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A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory

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A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory. / Freytag, Virginie; Carrillo-Roa, Tania; Milnik, Annette; Sämann, Philipp G; Vukojevic, Vanja; Coynel, David; Demougin, Philippe; Egli, Tobias; Gschwind, Leo; Jessen, Frank; Loos, Eva; Maier, Wolfgang; Riedel-Heller, Steffi G; Scherer, Martin; Vogler, Christian; Wagner, Michael; Binder, Elisabeth B; de Quervain, Dominique J-F; Papassotiropoulos, Andreas.

In: NAT COMMUN, Vol. 8, 26.04.2017, p. 15193.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Freytag, V, Carrillo-Roa, T, Milnik, A, Sämann, PG, Vukojevic, V, Coynel, D, Demougin, P, Egli, T, Gschwind, L, Jessen, F, Loos, E, Maier, W, Riedel-Heller, SG, Scherer, M, Vogler, C, Wagner, M, Binder, EB, de Quervain, DJ-F & Papassotiropoulos, A 2017, 'A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory', NAT COMMUN, vol. 8, pp. 15193. https://doi.org/10.1038/ncomms15193

APA

Freytag, V., Carrillo-Roa, T., Milnik, A., Sämann, P. G., Vukojevic, V., Coynel, D., Demougin, P., Egli, T., Gschwind, L., Jessen, F., Loos, E., Maier, W., Riedel-Heller, S. G., Scherer, M., Vogler, C., Wagner, M., Binder, E. B., de Quervain, D. J-F., & Papassotiropoulos, A. (2017). A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory. NAT COMMUN, 8, 15193. https://doi.org/10.1038/ncomms15193

Vancouver

Freytag V, Carrillo-Roa T, Milnik A, Sämann PG, Vukojevic V, Coynel D et al. A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory. NAT COMMUN. 2017 Apr 26;8:15193. https://doi.org/10.1038/ncomms15193

Bibtex

@article{0640164a872b48c6a0b2cc71d4b7e8a0,
title = "A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory",
abstract = "Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P=3.86 × 10(-8)) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P<0.001). A multilocus genetic score reflecting genetic variability of this signature is associated with memory performance (P=0.0003) in 3,346 young and elderly healthy adults. The genomic location of the contributing methylation sites points to the involvement of specific immune system genes. The decomposition of blood methylome-wide patterns bears considerable potential for the study of brain-related traits.",
keywords = "Journal Article",
author = "Virginie Freytag and Tania Carrillo-Roa and Annette Milnik and S{\"a}mann, {Philipp G} and Vanja Vukojevic and David Coynel and Philippe Demougin and Tobias Egli and Leo Gschwind and Frank Jessen and Eva Loos and Wolfgang Maier and Riedel-Heller, {Steffi G} and Martin Scherer and Christian Vogler and Michael Wagner and Binder, {Elisabeth B} and {de Quervain}, {Dominique J-F} and Andreas Papassotiropoulos",
year = "2017",
month = apr,
day = "26",
doi = "10.1038/ncomms15193",
language = "English",
volume = "8",
pages = "15193",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory

AU - Freytag, Virginie

AU - Carrillo-Roa, Tania

AU - Milnik, Annette

AU - Sämann, Philipp G

AU - Vukojevic, Vanja

AU - Coynel, David

AU - Demougin, Philippe

AU - Egli, Tobias

AU - Gschwind, Leo

AU - Jessen, Frank

AU - Loos, Eva

AU - Maier, Wolfgang

AU - Riedel-Heller, Steffi G

AU - Scherer, Martin

AU - Vogler, Christian

AU - Wagner, Michael

AU - Binder, Elisabeth B

AU - de Quervain, Dominique J-F

AU - Papassotiropoulos, Andreas

PY - 2017/4/26

Y1 - 2017/4/26

N2 - Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P=3.86 × 10(-8)) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P<0.001). A multilocus genetic score reflecting genetic variability of this signature is associated with memory performance (P=0.0003) in 3,346 young and elderly healthy adults. The genomic location of the contributing methylation sites points to the involvement of specific immune system genes. The decomposition of blood methylome-wide patterns bears considerable potential for the study of brain-related traits.

AB - Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P=3.86 × 10(-8)) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P<0.001). A multilocus genetic score reflecting genetic variability of this signature is associated with memory performance (P=0.0003) in 3,346 young and elderly healthy adults. The genomic location of the contributing methylation sites points to the involvement of specific immune system genes. The decomposition of blood methylome-wide patterns bears considerable potential for the study of brain-related traits.

KW - Journal Article

U2 - 10.1038/ncomms15193

DO - 10.1038/ncomms15193

M3 - SCORING: Journal article

C2 - 28443631

VL - 8

SP - 15193

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -