A link between Krüppel-like factor 4, complement activation, and kidney damage
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A link between Krüppel-like factor 4, complement activation, and kidney damage. / Karpman, Diana; Loos, Sebastian.
in: KIDNEY INT, Jahrgang 102, Nr. 1, 07.2022, S. 14-16.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Andere (Vorworte u.ä.) › Forschung
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TY - JOUR
T1 - A link between Krüppel-like factor 4, complement activation, and kidney damage
AU - Karpman, Diana
AU - Loos, Sebastian
N1 - Copyright © 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
PY - 2022/7
Y1 - 2022/7
N2 - Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.
AB - Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.
U2 - 10.1016/j.kint.2022.04.014
DO - 10.1016/j.kint.2022.04.014
M3 - Other (editorial matter etc.)
C2 - 35738827
VL - 102
SP - 14
EP - 16
JO - KIDNEY INT
JF - KIDNEY INT
SN - 0085-2538
IS - 1
ER -