Actin-Dependent Regulation of Borrelia burgdorferi Phagocytosis by Macrophages
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Actin-Dependent Regulation of Borrelia burgdorferi Phagocytosis by Macrophages. / Naj, Xenia; Linder, Stefan.
In: CURR TOP MICROBIOL, Vol. 399, 2017, p. 133-154.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Actin-Dependent Regulation of Borrelia burgdorferi Phagocytosis by Macrophages
AU - Naj, Xenia
AU - Linder, Stefan
PY - 2017
Y1 - 2017
N2 - The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting primarily skin, nervous system, and joints. If an infection with Borrelia proceeds unchecked, the disease can also enter a chronic stage, leading to the development of neuroborreliosis or cardiac arrhythmia. Successful elimination of B. burgdorferi by the host immune system is thus decisive for the positive outcome of a respective infection. Accordingly, host immune cells such as macrophages and dendritic cells have to be able to efficiently internalize and degrade infecting spirochetes. These processes are based on closely controlled rearrangements of the actin cytoskeleton, which enables the spatiotemporally fine-tuned formation of cellular protrusions and compartments that assist in the capturing, immobilization, and uptake of borreliae, as well as their further intracellular processing. Here, we discuss actin-based structures, in particular filopodia and coiling pseudopods that are involved in phagocytosis of B. burgdorferi by macrophages, their regulation by actin-associated proteins such as formins and Arp2/3 complex, as well as the subsequent intracellular processing of borreliae.
AB - The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting primarily skin, nervous system, and joints. If an infection with Borrelia proceeds unchecked, the disease can also enter a chronic stage, leading to the development of neuroborreliosis or cardiac arrhythmia. Successful elimination of B. burgdorferi by the host immune system is thus decisive for the positive outcome of a respective infection. Accordingly, host immune cells such as macrophages and dendritic cells have to be able to efficiently internalize and degrade infecting spirochetes. These processes are based on closely controlled rearrangements of the actin cytoskeleton, which enables the spatiotemporally fine-tuned formation of cellular protrusions and compartments that assist in the capturing, immobilization, and uptake of borreliae, as well as their further intracellular processing. Here, we discuss actin-based structures, in particular filopodia and coiling pseudopods that are involved in phagocytosis of B. burgdorferi by macrophages, their regulation by actin-associated proteins such as formins and Arp2/3 complex, as well as the subsequent intracellular processing of borreliae.
U2 - 10.1007/82_2016_26
DO - 10.1007/82_2016_26
M3 - SCORING: Review article
C2 - 27744511
VL - 399
SP - 133
EP - 154
JO - CURR TOP MICROBIOL
JF - CURR TOP MICROBIOL
SN - 0070-217X
ER -