Activation of polymorphonuclear neutrophils in patients with impaired left ventricular function.
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Activation of polymorphonuclear neutrophils in patients with impaired left ventricular function. / Rudolph, Volker; Rudolph, Tanja Katharina; Hennings, J Christopher; Blankenberg, Stefan; Schnabel, Renate; Steven, Daniel; Haddad, Munif; Knittel, Katharina; Wende, Silke; Wenzel, Jürgen; Münzel, Thomas; Heitzer, Thomas; Meinertz, Thomas; Hübner, Christian; Baldus, Stephan.
In: FREE RADICAL BIO MED, Vol. 43, No. 8, 8, 2007, p. 1189-1196.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Activation of polymorphonuclear neutrophils in patients with impaired left ventricular function.
AU - Rudolph, Volker
AU - Rudolph, Tanja Katharina
AU - Hennings, J Christopher
AU - Blankenberg, Stefan
AU - Schnabel, Renate
AU - Steven, Daniel
AU - Haddad, Munif
AU - Knittel, Katharina
AU - Wende, Silke
AU - Wenzel, Jürgen
AU - Münzel, Thomas
AU - Heitzer, Thomas
AU - Meinertz, Thomas
AU - Hübner, Christian
AU - Baldus, Stephan
PY - 2007
Y1 - 2007
N2 - Activation of leukocytes and in particular polymorphonuclear neutrophils (PMN) has emerged as a critical confounder in the pathophysiology of cardiovascular disease: Myeloperoxidase (MPO), one of the principal proteins hosted in and secreted by activated PMN, has been mechanistically linked to endothelial and left ventricular (LV) dysfunction in rodent models of sepsis and ischemic cardiomyopathy. Whether PMN activation is also overt in patients with LV dysfunction of ischemic and nonischemic origin, however, remains elusive. Prospectively, 447 consecutive, stable outpatients were included in this single-center study. In 113 patients with impaired left ventricular function (ejection fraction
AB - Activation of leukocytes and in particular polymorphonuclear neutrophils (PMN) has emerged as a critical confounder in the pathophysiology of cardiovascular disease: Myeloperoxidase (MPO), one of the principal proteins hosted in and secreted by activated PMN, has been mechanistically linked to endothelial and left ventricular (LV) dysfunction in rodent models of sepsis and ischemic cardiomyopathy. Whether PMN activation is also overt in patients with LV dysfunction of ischemic and nonischemic origin, however, remains elusive. Prospectively, 447 consecutive, stable outpatients were included in this single-center study. In 113 patients with impaired left ventricular function (ejection fraction
M3 - SCORING: Zeitschriftenaufsatz
VL - 43
SP - 1189
EP - 1196
JO - FREE RADICAL BIO MED
JF - FREE RADICAL BIO MED
SN - 0891-5849
IS - 8
M1 - 8
ER -