Abnormal interhemispheric inhibition in musician's dystonia - Trait or state?

Standard

Abnormal interhemispheric inhibition in musician's dystonia - Trait or state? / Bäumer, Tobias; Schmidt, Alexander; Heldmann, Marcus; Landwehr , Moritz ; Simmer, Anna; Tönniges, Diana ; Münte, Thomas; Lohmann, Katja; Altenmüller, Eckart; Klein, Christine; Münchau, Alexander.

in: PARKINSONISM RELAT D, Jahrgang 25, 04.2016, S. 33-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

Harvard

Bäumer, T, Schmidt, A, Heldmann, M, Landwehr , M, Simmer, A, Tönniges, D, Münte, T, Lohmann, K, Altenmüller, E, Klein, C & Münchau, A 2016, 'Abnormal interhemispheric inhibition in musician's dystonia - Trait or state?', PARKINSONISM RELAT D, Jg. 25, S. 33-8. https://doi.org/10.1016/j.parkreldis.2016.02.018

APA

Bäumer, T., Schmidt, A., Heldmann, M., Landwehr , M., Simmer, A., Tönniges, D., Münte, T., Lohmann, K., Altenmüller, E., Klein, C., & Münchau, A. (2016). Abnormal interhemispheric inhibition in musician's dystonia - Trait or state? PARKINSONISM RELAT D, 25, 33-8. https://doi.org/10.1016/j.parkreldis.2016.02.018

Vancouver

Bibtex

@article{1b1647a310044f76918be8bf4da9a248,
title = "Abnormal interhemispheric inhibition in musician's dystonia - Trait or state?",
abstract = "INTRODUCTION: A clustering of relatives with dystonia has been reported in families with musician's dystonia suggesting a genetic contribution to this disease. The aim of the present study was to determine whether interhemispheric inhibition (IHI) measured with transcranial magnetic stimulation is impaired in healthy family members rendering it a suitable endophenotypic marker for musician's dystonia.METHODS: Patients with musician's hand dystonia (n = 21), patients with sporadic writer's cramp (n = 15), their healthy family members (n = 27), healthy musicians (n = 12) and healthy non-musicians (n = 12) were included. An extended interview about the family history and musical activity was performed. IHI in both hemispheres was measured using transcranial magnetic stimulation.RESULTS: A stepwise regression analysis revealed musical activity (p = 0.001) and a family history of dystonia (p = 0.008) but not dystonia per se, age, handedness or gender as relevant factors modulating IHI.CONCLUSION: These data support the notion of a genetic background of musician's hand dystonia and suggests that reduced IHI is a possible endophenotypic marker of this disorder.",
keywords = "Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Tobias B{\"a}umer and Alexander Schmidt and Marcus Heldmann and Moritz Landwehr and Anna Simmer and Diana T{\"o}nniges and Thomas M{\"u}nte and Katja Lohmann and Eckart Altenm{\"u}ller and Christine Klein and Alexander M{\"u}nchau",
note = "Copyright {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
month = apr,
doi = "10.1016/j.parkreldis.2016.02.018",
language = "English",
volume = "25",
pages = "33--8",
journal = "PARKINSONISM RELAT D",
issn = "1353-8020",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Abnormal interhemispheric inhibition in musician's dystonia - Trait or state?

AU - Bäumer, Tobias

AU - Schmidt, Alexander

AU - Heldmann, Marcus

AU - Landwehr , Moritz

AU - Simmer, Anna

AU - Tönniges, Diana

AU - Münte, Thomas

AU - Lohmann, Katja

AU - Altenmüller, Eckart

AU - Klein, Christine

AU - Münchau, Alexander

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/4

Y1 - 2016/4

N2 - INTRODUCTION: A clustering of relatives with dystonia has been reported in families with musician's dystonia suggesting a genetic contribution to this disease. The aim of the present study was to determine whether interhemispheric inhibition (IHI) measured with transcranial magnetic stimulation is impaired in healthy family members rendering it a suitable endophenotypic marker for musician's dystonia.METHODS: Patients with musician's hand dystonia (n = 21), patients with sporadic writer's cramp (n = 15), their healthy family members (n = 27), healthy musicians (n = 12) and healthy non-musicians (n = 12) were included. An extended interview about the family history and musical activity was performed. IHI in both hemispheres was measured using transcranial magnetic stimulation.RESULTS: A stepwise regression analysis revealed musical activity (p = 0.001) and a family history of dystonia (p = 0.008) but not dystonia per se, age, handedness or gender as relevant factors modulating IHI.CONCLUSION: These data support the notion of a genetic background of musician's hand dystonia and suggests that reduced IHI is a possible endophenotypic marker of this disorder.

AB - INTRODUCTION: A clustering of relatives with dystonia has been reported in families with musician's dystonia suggesting a genetic contribution to this disease. The aim of the present study was to determine whether interhemispheric inhibition (IHI) measured with transcranial magnetic stimulation is impaired in healthy family members rendering it a suitable endophenotypic marker for musician's dystonia.METHODS: Patients with musician's hand dystonia (n = 21), patients with sporadic writer's cramp (n = 15), their healthy family members (n = 27), healthy musicians (n = 12) and healthy non-musicians (n = 12) were included. An extended interview about the family history and musical activity was performed. IHI in both hemispheres was measured using transcranial magnetic stimulation.RESULTS: A stepwise regression analysis revealed musical activity (p = 0.001) and a family history of dystonia (p = 0.008) but not dystonia per se, age, handedness or gender as relevant factors modulating IHI.CONCLUSION: These data support the notion of a genetic background of musician's hand dystonia and suggests that reduced IHI is a possible endophenotypic marker of this disorder.

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.parkreldis.2016.02.018

DO - 10.1016/j.parkreldis.2016.02.018

M3 - SCORING: Journal article

C2 - 26923523

VL - 25

SP - 33

EP - 38

JO - PARKINSONISM RELAT D

JF - PARKINSONISM RELAT D

SN - 1353-8020

ER -