EP - 954
JO - EUR J CELL BIOL
JF - EUR J CELL BIOL
SN - 0171-9335
IS - 11
M1 - 11
ER -