A shared neural basis underlying psychiatric comorbidity
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A shared neural basis underlying psychiatric comorbidity. / Xie, Chao; Xiang, Shitong; Shen, Chun; Peng, Xuerui; Kang, Jujiao; Li, Yuzhu; Cheng, Wei; He, Shiqi; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Sahakian, Barbara J; Robbins, Trevor W; Schumann, Gunter; Jia, Tianye; Feng, Jianfeng; IMAGEN Consortium; STRATIFY/ESTRA Consortium; ZIB Consortium.
in: NAT MED, Jahrgang 29, Nr. 5, 05.2023, S. 1232-1242.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A shared neural basis underlying psychiatric comorbidity
AU - Xie, Chao
AU - Xiang, Shitong
AU - Shen, Chun
AU - Peng, Xuerui
AU - Kang, Jujiao
AU - Li, Yuzhu
AU - Cheng, Wei
AU - He, Shiqi
AU - Banaschewski, Tobias
AU - Barker, Gareth J
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Grigis, Antoine
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean-Luc
AU - Martinot, Marie-Laure Paillère
AU - Nees, Frauke
AU - Orfanos, Dimitri Papadopoulos
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Fröhner, Juliane H
AU - Smolka, Michael N
AU - Walter, Henrik
AU - Whelan, Robert
AU - Sahakian, Barbara J
AU - Robbins, Trevor W
AU - Schumann, Gunter
AU - Jia, Tianye
AU - Feng, Jianfeng
AU - IMAGEN Consortium
AU - STRATIFY/ESTRA Consortium
AU - ZIB Consortium
N1 - © 2023. The Author(s).
PY - 2023/5
Y1 - 2023/5
N2 - Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the Stratify Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.
AB - Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the Stratify Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.
U2 - 10.1038/s41591-023-02317-4
DO - 10.1038/s41591-023-02317-4
M3 - SCORING: Journal article
C2 - 37095248
VL - 29
SP - 1232
EP - 1242
JO - NAT MED
JF - NAT MED
SN - 1078-8956
IS - 5
ER -