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A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases

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A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases. / Rades, Dirk; Huttenlocher, Stefan; Dziggel, Liesa; Blanck, Oliver; Hornung, Dagmar; Mai, Khoa Trong; Ngo, Trang Thuy; Van Pham, Thai; Schild, Steven.

In: Asian Pac J Cancer Prev, Vol. 16, No. 7, 2015, p. 2967-70.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rades, D, Huttenlocher, S, Dziggel, L, Blanck, O, Hornung, D, Mai, KT, Ngo, TT, Van Pham, T & Schild, S 2015, 'A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases', Asian Pac J Cancer Prev, vol. 16, no. 7, pp. 2967-70.

APA

Rades, D., Huttenlocher, S., Dziggel, L., Blanck, O., Hornung, D., Mai, K. T., Ngo, T. T., Van Pham, T., & Schild, S. (2015). A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases. Asian Pac J Cancer Prev, 16(7), 2967-70.

Vancouver

Rades D, Huttenlocher S, Dziggel L, Blanck O, Hornung D, Mai KT et al. A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases. Asian Pac J Cancer Prev. 2015;16(7):2967-70.

Bibtex

@article{d0fd5e59ba3a4c5fa0b66725ff6c6375,
title = "A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases",
abstract = "Many patients with few cerebral metastases receive radiosurgery alone. The goal of this study was to create a tool to estimate the survival of such patients. To identify characteristics associated with survival, nine variables including radiosurgery dose, age, gender, Eastern cooperative oncology group performance score (ECOG-PS), primary tumor type, number/size of cerebral metastases, location of cerebral metastases, extra-cerebral metastases and time between cancer diagnosis and radiosurgery were analyzed in 214 patients. On multivariate analysis, age (p=0.03), ECOG-PS (p=0.02) and extra-cerebral metastases (p<0.01) had significant impacts on survival. Scoring points for each patient were obtained from 12-month survival rates (in %) related to the significant variables divided by 10. Addition of the scoring points of the three variables resulted in a patient's total predictive score. Two groups were designed, A (10-14 points) and B (16-17 points). Twelve-month survival rates were 33% and 77%, respectively (p<0.001). Median survival times were 8 and 20 months, respectively. Because most patients of group A died from extra-cerebral disease and/or new cerebral lesions, early systemic treatment and additional WBI should be considered. As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group.",
keywords = "Brain Neoplasms, Cranial Irradiation, Female, Humans, Male, Middle Aged, Multivariate Analysis, Prognosis, Radiosurgery, Retrospective Studies, Survival Rate",
author = "Dirk Rades and Stefan Huttenlocher and Liesa Dziggel and Oliver Blanck and Dagmar Hornung and Mai, {Khoa Trong} and Ngo, {Trang Thuy} and {Van Pham}, Thai and Steven Schild",
year = "2015",
language = "English",
volume = "16",
pages = "2967--70",
journal = "Asian Pac J Cancer Prev",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "7",

}

RIS

TY - JOUR

T1 - A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases

AU - Rades, Dirk

AU - Huttenlocher, Stefan

AU - Dziggel, Liesa

AU - Blanck, Oliver

AU - Hornung, Dagmar

AU - Mai, Khoa Trong

AU - Ngo, Trang Thuy

AU - Van Pham, Thai

AU - Schild, Steven

PY - 2015

Y1 - 2015

N2 - Many patients with few cerebral metastases receive radiosurgery alone. The goal of this study was to create a tool to estimate the survival of such patients. To identify characteristics associated with survival, nine variables including radiosurgery dose, age, gender, Eastern cooperative oncology group performance score (ECOG-PS), primary tumor type, number/size of cerebral metastases, location of cerebral metastases, extra-cerebral metastases and time between cancer diagnosis and radiosurgery were analyzed in 214 patients. On multivariate analysis, age (p=0.03), ECOG-PS (p=0.02) and extra-cerebral metastases (p<0.01) had significant impacts on survival. Scoring points for each patient were obtained from 12-month survival rates (in %) related to the significant variables divided by 10. Addition of the scoring points of the three variables resulted in a patient's total predictive score. Two groups were designed, A (10-14 points) and B (16-17 points). Twelve-month survival rates were 33% and 77%, respectively (p<0.001). Median survival times were 8 and 20 months, respectively. Because most patients of group A died from extra-cerebral disease and/or new cerebral lesions, early systemic treatment and additional WBI should be considered. As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group.

AB - Many patients with few cerebral metastases receive radiosurgery alone. The goal of this study was to create a tool to estimate the survival of such patients. To identify characteristics associated with survival, nine variables including radiosurgery dose, age, gender, Eastern cooperative oncology group performance score (ECOG-PS), primary tumor type, number/size of cerebral metastases, location of cerebral metastases, extra-cerebral metastases and time between cancer diagnosis and radiosurgery were analyzed in 214 patients. On multivariate analysis, age (p=0.03), ECOG-PS (p=0.02) and extra-cerebral metastases (p<0.01) had significant impacts on survival. Scoring points for each patient were obtained from 12-month survival rates (in %) related to the significant variables divided by 10. Addition of the scoring points of the three variables resulted in a patient's total predictive score. Two groups were designed, A (10-14 points) and B (16-17 points). Twelve-month survival rates were 33% and 77%, respectively (p<0.001). Median survival times were 8 and 20 months, respectively. Because most patients of group A died from extra-cerebral disease and/or new cerebral lesions, early systemic treatment and additional WBI should be considered. As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group.

KW - Brain Neoplasms

KW - Cranial Irradiation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Prognosis

KW - Radiosurgery

KW - Retrospective Studies

KW - Survival Rate

M3 - SCORING: Journal article

C2 - 25854390

VL - 16

SP - 2967

EP - 2970

JO - Asian Pac J Cancer Prev

JF - Asian Pac J Cancer Prev

SN - 1513-7368

IS - 7

ER -