Research ExplorerPublicationsA shared neural basis underlying psychiatric comorbidity

A shared neural basis underlying psychiatric comorbidity

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A shared neural basis underlying psychiatric comorbidity. / Xie, Chao; Xiang, Shitong; Shen, Chun; Peng, Xuerui; Kang, Jujiao; Li, Yuzhu; Cheng, Wei; He, Shiqi; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Sahakian, Barbara J; Robbins, Trevor W; Schumann, Gunter; Jia, Tianye; Feng, Jianfeng; IMAGEN Consortium; STRATIFY/ESTRA Consortium; ZIB Consortium.

In: NAT MED, Vol. 29, No. 5, 05.2023, p. 1232-1242.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Xie, C, Xiang, S, Shen, C, Peng, X, Kang, J, Li, Y, Cheng, W, He, S, Banaschewski, T, Barker, GJ, Bokde, ALW, Bromberg, U, Büchel, C, Desrivières, S, Flor, H, Grigis, A, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Martinot, M-LP, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Sahakian, BJ, Robbins, TW, Schumann, G, Jia, T, Feng, J, IMAGEN Consortium, STRATIFY/ESTRA Consortium & ZIB Consortium 2023, 'A shared neural basis underlying psychiatric comorbidity', NAT MED, vol. 29, no. 5, pp. 1232-1242. https://doi.org/10.1038/s41591-023-02317-4

APA

Xie, C., Xiang, S., Shen, C., Peng, X., Kang, J., Li, Y., Cheng, W., He, S., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., ... ZIB Consortium (2023). A shared neural basis underlying psychiatric comorbidity. NAT MED, 29(5), 1232-1242. https://doi.org/10.1038/s41591-023-02317-4

Vancouver

Xie C, Xiang S, Shen C, Peng X, Kang J, Li Y et al. A shared neural basis underlying psychiatric comorbidity. NAT MED. 2023 May;29(5):1232-1242. https://doi.org/10.1038/s41591-023-02317-4

Bibtex

@article{112d3f7f514b40ea88925bfe43a8bc88,
title = "A shared neural basis underlying psychiatric comorbidity",
abstract = "Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the Stratify Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.",
author = "Chao Xie and Shitong Xiang and Chun Shen and Xuerui Peng and Jujiao Kang and Yuzhu Li and Wei Cheng and Shiqi He and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Sylvane Desrivi{\`e}res and Herta Flor and Antoine Grigis and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Sahakian, {Barbara J} and Robbins, {Trevor W} and Gunter Schumann and Tianye Jia and Jianfeng Feng and {IMAGEN Consortium} and {STRATIFY/ESTRA Consortium} and {ZIB Consortium}",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = may,
doi = "10.1038/s41591-023-02317-4",
language = "English",
volume = "29",
pages = "1232--1242",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - A shared neural basis underlying psychiatric comorbidity

AU - Xie, Chao

AU - Xiang, Shitong

AU - Shen, Chun

AU - Peng, Xuerui

AU - Kang, Jujiao

AU - Li, Yuzhu

AU - Cheng, Wei

AU - He, Shiqi

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Sahakian, Barbara J

AU - Robbins, Trevor W

AU - Schumann, Gunter

AU - Jia, Tianye

AU - Feng, Jianfeng

AU - IMAGEN Consortium

AU - STRATIFY/ESTRA Consortium

AU - ZIB Consortium

N1 - © 2023. The Author(s).

PY - 2023/5

Y1 - 2023/5

N2 - Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the Stratify Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.

AB - Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the Stratify Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.

U2 - 10.1038/s41591-023-02317-4

DO - 10.1038/s41591-023-02317-4

M3 - SCORING: Journal article

C2 - 37095248

VL - 29

SP - 1232

EP - 1242

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 5

ER -