Abnormal interhemispheric inhibition in musician's dystonia - Trait or state?
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Abnormal interhemispheric inhibition in musician's dystonia - Trait or state? / Bäumer, Tobias; Schmidt, Alexander; Heldmann, Marcus; Landwehr , Moritz ; Simmer, Anna; Tönniges, Diana ; Münte, Thomas; Lohmann, Katja; Altenmüller, Eckart; Klein, Christine; Münchau, Alexander.
In: PARKINSONISM RELAT D, Vol. 25, 04.2016, p. 33-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Abnormal interhemispheric inhibition in musician's dystonia - Trait or state?
AU - Bäumer, Tobias
AU - Schmidt, Alexander
AU - Heldmann, Marcus
AU - Landwehr , Moritz
AU - Simmer, Anna
AU - Tönniges, Diana
AU - Münte, Thomas
AU - Lohmann, Katja
AU - Altenmüller, Eckart
AU - Klein, Christine
AU - Münchau, Alexander
N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.
PY - 2016/4
Y1 - 2016/4
N2 - INTRODUCTION: A clustering of relatives with dystonia has been reported in families with musician's dystonia suggesting a genetic contribution to this disease. The aim of the present study was to determine whether interhemispheric inhibition (IHI) measured with transcranial magnetic stimulation is impaired in healthy family members rendering it a suitable endophenotypic marker for musician's dystonia.METHODS: Patients with musician's hand dystonia (n = 21), patients with sporadic writer's cramp (n = 15), their healthy family members (n = 27), healthy musicians (n = 12) and healthy non-musicians (n = 12) were included. An extended interview about the family history and musical activity was performed. IHI in both hemispheres was measured using transcranial magnetic stimulation.RESULTS: A stepwise regression analysis revealed musical activity (p = 0.001) and a family history of dystonia (p = 0.008) but not dystonia per se, age, handedness or gender as relevant factors modulating IHI.CONCLUSION: These data support the notion of a genetic background of musician's hand dystonia and suggests that reduced IHI is a possible endophenotypic marker of this disorder.
AB - INTRODUCTION: A clustering of relatives with dystonia has been reported in families with musician's dystonia suggesting a genetic contribution to this disease. The aim of the present study was to determine whether interhemispheric inhibition (IHI) measured with transcranial magnetic stimulation is impaired in healthy family members rendering it a suitable endophenotypic marker for musician's dystonia.METHODS: Patients with musician's hand dystonia (n = 21), patients with sporadic writer's cramp (n = 15), their healthy family members (n = 27), healthy musicians (n = 12) and healthy non-musicians (n = 12) were included. An extended interview about the family history and musical activity was performed. IHI in both hemispheres was measured using transcranial magnetic stimulation.RESULTS: A stepwise regression analysis revealed musical activity (p = 0.001) and a family history of dystonia (p = 0.008) but not dystonia per se, age, handedness or gender as relevant factors modulating IHI.CONCLUSION: These data support the notion of a genetic background of musician's hand dystonia and suggests that reduced IHI is a possible endophenotypic marker of this disorder.
KW - Journal Article
KW - Research Support, N.I.H., Extramural
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.parkreldis.2016.02.018
DO - 10.1016/j.parkreldis.2016.02.018
M3 - SCORING: Journal article
C2 - 26923523
VL - 25
SP - 33
EP - 38
JO - PARKINSONISM RELAT D
JF - PARKINSONISM RELAT D
SN - 1353-8020
ER -