A track of the clones: new developments in cellular barcoding
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A track of the clones: new developments in cellular barcoding. / Lyne, Anne-Marie; Kent, David G; Laurenti, Elisa; Cornils, Kerstin; Glauche, Ingmar; Perié, Leïla.
In: EXP HEMATOL, Vol. 68, 12.2018, p. 15-20.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - A track of the clones: new developments in cellular barcoding
AU - Lyne, Anne-Marie
AU - Kent, David G
AU - Laurenti, Elisa
AU - Cornils, Kerstin
AU - Glauche, Ingmar
AU - Perié, Leïla
N1 - Copyright © 2018. Published by Elsevier Inc.
PY - 2018/12
Y1 - 2018/12
N2 - International experts from multiple disciplines gathered at Homerton College in Cambridge, UK from September 12-14, 2018 to consider recent advances and emerging opportunities in the clonal tracking of hematopoiesis in one of a series of StemCellMathLab workshops. The group included 35 participants with experience in the fields of theoretical and experimental aspects of clonal tracking, and ranged from doctoral students to senior professors. Data from a variety of model systems and from clinical gene therapy trials were discussed, along with strategies for data analysis and sharing and challenges arising due to underlying assumptions in data interpretation and communication. Recognizing the power of this technology underpinned a group consensus of a need for improved mechanisms for sharing data and analytical protocols to maintain reproducibility and rigor in its application to complex tissues.
AB - International experts from multiple disciplines gathered at Homerton College in Cambridge, UK from September 12-14, 2018 to consider recent advances and emerging opportunities in the clonal tracking of hematopoiesis in one of a series of StemCellMathLab workshops. The group included 35 participants with experience in the fields of theoretical and experimental aspects of clonal tracking, and ranged from doctoral students to senior professors. Data from a variety of model systems and from clinical gene therapy trials were discussed, along with strategies for data analysis and sharing and challenges arising due to underlying assumptions in data interpretation and communication. Recognizing the power of this technology underpinned a group consensus of a need for improved mechanisms for sharing data and analytical protocols to maintain reproducibility and rigor in its application to complex tissues.
KW - Journal Article
KW - Review
KW - Genetic Therapy
KW - DNA Barcoding, Taxonomic/methods
KW - Guidelines as Topic
KW - Reproducibility of Results
KW - Clinical Trials as Topic
KW - Data Display/standards
KW - Genetic Markers
KW - Forecasting
KW - DNA Transposable Elements
KW - Virus Integration/genetics
KW - Cell Lineage
KW - Clone Cells/cytology
KW - Hematopoiesis
KW - Models, Biological
KW - Cell Tracking/methods
KW - Mosaicism
KW - Cell Separation/methods
KW - Research Design
KW - Stem Cells/cytology
U2 - 10.1016/j.exphem.2018.11.005
DO - 10.1016/j.exphem.2018.11.005
M3 - SCORING: Review article
C2 - 30448259
VL - 68
SP - 15
EP - 20
JO - EXP HEMATOL
JF - EXP HEMATOL
SN - 0301-472X
ER -