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A vasopressor factor partially purified from human parathyroid glands

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A vasopressor factor partially purified from human parathyroid glands. / Schlüter, H; Quante, C; Buchholz, B; Dietl, K H; Spieker, C; Karas, M; Zidek, W.

In: BIOCHEM BIOPH RES CO, Vol. 188, No. 1, 15.10.1992, p. 323-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schlüter, H, Quante, C, Buchholz, B, Dietl, KH, Spieker, C, Karas, M & Zidek, W 1992, 'A vasopressor factor partially purified from human parathyroid glands', BIOCHEM BIOPH RES CO, vol. 188, no. 1, pp. 323-9.

APA

Schlüter, H., Quante, C., Buchholz, B., Dietl, K. H., Spieker, C., Karas, M., & Zidek, W. (1992). A vasopressor factor partially purified from human parathyroid glands. BIOCHEM BIOPH RES CO, 188(1), 323-9.

Vancouver

Schlüter H, Quante C, Buchholz B, Dietl KH, Spieker C, Karas M et al. A vasopressor factor partially purified from human parathyroid glands. BIOCHEM BIOPH RES CO. 1992 Oct 15;188(1):323-9.

Bibtex

@article{c9b2520dc20c4e6b80203886ada87163,
title = "A vasopressor factor partially purified from human parathyroid glands",
abstract = "Recently, a parathyroid hypertensive factor was postulated to play a role in the pathogenesis of hypertension in genetically hypertensive rats. Therefore it was examined, whether in human parathyroid glands a vasopressor substance can be detected. For this purpose, homogenates of hyperplastic parathyroid glands from 20 patients with tertiary hyperparathyroidism were deproteinized and fractionated by gel chromatography. The fractions obtained were tested for vasopressor activity in isolated perfused rat kidneys. A vasopressor fraction containing substances of 0.6-2.5 kDa was identified in the parathyroid glands. The responsible product was heat sensitive, peptidase-, trypsin- and carboxypeptidase y- sensitive and hydrophilic, as it did not bind to hydrophobic reversed-phase gel. These results suggest that parathyroid glands contain a hydrophilic peptide-like vasopressor substance different from the parathyroid hormone.",
keywords = "Angiotensin II, Animals, Endopeptidases, Humans, Hyperparathyroidism, Hypertension, In Vitro Techniques, Kidney, Kidney Failure, Chronic, Male, Mass Spectrometry, Muscle, Smooth, Vascular, Parathyroid Glands, Rats, Rats, Inbred WKY, Renal Artery, Renal Circulation, Tissue Extracts, Vasoconstrictor Agents, Journal Article, Research Support, Non-U.S. Gov't",
author = "H Schl{\"u}ter and C Quante and B Buchholz and Dietl, {K H} and C Spieker and M Karas and W Zidek",
year = "1992",
month = oct,
day = "15",
language = "English",
volume = "188",
pages = "323--9",
journal = "BIOCHEM BIOPH RES CO",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - A vasopressor factor partially purified from human parathyroid glands

AU - Schlüter, H

AU - Quante, C

AU - Buchholz, B

AU - Dietl, K H

AU - Spieker, C

AU - Karas, M

AU - Zidek, W

PY - 1992/10/15

Y1 - 1992/10/15

N2 - Recently, a parathyroid hypertensive factor was postulated to play a role in the pathogenesis of hypertension in genetically hypertensive rats. Therefore it was examined, whether in human parathyroid glands a vasopressor substance can be detected. For this purpose, homogenates of hyperplastic parathyroid glands from 20 patients with tertiary hyperparathyroidism were deproteinized and fractionated by gel chromatography. The fractions obtained were tested for vasopressor activity in isolated perfused rat kidneys. A vasopressor fraction containing substances of 0.6-2.5 kDa was identified in the parathyroid glands. The responsible product was heat sensitive, peptidase-, trypsin- and carboxypeptidase y- sensitive and hydrophilic, as it did not bind to hydrophobic reversed-phase gel. These results suggest that parathyroid glands contain a hydrophilic peptide-like vasopressor substance different from the parathyroid hormone.

AB - Recently, a parathyroid hypertensive factor was postulated to play a role in the pathogenesis of hypertension in genetically hypertensive rats. Therefore it was examined, whether in human parathyroid glands a vasopressor substance can be detected. For this purpose, homogenates of hyperplastic parathyroid glands from 20 patients with tertiary hyperparathyroidism were deproteinized and fractionated by gel chromatography. The fractions obtained were tested for vasopressor activity in isolated perfused rat kidneys. A vasopressor fraction containing substances of 0.6-2.5 kDa was identified in the parathyroid glands. The responsible product was heat sensitive, peptidase-, trypsin- and carboxypeptidase y- sensitive and hydrophilic, as it did not bind to hydrophobic reversed-phase gel. These results suggest that parathyroid glands contain a hydrophilic peptide-like vasopressor substance different from the parathyroid hormone.

KW - Angiotensin II

KW - Animals

KW - Endopeptidases

KW - Humans

KW - Hyperparathyroidism

KW - Hypertension

KW - In Vitro Techniques

KW - Kidney

KW - Kidney Failure, Chronic

KW - Male

KW - Mass Spectrometry

KW - Muscle, Smooth, Vascular

KW - Parathyroid Glands

KW - Rats

KW - Rats, Inbred WKY

KW - Renal Artery

KW - Renal Circulation

KW - Tissue Extracts

KW - Vasoconstrictor Agents

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 1417852

VL - 188

SP - 323

EP - 329

JO - BIOCHEM BIOPH RES CO

JF - BIOCHEM BIOPH RES CO

SN - 0006-291X

IS - 1

ER -