A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases
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A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases. / Rades, Dirk; Huttenlocher, Stefan; Dziggel, Liesa; Blanck, Oliver; Hornung, Dagmar; Mai, Khoa Trong; Ngo, Trang Thuy; Van Pham, Thai; Schild, Steven.
in: Asian Pac J Cancer Prev, Jahrgang 16, Nr. 7, 2015, S. 2967-70.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases
AU - Rades, Dirk
AU - Huttenlocher, Stefan
AU - Dziggel, Liesa
AU - Blanck, Oliver
AU - Hornung, Dagmar
AU - Mai, Khoa Trong
AU - Ngo, Trang Thuy
AU - Van Pham, Thai
AU - Schild, Steven
PY - 2015
Y1 - 2015
N2 - Many patients with few cerebral metastases receive radiosurgery alone. The goal of this study was to create a tool to estimate the survival of such patients. To identify characteristics associated with survival, nine variables including radiosurgery dose, age, gender, Eastern cooperative oncology group performance score (ECOG-PS), primary tumor type, number/size of cerebral metastases, location of cerebral metastases, extra-cerebral metastases and time between cancer diagnosis and radiosurgery were analyzed in 214 patients. On multivariate analysis, age (p=0.03), ECOG-PS (p=0.02) and extra-cerebral metastases (p<0.01) had significant impacts on survival. Scoring points for each patient were obtained from 12-month survival rates (in %) related to the significant variables divided by 10. Addition of the scoring points of the three variables resulted in a patient's total predictive score. Two groups were designed, A (10-14 points) and B (16-17 points). Twelve-month survival rates were 33% and 77%, respectively (p<0.001). Median survival times were 8 and 20 months, respectively. Because most patients of group A died from extra-cerebral disease and/or new cerebral lesions, early systemic treatment and additional WBI should be considered. As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group.
AB - Many patients with few cerebral metastases receive radiosurgery alone. The goal of this study was to create a tool to estimate the survival of such patients. To identify characteristics associated with survival, nine variables including radiosurgery dose, age, gender, Eastern cooperative oncology group performance score (ECOG-PS), primary tumor type, number/size of cerebral metastases, location of cerebral metastases, extra-cerebral metastases and time between cancer diagnosis and radiosurgery were analyzed in 214 patients. On multivariate analysis, age (p=0.03), ECOG-PS (p=0.02) and extra-cerebral metastases (p<0.01) had significant impacts on survival. Scoring points for each patient were obtained from 12-month survival rates (in %) related to the significant variables divided by 10. Addition of the scoring points of the three variables resulted in a patient's total predictive score. Two groups were designed, A (10-14 points) and B (16-17 points). Twelve-month survival rates were 33% and 77%, respectively (p<0.001). Median survival times were 8 and 20 months, respectively. Because most patients of group A died from extra-cerebral disease and/or new cerebral lesions, early systemic treatment and additional WBI should be considered. As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group.
KW - Brain Neoplasms
KW - Cranial Irradiation
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Prognosis
KW - Radiosurgery
KW - Retrospective Studies
KW - Survival Rate
M3 - SCORING: Journal article
C2 - 25854390
VL - 16
SP - 2967
EP - 2970
JO - Asian Pac J Cancer Prev
JF - Asian Pac J Cancer Prev
SN - 1513-7368
IS - 7
ER -