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Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma

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Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma. / Bockhorn, M; Frilling, A; Kalinin, V; Schröder, S; Broelsch, C E.

In: EXP CLIN ENDOCR DIAB, Vol. 108, No. 1, 01.01.2000, p. 49-53.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bockhorn, M, Frilling, A, Kalinin, V, Schröder, S & Broelsch, CE 2000, 'Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma', EXP CLIN ENDOCR DIAB, vol. 108, no. 1, pp. 49-53.

APA

Bockhorn, M., Frilling, A., Kalinin, V., Schröder, S., & Broelsch, C. E. (2000). Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma. EXP CLIN ENDOCR DIAB, 108(1), 49-53.

Vancouver

Bockhorn M, Frilling A, Kalinin V, Schröder S, Broelsch CE. Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma. EXP CLIN ENDOCR DIAB. 2000 Jan 1;108(1):49-53.

Bibtex

@article{c575734cacc94330bbcd35748785d55b,
title = "Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma",
abstract = "Medullary thyroid carcinoma (MTC) occurs sporadically (sMTC) or as part of the inherited cancer syndrome, multiple endocrine neoplasia type 2 (MEN 2). While the occurence of the MEN 2 syndrome is associated with mutations in the RET protooncogene, the reason for carcinogenesis in sMTC still remains unclear. Ras is a frequently mutated oncogene in a broad spectrum of human tumors and has been found in about 50% of follicular, papillary or anaplastic thyroid carcinomas. The purpose of this study was to determine, whether mutations in the ras oncogene could play a possible role in the carcinogenesis of sMTC. In this study we analyzed 15 sMTC for mutations in the hotspots codon 12, 13 and 61 of the H- and K-ras oncogene. We used the direct sequencing technique. In none of the examined tumors we were able to detect a mutation in the codon 12, 13 and 61 of the H-ras and K-ras oncogene. Based upon these results, we conclude that H- and K-ras do not play an important role in the carcinogenesis of sMTC.",
keywords = "Base Sequence, Carcinoma, Medullary, Codon, Genes, ras, Humans, Mutation, Polymerase Chain Reaction, Proto-Oncogene Proteins p21(ras), Thyroid Neoplasms",
author = "M Bockhorn and A Frilling and V Kalinin and S Schr{\"o}der and Broelsch, {C E}",
year = "2000",
month = jan,
day = "1",
language = "English",
volume = "108",
pages = "49--53",
journal = "EXP CLIN ENDOCR DIAB",
issn = "0947-7349",
publisher = "Georg Thieme Verlag KG",
number = "1",

}

RIS

TY - JOUR

T1 - Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma

AU - Bockhorn, M

AU - Frilling, A

AU - Kalinin, V

AU - Schröder, S

AU - Broelsch, C E

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Medullary thyroid carcinoma (MTC) occurs sporadically (sMTC) or as part of the inherited cancer syndrome, multiple endocrine neoplasia type 2 (MEN 2). While the occurence of the MEN 2 syndrome is associated with mutations in the RET protooncogene, the reason for carcinogenesis in sMTC still remains unclear. Ras is a frequently mutated oncogene in a broad spectrum of human tumors and has been found in about 50% of follicular, papillary or anaplastic thyroid carcinomas. The purpose of this study was to determine, whether mutations in the ras oncogene could play a possible role in the carcinogenesis of sMTC. In this study we analyzed 15 sMTC for mutations in the hotspots codon 12, 13 and 61 of the H- and K-ras oncogene. We used the direct sequencing technique. In none of the examined tumors we were able to detect a mutation in the codon 12, 13 and 61 of the H-ras and K-ras oncogene. Based upon these results, we conclude that H- and K-ras do not play an important role in the carcinogenesis of sMTC.

AB - Medullary thyroid carcinoma (MTC) occurs sporadically (sMTC) or as part of the inherited cancer syndrome, multiple endocrine neoplasia type 2 (MEN 2). While the occurence of the MEN 2 syndrome is associated with mutations in the RET protooncogene, the reason for carcinogenesis in sMTC still remains unclear. Ras is a frequently mutated oncogene in a broad spectrum of human tumors and has been found in about 50% of follicular, papillary or anaplastic thyroid carcinomas. The purpose of this study was to determine, whether mutations in the ras oncogene could play a possible role in the carcinogenesis of sMTC. In this study we analyzed 15 sMTC for mutations in the hotspots codon 12, 13 and 61 of the H- and K-ras oncogene. We used the direct sequencing technique. In none of the examined tumors we were able to detect a mutation in the codon 12, 13 and 61 of the H-ras and K-ras oncogene. Based upon these results, we conclude that H- and K-ras do not play an important role in the carcinogenesis of sMTC.

KW - Base Sequence

KW - Carcinoma, Medullary

KW - Codon

KW - Genes, ras

KW - Humans

KW - Mutation

KW - Polymerase Chain Reaction

KW - Proto-Oncogene Proteins p21(ras)

KW - Thyroid Neoplasms

M3 - SCORING: Journal article

C2 - 10768832

VL - 108

SP - 49

EP - 53

JO - EXP CLIN ENDOCR DIAB

JF - EXP CLIN ENDOCR DIAB

SN - 0947-7349

IS - 1

ER -