Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate?
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Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate? / Kölbel, Tilo; Strandberg, Karin; Donath, Tobias; Mattiasson, Ingrid; Stenflo, Johan; Lindblad, Bengt.
in: VASC ENDOVASC SURG, Jahrgang 42, Nr. 2, 2, 11.01.2008, S. 135-40.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate?
AU - Kölbel, Tilo
AU - Strandberg, Karin
AU - Donath, Tobias
AU - Mattiasson, Ingrid
AU - Stenflo, Johan
AU - Lindblad, Bengt
PY - 2008/1/11
Y1 - 2008/1/11
N2 - Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C-protein C inhibitor (APC-PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC-PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 microg/L; 10th to 90th percentile, 0.18-1.01) compared with the control group (n = 41; median, 0.19 microg/L; 10th to 90th percentile, 0.11-0.31; P < or = .001). APC-PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r = -.19; P = .004), and age (r = .19; P = .004). APC-PCI did not correlate with AAA growth rate (r = .11; P = .14).
AB - Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C-protein C inhibitor (APC-PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC-PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 microg/L; 10th to 90th percentile, 0.18-1.01) compared with the control group (n = 41; median, 0.19 microg/L; 10th to 90th percentile, 0.11-0.31; P < or = .001). APC-PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r = -.19; P = .004), and age (r = .19; P = .004). APC-PCI did not correlate with AAA growth rate (r = .11; P = .14).
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Aortic Aneurysm, Abdominal/blood
KW - Biomarkers/blood
KW - Blood Coagulation
KW - Body Mass Index
KW - Cohort Studies
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Protein C/metabolism
KW - Protein C Inhibitor/blood
KW - Severity of Illness Index
KW - Thrombin/metabolism
UR - http://www.ncbi.nlm.nih.gov/pubmed/18184931?dopt=Citation
U2 - 10.1177/1538574407311108
DO - 10.1177/1538574407311108
M3 - SCORING: Journal article
C2 - 18184931
VL - 42
SP - 135
EP - 140
JO - VASC ENDOVASC SURG
JF - VASC ENDOVASC SURG
SN - 1538-5744
IS - 2
M1 - 2
ER -