Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.
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Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. / Andres-Mateos, Eva; Brinkmeier, Heinrich; Burks, Tyesha N; Mejias, Rebeca; Files, Daniel C; Steinberger, Martin; Soleimani, Arshia; Marx, Ruth; Simmers, Jessica L; Lin, Benjamin; Erika, Finanger Hedderick; Marr, Tom G; Lin, Brian M; Hourdé, Christophe; Leinwand, Leslie A; Kuhl, Dietmar; Föller, Michael; Vogelsang, Silke; Hernandez-Diaz, Ivan; Vaughan, Dana K; Diego, Alvarez de La Rosa; Lang, Florian; Cohn, Ronald D.
In: EMBO MOL MED, Vol. 5, No. 1, 1, 2013, p. 80-91.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.
AU - Andres-Mateos, Eva
AU - Brinkmeier, Heinrich
AU - Burks, Tyesha N
AU - Mejias, Rebeca
AU - Files, Daniel C
AU - Steinberger, Martin
AU - Soleimani, Arshia
AU - Marx, Ruth
AU - Simmers, Jessica L
AU - Lin, Benjamin
AU - Erika, Finanger Hedderick
AU - Marr, Tom G
AU - Lin, Brian M
AU - Hourdé, Christophe
AU - Leinwand, Leslie A
AU - Kuhl, Dietmar
AU - Föller, Michael
AU - Vogelsang, Silke
AU - Hernandez-Diaz, Ivan
AU - Vaughan, Dana K
AU - Diego, Alvarez de La Rosa
AU - Lang, Florian
AU - Cohn, Ronald D
PY - 2013
Y1 - 2013
N2 - Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from muscle atrophy despite prolonged periods of immobilization and starvation. Here, we describe a mechanism underlying muscle preservation and translate it to non-hibernating mammals. Although Akt has an established role in skeletal muscle homeostasis, we find that serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates muscle mass maintenance via downregulation of proteolysis and autophagy as well as increased protein synthesis during hibernation. We demonstrate that SGK1 is critical for the maintenance of skeletal muscle homeostasis and function in non-hibernating mammals in normal and atrophic conditions such as starvation and immobilization. Our results identify a novel therapeutic target to combat loss of skeletal muscle mass associated with muscle degeneration and atrophy.
AB - Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from muscle atrophy despite prolonged periods of immobilization and starvation. Here, we describe a mechanism underlying muscle preservation and translate it to non-hibernating mammals. Although Akt has an established role in skeletal muscle homeostasis, we find that serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates muscle mass maintenance via downregulation of proteolysis and autophagy as well as increased protein synthesis during hibernation. We demonstrate that SGK1 is critical for the maintenance of skeletal muscle homeostasis and function in non-hibernating mammals in normal and atrophic conditions such as starvation and immobilization. Our results identify a novel therapeutic target to combat loss of skeletal muscle mass associated with muscle degeneration and atrophy.
KW - Animals
KW - Male
KW - Female
KW - Mice
KW - Base Sequence
KW - Signal Transduction
KW - Mice, Transgenic
KW - Enzyme Activation
KW - Homeostasis
KW - Proto-Oncogene Proteins c-akt/metabolism
KW - DNA Primers/genetics
KW - TOR Serine-Threonine Kinases/metabolism
KW - Immediate-Early Proteins/genetics/metabolism
KW - Protein-Serine-Threonine Kinases/genetics/metabolism
KW - Forkhead Transcription Factors/antagonists & inhibitors
KW - Hibernation/physiology
KW - Muscle, Skeletal/enzymology/pathology/physiopathology
KW - Muscular Atrophy/pathology/physiopathology/prevention & control
KW - Sciuridae
KW - Starvation/enzymology/pathology
KW - Animals
KW - Male
KW - Female
KW - Mice
KW - Base Sequence
KW - Signal Transduction
KW - Mice, Transgenic
KW - Enzyme Activation
KW - Homeostasis
KW - Proto-Oncogene Proteins c-akt/metabolism
KW - DNA Primers/genetics
KW - TOR Serine-Threonine Kinases/metabolism
KW - Immediate-Early Proteins/genetics/metabolism
KW - Protein-Serine-Threonine Kinases/genetics/metabolism
KW - Forkhead Transcription Factors/antagonists & inhibitors
KW - Hibernation/physiology
KW - Muscle, Skeletal/enzymology/pathology/physiopathology
KW - Muscular Atrophy/pathology/physiopathology/prevention & control
KW - Sciuridae
KW - Starvation/enzymology/pathology
U2 - 10.1002/emmm.201201443
DO - 10.1002/emmm.201201443
M3 - SCORING: Journal article
VL - 5
SP - 80
EP - 91
JO - EMBO MOL MED
JF - EMBO MOL MED
SN - 1757-4676
IS - 1
M1 - 1
ER -