Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients

TY - JOUR

T1 - Activated leukocyte cell adhesion molecule (CD166)--its prognostic power for colorectal cancer patients

AU - Tachezy, Michael

AU - Zander, Hilke

AU - Gebauer, Florian

AU - Marx, Andreas

AU - Kaifi, Jussuf T

AU - Izbicki, Jakob R

AU - Bockhorn, Maximilian

N1 - Copyright © 2012 Elsevier Inc. All rights reserved.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - BACKGROUND: The activated leukocyte cell adhesion molecule (ALCAM, CD166) has been reported to be involved in tumorigenesis of colorectal cancer (CRC) and to function as a cancer stem cell marker. Controversial data exist regarding the prognostic power of ALCAM expression in CRC. Here, we evaluate the expression of ALCAM in a cohort of CRC patients and its usage as a prognostic marker for survival.MATERIALS AND METHODS: Tissue specimens from 299 patients with CRC treated between 1993 and 2006 were analyzed via ALCAM immunohistochemistry (clone MOG/07) using a tissue microarray. Results were correlated with clinical, histopathological, and patient survival data (Chi-square test, Kaplan-Meier analysis, and log-rank test, respectively). Multivariate analysis also was performed (Cox regression).RESULTS: ALCAM is expressed in most primary (76%) and secondary (62%) CRC lesions (P = 0.014). Immunohistochemistry revealed an inverse association with tumor grading (P = 0.002) but not with any other clinical or histopathological data. Kaplan-Meier survival analysis revealed a significant overall survival benefit in the group of ALCAM-positive patients (P = 0.019). Multivariate analysis showed that ALCAM is an independent positive prognostic marker for overall survival (P = 0.023).CONCLUSIONS: ALCAM expression is a positive prognostic marker for overall survival of CRC patients, and its detection might help to optimize the existing prognostic staging system. Elevated expression in higher differentiated tumors might indicate a potential role in the early steps of tumorigenesis, and its loss might be associated with reduced cellular adhesion, resulting in a higher metastatic potential of the tumor. Further studies must be conducted investigating these hypotheses.

AB - BACKGROUND: The activated leukocyte cell adhesion molecule (ALCAM, CD166) has been reported to be involved in tumorigenesis of colorectal cancer (CRC) and to function as a cancer stem cell marker. Controversial data exist regarding the prognostic power of ALCAM expression in CRC. Here, we evaluate the expression of ALCAM in a cohort of CRC patients and its usage as a prognostic marker for survival.MATERIALS AND METHODS: Tissue specimens from 299 patients with CRC treated between 1993 and 2006 were analyzed via ALCAM immunohistochemistry (clone MOG/07) using a tissue microarray. Results were correlated with clinical, histopathological, and patient survival data (Chi-square test, Kaplan-Meier analysis, and log-rank test, respectively). Multivariate analysis also was performed (Cox regression).RESULTS: ALCAM is expressed in most primary (76%) and secondary (62%) CRC lesions (P = 0.014). Immunohistochemistry revealed an inverse association with tumor grading (P = 0.002) but not with any other clinical or histopathological data. Kaplan-Meier survival analysis revealed a significant overall survival benefit in the group of ALCAM-positive patients (P = 0.019). Multivariate analysis showed that ALCAM is an independent positive prognostic marker for overall survival (P = 0.023).CONCLUSIONS: ALCAM expression is a positive prognostic marker for overall survival of CRC patients, and its detection might help to optimize the existing prognostic staging system. Elevated expression in higher differentiated tumors might indicate a potential role in the early steps of tumorigenesis, and its loss might be associated with reduced cellular adhesion, resulting in a higher metastatic potential of the tumor. Further studies must be conducted investigating these hypotheses.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD

KW - Cell Adhesion Molecules, Neuronal

KW - Colon

KW - Colorectal Neoplasms

KW - Female

KW - Fetal Proteins

KW - Humans

KW - Kaplan-Meier Estimate

KW - Liver

KW - Liver Neoplasms

KW - Lymph Nodes

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoplasm Metastasis

KW - Prognosis

KW - Tumor Markers, Biological

KW - Young Adult

U2 - 10.1016/j.jss.2012.02.013

DO - 10.1016/j.jss.2012.02.013

M3 - SCORING: Journal article

C2 - 22482754

VL - 177

SP - e15-20

JO - J SURG RES

JF - J SURG RES

SN - 0022-4804

IS - 1

ER -