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A new antimicrobial and anticancer peptide producing by the marine deep sediment strain "Paenibacillus profundus" sp. nov. Sl 79

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A new antimicrobial and anticancer peptide producing by the marine deep sediment strain "Paenibacillus profundus" sp. nov. Sl 79. / Kalinovskaya, Nataliya I; Romanenko, Lyudmila A; Kalinovsky, Anatoly I; Dmitrenok, Pavel S; Dyshlovoy, Sergey A.

In: NAT PROD COMMUN, Vol. 8, No. 3, 03.2013, p. 381-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kalinovskaya, NI, Romanenko, LA, Kalinovsky, AI, Dmitrenok, PS & Dyshlovoy, SA 2013, 'A new antimicrobial and anticancer peptide producing by the marine deep sediment strain "Paenibacillus profundus" sp. nov. Sl 79', NAT PROD COMMUN, vol. 8, no. 3, pp. 381-4.

APA

Kalinovskaya, N. I., Romanenko, L. A., Kalinovsky, A. I., Dmitrenok, P. S., & Dyshlovoy, S. A. (2013). A new antimicrobial and anticancer peptide producing by the marine deep sediment strain "Paenibacillus profundus" sp. nov. Sl 79. NAT PROD COMMUN, 8(3), 381-4.

Vancouver

Kalinovskaya NI, Romanenko LA, Kalinovsky AI, Dmitrenok PS, Dyshlovoy SA. A new antimicrobial and anticancer peptide producing by the marine deep sediment strain "Paenibacillus profundus" sp. nov. Sl 79. NAT PROD COMMUN. 2013 Mar;8(3):381-4.

Bibtex

@article{72ba5dce78484e378b9e956182181155,
title = "A new antimicrobial and anticancer peptide producing by the marine deep sediment strain {"}Paenibacillus profundus{"} sp. nov. Sl 79",
abstract = "A new linear glyceryl acid derived heptapeptide (1), together with known isocoumarin antibiotic, Y-05460M-A (2), were isolated from the culture of the deep sea sediment strain SI 79 classified as {"}Paenibacillus profundus{"} sp. nov. Their structures were determined by 1D- and 2D- NMR techniques and ESI-MS/MS experiments. HPLC analysis of the Marfey derivatives in comparison to their analogs of authentic amino acids revealed that all amino acids in peptide 1, with an exception of Val, have the D-configuration. The compound 1 showed inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Enterococcus faecium as well as cytotoxic and moderate colony growth inhibitory activity against SK-MEL-28 cell line.",
keywords = "Anti-Bacterial Agents, Antineoplastic Agents, Phytogenic, Bacillus subtilis, Cell Line, Tumor, Cell Survival, Enterococcus faecium, Geologic Sediments, Humans, Paenibacillus, Staphylococcus aureus, Tandem Mass Spectrometry, Journal Article, Research Support, Non-U.S. Gov't",
author = "Kalinovskaya, {Nataliya I} and Romanenko, {Lyudmila A} and Kalinovsky, {Anatoly I} and Dmitrenok, {Pavel S} and Dyshlovoy, {Sergey A}",
year = "2013",
month = mar,
language = "English",
volume = "8",
pages = "381--4",
journal = "NAT PROD COMMUN",
issn = "1934-578X",
publisher = "Natural Product Communications",
number = "3",

}

RIS

TY - JOUR

T1 - A new antimicrobial and anticancer peptide producing by the marine deep sediment strain "Paenibacillus profundus" sp. nov. Sl 79

AU - Kalinovskaya, Nataliya I

AU - Romanenko, Lyudmila A

AU - Kalinovsky, Anatoly I

AU - Dmitrenok, Pavel S

AU - Dyshlovoy, Sergey A

PY - 2013/3

Y1 - 2013/3

N2 - A new linear glyceryl acid derived heptapeptide (1), together with known isocoumarin antibiotic, Y-05460M-A (2), were isolated from the culture of the deep sea sediment strain SI 79 classified as "Paenibacillus profundus" sp. nov. Their structures were determined by 1D- and 2D- NMR techniques and ESI-MS/MS experiments. HPLC analysis of the Marfey derivatives in comparison to their analogs of authentic amino acids revealed that all amino acids in peptide 1, with an exception of Val, have the D-configuration. The compound 1 showed inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Enterococcus faecium as well as cytotoxic and moderate colony growth inhibitory activity against SK-MEL-28 cell line.

AB - A new linear glyceryl acid derived heptapeptide (1), together with known isocoumarin antibiotic, Y-05460M-A (2), were isolated from the culture of the deep sea sediment strain SI 79 classified as "Paenibacillus profundus" sp. nov. Their structures were determined by 1D- and 2D- NMR techniques and ESI-MS/MS experiments. HPLC analysis of the Marfey derivatives in comparison to their analogs of authentic amino acids revealed that all amino acids in peptide 1, with an exception of Val, have the D-configuration. The compound 1 showed inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Enterococcus faecium as well as cytotoxic and moderate colony growth inhibitory activity against SK-MEL-28 cell line.

KW - Anti-Bacterial Agents

KW - Antineoplastic Agents, Phytogenic

KW - Bacillus subtilis

KW - Cell Line, Tumor

KW - Cell Survival

KW - Enterococcus faecium

KW - Geologic Sediments

KW - Humans

KW - Paenibacillus

KW - Staphylococcus aureus

KW - Tandem Mass Spectrometry

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 23678816

VL - 8

SP - 381

EP - 384

JO - NAT PROD COMMUN

JF - NAT PROD COMMUN

SN - 1934-578X

IS - 3

ER -