A new antimicrobial and anticancer peptide producing by the marine deep sediment strain "Paenibacillus profundus" sp. nov. Sl 79
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A new antimicrobial and anticancer peptide producing by the marine deep sediment strain "Paenibacillus profundus" sp. nov. Sl 79. / Kalinovskaya, Nataliya I; Romanenko, Lyudmila A; Kalinovsky, Anatoly I; Dmitrenok, Pavel S; Dyshlovoy, Sergey A.
in: NAT PROD COMMUN, Jahrgang 8, Nr. 3, 03.2013, S. 381-4.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A new antimicrobial and anticancer peptide producing by the marine deep sediment strain "Paenibacillus profundus" sp. nov. Sl 79
AU - Kalinovskaya, Nataliya I
AU - Romanenko, Lyudmila A
AU - Kalinovsky, Anatoly I
AU - Dmitrenok, Pavel S
AU - Dyshlovoy, Sergey A
PY - 2013/3
Y1 - 2013/3
N2 - A new linear glyceryl acid derived heptapeptide (1), together with known isocoumarin antibiotic, Y-05460M-A (2), were isolated from the culture of the deep sea sediment strain SI 79 classified as "Paenibacillus profundus" sp. nov. Their structures were determined by 1D- and 2D- NMR techniques and ESI-MS/MS experiments. HPLC analysis of the Marfey derivatives in comparison to their analogs of authentic amino acids revealed that all amino acids in peptide 1, with an exception of Val, have the D-configuration. The compound 1 showed inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Enterococcus faecium as well as cytotoxic and moderate colony growth inhibitory activity against SK-MEL-28 cell line.
AB - A new linear glyceryl acid derived heptapeptide (1), together with known isocoumarin antibiotic, Y-05460M-A (2), were isolated from the culture of the deep sea sediment strain SI 79 classified as "Paenibacillus profundus" sp. nov. Their structures were determined by 1D- and 2D- NMR techniques and ESI-MS/MS experiments. HPLC analysis of the Marfey derivatives in comparison to their analogs of authentic amino acids revealed that all amino acids in peptide 1, with an exception of Val, have the D-configuration. The compound 1 showed inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Enterococcus faecium as well as cytotoxic and moderate colony growth inhibitory activity against SK-MEL-28 cell line.
KW - Anti-Bacterial Agents
KW - Antineoplastic Agents, Phytogenic
KW - Bacillus subtilis
KW - Cell Line, Tumor
KW - Cell Survival
KW - Enterococcus faecium
KW - Geologic Sediments
KW - Humans
KW - Paenibacillus
KW - Staphylococcus aureus
KW - Tandem Mass Spectrometry
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - SCORING: Journal article
C2 - 23678816
VL - 8
SP - 381
EP - 384
JO - NAT PROD COMMUN
JF - NAT PROD COMMUN
SN - 1934-578X
IS - 3
ER -