A link between Krüppel-like factor 4, complement activation, and kidney damage

Diana Karpman; Sebastian Loos

doi:10.1016/j.kint.2022.04.014

A link between Krüppel-like factor 4, complement activation, and kidney damage

Standard

A link between Krüppel-like factor 4, complement activation, and kidney damage. / Karpman, Diana; Loos, Sebastian.

In: KIDNEY INT, Vol. 102, No. 1, 07.2022, p. 14-16.

Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

Harvard

Karpman, D & Loos, S 2022, 'A link between Krüppel-like factor 4, complement activation, and kidney damage', KIDNEY INT, vol. 102, no. 1, pp. 14-16. https://doi.org/10.1016/j.kint.2022.04.014

APA

Karpman, D., & Loos, S. (2022). A link between Krüppel-like factor 4, complement activation, and kidney damage. KIDNEY INT, 102(1), 14-16. https://doi.org/10.1016/j.kint.2022.04.014

Vancouver

Karpman D, Loos S. A link between Krüppel-like factor 4, complement activation, and kidney damage. KIDNEY INT. 2022 Jul;102(1):14-16. https://doi.org/10.1016/j.kint.2022.04.014

Bibtex

@article{99ebee1f1f2b44b682f03e717f2e7ae0,

title = "A link between Kr{\"u}ppel-like factor 4, complement activation, and kidney damage",

abstract = "Kr{\"u}ppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.",

author = "Diana Karpman and Sebastian Loos",

year = "2022",

month = jul,

doi = "10.1016/j.kint.2022.04.014",

language = "English",

volume = "102",

pages = "14--16",

journal = "KIDNEY INT",

issn = "0085-2538",

publisher = "NATURE PUBLISHING GROUP",

number = "1",

}

RIS

TY - JOUR

T1 - A link between Krüppel-like factor 4, complement activation, and kidney damage

AU - Karpman, Diana

AU - Loos, Sebastian

PY - 2022/7

Y1 - 2022/7

N2 - Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.

AB - Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.

U2 - 10.1016/j.kint.2022.04.014

DO - 10.1016/j.kint.2022.04.014

M3 - Other (editorial matter etc.)

C2 - 35738827

VL - 102

SP - 14

EP - 16

JO - KIDNEY INT

JF - KIDNEY INT

SN - 0085-2538

IS - 1

ER -