A new type of MAML2 fusion in mucoepidermoid carcinoma.
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A new type of MAML2 fusion in mucoepidermoid carcinoma. / Fehr, André; Röser, Kerstin; Heidorn, Klaus; Hallas, Cora; Löning, Thomas; Bullerdiek, Jörn.
In: GENE CHROMOSOME CANC, Vol. 47, No. 3, 3, 2008, p. 203-206.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - A new type of MAML2 fusion in mucoepidermoid carcinoma.
AU - Fehr, André
AU - Röser, Kerstin
AU - Heidorn, Klaus
AU - Hallas, Cora
AU - Löning, Thomas
AU - Bullerdiek, Jörn
PY - 2008
Y1 - 2008
N2 - The present study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing. We screened a total of 67 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas for the presence of chimeric genes. In one of these samples, a CRTC3-MAML2 fusion gene was detected. Thus, this report demonstrates the existence of a fusion of MAML2 with CREB regulated transcriptional coactivator CRTC3 additional to the already known fusion of MAML2 and CRTC1. Both gene fusions seem to result in an identical tumor phenotype and the fusion genes CRTC1-MAML2 and CRTC3-MAML2 may play a similar role in the development of mucoepidermoid carcinomas.
AB - The present study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing. We screened a total of 67 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas for the presence of chimeric genes. In one of these samples, a CRTC3-MAML2 fusion gene was detected. Thus, this report demonstrates the existence of a fusion of MAML2 with CREB regulated transcriptional coactivator CRTC3 additional to the already known fusion of MAML2 and CRTC1. Both gene fusions seem to result in an identical tumor phenotype and the fusion genes CRTC1-MAML2 and CRTC3-MAML2 may play a similar role in the development of mucoepidermoid carcinomas.
M3 - SCORING: Zeitschriftenaufsatz
VL - 47
SP - 203
EP - 206
JO - GENE CHROMOSOME CANC
JF - GENE CHROMOSOME CANC
SN - 1045-2257
IS - 3
M1 - 3
ER -