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Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate?

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Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate? / Kölbel, Tilo; Strandberg, Karin; Donath, Tobias; Mattiasson, Ingrid; Stenflo, Johan; Lindblad, Bengt.

In: VASC ENDOVASC SURG, Vol. 42, No. 2, 2, 11.01.2008, p. 135-40.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kölbel, T, Strandberg, K, Donath, T, Mattiasson, I, Stenflo, J & Lindblad, B 2008, 'Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate?', VASC ENDOVASC SURG, vol. 42, no. 2, 2, pp. 135-40. https://doi.org/10.1177/1538574407311108

APA

Kölbel, T., Strandberg, K., Donath, T., Mattiasson, I., Stenflo, J., & Lindblad, B. (2008). Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate? VASC ENDOVASC SURG, 42(2), 135-40. [2]. https://doi.org/10.1177/1538574407311108

Vancouver

Kölbel T, Strandberg K, Donath T, Mattiasson I, Stenflo J, Lindblad B. Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate? VASC ENDOVASC SURG. 2008 Jan 11;42(2):135-40. 2. https://doi.org/10.1177/1538574407311108

Bibtex

@article{d3a7d4df2be64dcc8ccc5d118b4b9cf6,
title = "Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate?",
abstract = "Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C-protein C inhibitor (APC-PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC-PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 microg/L; 10th to 90th percentile, 0.18-1.01) compared with the control group (n = 41; median, 0.19 microg/L; 10th to 90th percentile, 0.11-0.31; P < or = .001). APC-PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r = -.19; P = .004), and age (r = .19; P = .004). APC-PCI did not correlate with AAA growth rate (r = .11; P = .14).",
keywords = "Age Factors, Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal/blood, Biomarkers/blood, Blood Coagulation, Body Mass Index, Cohort Studies, Female, Humans, Male, Middle Aged, Protein C/metabolism, Protein C Inhibitor/blood, Severity of Illness Index, Thrombin/metabolism",
author = "Tilo K{\"o}lbel and Karin Strandberg and Tobias Donath and Ingrid Mattiasson and Johan Stenflo and Bengt Lindblad",
year = "2008",
month = jan,
day = "11",
doi = "10.1177/1538574407311108",
language = "English",
volume = "42",
pages = "135--40",
journal = "VASC ENDOVASC SURG",
issn = "1538-5744",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate?

AU - Kölbel, Tilo

AU - Strandberg, Karin

AU - Donath, Tobias

AU - Mattiasson, Ingrid

AU - Stenflo, Johan

AU - Lindblad, Bengt

PY - 2008/1/11

Y1 - 2008/1/11

N2 - Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C-protein C inhibitor (APC-PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC-PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 microg/L; 10th to 90th percentile, 0.18-1.01) compared with the control group (n = 41; median, 0.19 microg/L; 10th to 90th percentile, 0.11-0.31; P < or = .001). APC-PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r = -.19; P = .004), and age (r = .19; P = .004). APC-PCI did not correlate with AAA growth rate (r = .11; P = .14).

AB - Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C-protein C inhibitor (APC-PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC-PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 microg/L; 10th to 90th percentile, 0.18-1.01) compared with the control group (n = 41; median, 0.19 microg/L; 10th to 90th percentile, 0.11-0.31; P < or = .001). APC-PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r = -.19; P = .004), and age (r = .19; P = .004). APC-PCI did not correlate with AAA growth rate (r = .11; P = .14).

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Aortic Aneurysm, Abdominal/blood

KW - Biomarkers/blood

KW - Blood Coagulation

KW - Body Mass Index

KW - Cohort Studies

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Protein C/metabolism

KW - Protein C Inhibitor/blood

KW - Severity of Illness Index

KW - Thrombin/metabolism

UR - http://www.ncbi.nlm.nih.gov/pubmed/18184931?dopt=Citation

U2 - 10.1177/1538574407311108

DO - 10.1177/1538574407311108

M3 - SCORING: Journal article

C2 - 18184931

VL - 42

SP - 135

EP - 140

JO - VASC ENDOVASC SURG

JF - VASC ENDOVASC SURG

SN - 1538-5744

IS - 2

M1 - 2

ER -