Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients
Standard
Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients. / Tachezy, Michael; Zander, Hilke; Gebauer, Florian; Marx, Andreas; Kaifi, Jussuf T; Izbicki, Jakob R; Bockhorn, Maximilian.
In: J SURG RES, Vol. 177, No. 1, 01.09.2012, p. e15-20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients
AU - Tachezy, Michael
AU - Zander, Hilke
AU - Gebauer, Florian
AU - Marx, Andreas
AU - Kaifi, Jussuf T
AU - Izbicki, Jakob R
AU - Bockhorn, Maximilian
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2012/9/1
Y1 - 2012/9/1
N2 - BACKGROUND: The activated leukocyte cell adhesion molecule (ALCAM, CD166) has been reported to be involved in tumorigenesis of colorectal cancer (CRC) and to function as a cancer stem cell marker. Controversial data exist regarding the prognostic power of ALCAM expression in CRC. Here, we evaluate the expression of ALCAM in a cohort of CRC patients and its usage as a prognostic marker for survival.MATERIALS AND METHODS: Tissue specimens from 299 patients with CRC treated between 1993 and 2006 were analyzed via ALCAM immunohistochemistry (clone MOG/07) using a tissue microarray. Results were correlated with clinical, histopathological, and patient survival data (Chi-square test, Kaplan-Meier analysis, and log-rank test, respectively). Multivariate analysis also was performed (Cox regression).RESULTS: ALCAM is expressed in most primary (76%) and secondary (62%) CRC lesions (P = 0.014). Immunohistochemistry revealed an inverse association with tumor grading (P = 0.002) but not with any other clinical or histopathological data. Kaplan-Meier survival analysis revealed a significant overall survival benefit in the group of ALCAM-positive patients (P = 0.019). Multivariate analysis showed that ALCAM is an independent positive prognostic marker for overall survival (P = 0.023).CONCLUSIONS: ALCAM expression is a positive prognostic marker for overall survival of CRC patients, and its detection might help to optimize the existing prognostic staging system. Elevated expression in higher differentiated tumors might indicate a potential role in the early steps of tumorigenesis, and its loss might be associated with reduced cellular adhesion, resulting in a higher metastatic potential of the tumor. Further studies must be conducted investigating these hypotheses.
AB - BACKGROUND: The activated leukocyte cell adhesion molecule (ALCAM, CD166) has been reported to be involved in tumorigenesis of colorectal cancer (CRC) and to function as a cancer stem cell marker. Controversial data exist regarding the prognostic power of ALCAM expression in CRC. Here, we evaluate the expression of ALCAM in a cohort of CRC patients and its usage as a prognostic marker for survival.MATERIALS AND METHODS: Tissue specimens from 299 patients with CRC treated between 1993 and 2006 were analyzed via ALCAM immunohistochemistry (clone MOG/07) using a tissue microarray. Results were correlated with clinical, histopathological, and patient survival data (Chi-square test, Kaplan-Meier analysis, and log-rank test, respectively). Multivariate analysis also was performed (Cox regression).RESULTS: ALCAM is expressed in most primary (76%) and secondary (62%) CRC lesions (P = 0.014). Immunohistochemistry revealed an inverse association with tumor grading (P = 0.002) but not with any other clinical or histopathological data. Kaplan-Meier survival analysis revealed a significant overall survival benefit in the group of ALCAM-positive patients (P = 0.019). Multivariate analysis showed that ALCAM is an independent positive prognostic marker for overall survival (P = 0.023).CONCLUSIONS: ALCAM expression is a positive prognostic marker for overall survival of CRC patients, and its detection might help to optimize the existing prognostic staging system. Elevated expression in higher differentiated tumors might indicate a potential role in the early steps of tumorigenesis, and its loss might be associated with reduced cellular adhesion, resulting in a higher metastatic potential of the tumor. Further studies must be conducted investigating these hypotheses.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Antigens, CD
KW - Cell Adhesion Molecules, Neuronal
KW - Colon
KW - Colorectal Neoplasms
KW - Female
KW - Fetal Proteins
KW - Humans
KW - Kaplan-Meier Estimate
KW - Liver
KW - Liver Neoplasms
KW - Lymph Nodes
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Neoplasm Metastasis
KW - Prognosis
KW - Tumor Markers, Biological
KW - Young Adult
U2 - 10.1016/j.jss.2012.02.013
DO - 10.1016/j.jss.2012.02.013
M3 - SCORING: Journal article
C2 - 22482754
VL - 177
SP - e15-20
JO - J SURG RES
JF - J SURG RES
SN - 0022-4804
IS - 1
ER -