Active cortical dendrites modulate perception
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Active cortical dendrites modulate perception. / Takahashi, Naoya; Oertner, Thomas G; Hegemann, Peter; Larkum, Matthew E.
In: SCIENCE, Vol. 354, No. 6319, 23.12.2016, p. 1587-1590.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Active cortical dendrites modulate perception
AU - Takahashi, Naoya
AU - Oertner, Thomas G
AU - Hegemann, Peter
AU - Larkum, Matthew E
N1 - Copyright © 2016, American Association for the Advancement of Science.
PY - 2016/12/23
Y1 - 2016/12/23
N2 - There is as yet no consensus concerning the neural basis of perception and how it operates at a mechanistic level. We found that Ca(2+) activity in the apical dendrites of a subset of layer 5 (L5) pyramidal neurons in primary somatosensory cortex (S1) in mice is correlated with the threshold for perceptual detection of whisker deflections. Manipulating the activity of apical dendrites shifted the perceptual threshold, demonstrating that an active dendritic mechanism is causally linked to perceptual detection.
AB - There is as yet no consensus concerning the neural basis of perception and how it operates at a mechanistic level. We found that Ca(2+) activity in the apical dendrites of a subset of layer 5 (L5) pyramidal neurons in primary somatosensory cortex (S1) in mice is correlated with the threshold for perceptual detection of whisker deflections. Manipulating the activity of apical dendrites shifted the perceptual threshold, demonstrating that an active dendritic mechanism is causally linked to perceptual detection.
U2 - 10.1126/science.aah6066
DO - 10.1126/science.aah6066
M3 - SCORING: Journal article
C2 - 28008068
VL - 354
SP - 1587
EP - 1590
JO - SCIENCE
JF - SCIENCE
SN - 0036-8075
IS - 6319
ER -