A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory
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A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory. / Freytag, Virginie; Carrillo-Roa, Tania; Milnik, Annette; Sämann, Philipp G; Vukojevic, Vanja; Coynel, David; Demougin, Philippe; Egli, Tobias; Gschwind, Leo; Jessen, Frank; Loos, Eva; Maier, Wolfgang; Riedel-Heller, Steffi G; Scherer, Martin; Vogler, Christian; Wagner, Michael; Binder, Elisabeth B; de Quervain, Dominique J-F; Papassotiropoulos, Andreas.
in: NAT COMMUN, Jahrgang 8, 26.04.2017, S. 15193.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory
AU - Freytag, Virginie
AU - Carrillo-Roa, Tania
AU - Milnik, Annette
AU - Sämann, Philipp G
AU - Vukojevic, Vanja
AU - Coynel, David
AU - Demougin, Philippe
AU - Egli, Tobias
AU - Gschwind, Leo
AU - Jessen, Frank
AU - Loos, Eva
AU - Maier, Wolfgang
AU - Riedel-Heller, Steffi G
AU - Scherer, Martin
AU - Vogler, Christian
AU - Wagner, Michael
AU - Binder, Elisabeth B
AU - de Quervain, Dominique J-F
AU - Papassotiropoulos, Andreas
PY - 2017/4/26
Y1 - 2017/4/26
N2 - Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P=3.86 × 10(-8)) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P<0.001). A multilocus genetic score reflecting genetic variability of this signature is associated with memory performance (P=0.0003) in 3,346 young and elderly healthy adults. The genomic location of the contributing methylation sites points to the involvement of specific immune system genes. The decomposition of blood methylome-wide patterns bears considerable potential for the study of brain-related traits.
AB - Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P=3.86 × 10(-8)) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P<0.001). A multilocus genetic score reflecting genetic variability of this signature is associated with memory performance (P=0.0003) in 3,346 young and elderly healthy adults. The genomic location of the contributing methylation sites points to the involvement of specific immune system genes. The decomposition of blood methylome-wide patterns bears considerable potential for the study of brain-related traits.
KW - Journal Article
U2 - 10.1038/ncomms15193
DO - 10.1038/ncomms15193
M3 - SCORING: Journal article
C2 - 28443631
VL - 8
SP - 15193
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
ER -