Actin assembly mechanisms at a glance
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Actin assembly mechanisms at a glance. / Rottner, Klemens; Faix, Jan; Bogdan, Sven; Linder, Stefan; Kerkhoff, Eugen.
In: J CELL SCI, Vol. 130, No. 20, 15.10.2017, p. 3427-3435.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Actin assembly mechanisms at a glance
AU - Rottner, Klemens
AU - Faix, Jan
AU - Bogdan, Sven
AU - Linder, Stefan
AU - Kerkhoff, Eugen
N1 - © 2017. Published by The Company of Biologists Ltd.
PY - 2017/10/15
Y1 - 2017/10/15
N2 - The actin cytoskeleton and associated motor proteins provide the driving forces for establishing the astonishing morphological diversity and dynamics of mammalian cells. Aside from functions in protruding and contracting cell membranes for motility, differentiation or cell division, the actin cytoskeleton provides forces to shape and move intracellular membranes of organelles and vesicles. To establish the many different actin assembly functions required in time and space, actin nucleators are targeted to specific subcellular compartments, thereby restricting the generation of specific actin filament structures to those sites. Recent research has revealed that targeting and activation of actin filament nucleators, elongators and myosin motors are tightly coordinated by conserved protein complexes to orchestrate force generation. In this Cell Science at a Glance article and the accompanying poster, we summarize and discuss the current knowledge on the corresponding protein complexes and their modes of action in actin nucleation, elongation and force generation.
AB - The actin cytoskeleton and associated motor proteins provide the driving forces for establishing the astonishing morphological diversity and dynamics of mammalian cells. Aside from functions in protruding and contracting cell membranes for motility, differentiation or cell division, the actin cytoskeleton provides forces to shape and move intracellular membranes of organelles and vesicles. To establish the many different actin assembly functions required in time and space, actin nucleators are targeted to specific subcellular compartments, thereby restricting the generation of specific actin filament structures to those sites. Recent research has revealed that targeting and activation of actin filament nucleators, elongators and myosin motors are tightly coordinated by conserved protein complexes to orchestrate force generation. In this Cell Science at a Glance article and the accompanying poster, we summarize and discuss the current knowledge on the corresponding protein complexes and their modes of action in actin nucleation, elongation and force generation.
KW - Journal Article
KW - Review
U2 - 10.1242/jcs.206433
DO - 10.1242/jcs.206433
M3 - SCORING: Review article
C2 - 29032357
VL - 130
SP - 3427
EP - 3435
JO - J CELL SCI
JF - J CELL SCI
SN - 0021-9533
IS - 20
ER -