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Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.

Standard

Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. / Andres-Mateos, Eva; Brinkmeier, Heinrich; Burks, Tyesha N; Mejias, Rebeca; Files, Daniel C; Steinberger, Martin; Soleimani, Arshia; Marx, Ruth; Simmers, Jessica L; Lin, Benjamin; Erika, Finanger Hedderick; Marr, Tom G; Lin, Brian M; Hourdé, Christophe; Leinwand, Leslie A; Kuhl, Dietmar; Föller, Michael; Vogelsang, Silke; Hernandez-Diaz, Ivan; Vaughan, Dana K; Diego, Alvarez de La Rosa; Lang, Florian; Cohn, Ronald D.

in: EMBO MOL MED, Jahrgang 5, Nr. 1, 1, 2013, S. 80-91.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Andres-Mateos, E, Brinkmeier, H, Burks, TN, Mejias, R, Files, DC, Steinberger, M, Soleimani, A, Marx, R, Simmers, JL, Lin, B, Erika, FH, Marr, TG, Lin, BM, Hourdé, C, Leinwand, LA, Kuhl, D, Föller, M, Vogelsang, S, Hernandez-Diaz, I, Vaughan, DK, Diego, ADLR, Lang, F & Cohn, RD 2013, 'Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.', EMBO MOL MED, Jg. 5, Nr. 1, 1, S. 80-91. https://doi.org/10.1002/emmm.201201443

APA

Andres-Mateos, E., Brinkmeier, H., Burks, T. N., Mejias, R., Files, D. C., Steinberger, M., Soleimani, A., Marx, R., Simmers, J. L., Lin, B., Erika, F. H., Marr, T. G., Lin, B. M., Hourdé, C., Leinwand, L. A., Kuhl, D., Föller, M., Vogelsang, S., Hernandez-Diaz, I., ... Cohn, R. D. (2013). Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO MOL MED, 5(1), 80-91. [1]. https://doi.org/10.1002/emmm.201201443

Vancouver

Andres-Mateos E, Brinkmeier H, Burks TN, Mejias R, Files DC, Steinberger M et al. Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO MOL MED. 2013;5(1):80-91. 1. https://doi.org/10.1002/emmm.201201443

Bibtex

@article{bdcc0ba08f1840ec97e69472d14ac01a,
title = "Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.",
abstract = "Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from muscle atrophy despite prolonged periods of immobilization and starvation. Here, we describe a mechanism underlying muscle preservation and translate it to non-hibernating mammals. Although Akt has an established role in skeletal muscle homeostasis, we find that serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates muscle mass maintenance via downregulation of proteolysis and autophagy as well as increased protein synthesis during hibernation. We demonstrate that SGK1 is critical for the maintenance of skeletal muscle homeostasis and function in non-hibernating mammals in normal and atrophic conditions such as starvation and immobilization. Our results identify a novel therapeutic target to combat loss of skeletal muscle mass associated with muscle degeneration and atrophy.",
keywords = "Animals, Male, Female, Mice, Base Sequence, Signal Transduction, Mice, Transgenic, Enzyme Activation, Homeostasis, Proto-Oncogene Proteins c-akt/metabolism, DNA Primers/genetics, TOR Serine-Threonine Kinases/metabolism, Immediate-Early Proteins/genetics/*metabolism, Protein-Serine-Threonine Kinases/genetics/*metabolism, Forkhead Transcription Factors/antagonists & inhibitors, Hibernation/physiology, Muscle, Skeletal/*enzymology/pathology/physiopathology, Muscular Atrophy/pathology/physiopathology/*prevention & control, Sciuridae, Starvation/enzymology/pathology, Animals, Male, Female, Mice, Base Sequence, Signal Transduction, Mice, Transgenic, Enzyme Activation, Homeostasis, Proto-Oncogene Proteins c-akt/metabolism, DNA Primers/genetics, TOR Serine-Threonine Kinases/metabolism, Immediate-Early Proteins/genetics/*metabolism, Protein-Serine-Threonine Kinases/genetics/*metabolism, Forkhead Transcription Factors/antagonists & inhibitors, Hibernation/physiology, Muscle, Skeletal/*enzymology/pathology/physiopathology, Muscular Atrophy/pathology/physiopathology/*prevention & control, Sciuridae, Starvation/enzymology/pathology",
author = "Eva Andres-Mateos and Heinrich Brinkmeier and Burks, {Tyesha N} and Rebeca Mejias and Files, {Daniel C} and Martin Steinberger and Arshia Soleimani and Ruth Marx and Simmers, {Jessica L} and Benjamin Lin and Erika, {Finanger Hedderick} and Marr, {Tom G} and Lin, {Brian M} and Christophe Hourd{\'e} and Leinwand, {Leslie A} and Dietmar Kuhl and Michael F{\"o}ller and Silke Vogelsang and Ivan Hernandez-Diaz and Vaughan, {Dana K} and Diego, {Alvarez de La Rosa} and Florian Lang and Cohn, {Ronald D}",
year = "2013",
doi = "10.1002/emmm.201201443",
language = "English",
volume = "5",
pages = "80--91",
journal = "EMBO MOL MED",
issn = "1757-4676",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.

AU - Andres-Mateos, Eva

AU - Brinkmeier, Heinrich

AU - Burks, Tyesha N

AU - Mejias, Rebeca

AU - Files, Daniel C

AU - Steinberger, Martin

AU - Soleimani, Arshia

AU - Marx, Ruth

AU - Simmers, Jessica L

AU - Lin, Benjamin

AU - Erika, Finanger Hedderick

AU - Marr, Tom G

AU - Lin, Brian M

AU - Hourdé, Christophe

AU - Leinwand, Leslie A

AU - Kuhl, Dietmar

AU - Föller, Michael

AU - Vogelsang, Silke

AU - Hernandez-Diaz, Ivan

AU - Vaughan, Dana K

AU - Diego, Alvarez de La Rosa

AU - Lang, Florian

AU - Cohn, Ronald D

PY - 2013

Y1 - 2013

N2 - Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from muscle atrophy despite prolonged periods of immobilization and starvation. Here, we describe a mechanism underlying muscle preservation and translate it to non-hibernating mammals. Although Akt has an established role in skeletal muscle homeostasis, we find that serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates muscle mass maintenance via downregulation of proteolysis and autophagy as well as increased protein synthesis during hibernation. We demonstrate that SGK1 is critical for the maintenance of skeletal muscle homeostasis and function in non-hibernating mammals in normal and atrophic conditions such as starvation and immobilization. Our results identify a novel therapeutic target to combat loss of skeletal muscle mass associated with muscle degeneration and atrophy.

AB - Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from muscle atrophy despite prolonged periods of immobilization and starvation. Here, we describe a mechanism underlying muscle preservation and translate it to non-hibernating mammals. Although Akt has an established role in skeletal muscle homeostasis, we find that serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates muscle mass maintenance via downregulation of proteolysis and autophagy as well as increased protein synthesis during hibernation. We demonstrate that SGK1 is critical for the maintenance of skeletal muscle homeostasis and function in non-hibernating mammals in normal and atrophic conditions such as starvation and immobilization. Our results identify a novel therapeutic target to combat loss of skeletal muscle mass associated with muscle degeneration and atrophy.

KW - Animals

KW - Male

KW - Female

KW - Mice

KW - Base Sequence

KW - Signal Transduction

KW - Mice, Transgenic

KW - Enzyme Activation

KW - Homeostasis

KW - Proto-Oncogene Proteins c-akt/metabolism

KW - DNA Primers/genetics

KW - TOR Serine-Threonine Kinases/metabolism

KW - Immediate-Early Proteins/genetics/metabolism

KW - Protein-Serine-Threonine Kinases/genetics/metabolism

KW - Forkhead Transcription Factors/antagonists & inhibitors

KW - Hibernation/physiology

KW - Muscle, Skeletal/enzymology/pathology/physiopathology

KW - Muscular Atrophy/pathology/physiopathology/prevention & control

KW - Sciuridae

KW - Starvation/enzymology/pathology

KW - Animals

KW - Male

KW - Female

KW - Mice

KW - Base Sequence

KW - Signal Transduction

KW - Mice, Transgenic

KW - Enzyme Activation

KW - Homeostasis

KW - Proto-Oncogene Proteins c-akt/metabolism

KW - DNA Primers/genetics

KW - TOR Serine-Threonine Kinases/metabolism

KW - Immediate-Early Proteins/genetics/metabolism

KW - Protein-Serine-Threonine Kinases/genetics/metabolism

KW - Forkhead Transcription Factors/antagonists & inhibitors

KW - Hibernation/physiology

KW - Muscle, Skeletal/enzymology/pathology/physiopathology

KW - Muscular Atrophy/pathology/physiopathology/prevention & control

KW - Sciuridae

KW - Starvation/enzymology/pathology

U2 - 10.1002/emmm.201201443

DO - 10.1002/emmm.201201443

M3 - SCORING: Journal article

VL - 5

SP - 80

EP - 91

JO - EMBO MOL MED

JF - EMBO MOL MED

SN - 1757-4676

IS - 1

M1 - 1

ER -