Research ExplorerPublicationsA Dendritic Golgi Satellite between ERGIC and Retromer

A Dendritic Golgi Satellite between ERGIC and Retromer

Standard

A Dendritic Golgi Satellite between ERGIC and Retromer. / Mikhaylova, Marina; Bera, Sujoy; Kobler, Oliver; Frischknecht, Renato; Kreutz, Michael R .

In: CELL REP, Vol. 14, No. 2, 12.01.2016, p. 189-199.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mikhaylova, M, Bera, S, Kobler, O, Frischknecht, R & Kreutz, MR 2016, 'A Dendritic Golgi Satellite between ERGIC and Retromer', CELL REP, vol. 14, no. 2, pp. 189-199. https://doi.org/10.1016/j.celrep.2015.12.024

APA

Mikhaylova, M., Bera, S., Kobler, O., Frischknecht, R., & Kreutz, M. R. (2016). A Dendritic Golgi Satellite between ERGIC and Retromer. CELL REP, 14(2), 189-199. https://doi.org/10.1016/j.celrep.2015.12.024

Vancouver

Mikhaylova M, Bera S, Kobler O, Frischknecht R, Kreutz MR. A Dendritic Golgi Satellite between ERGIC and Retromer. CELL REP. 2016 Jan 12;14(2):189-199. https://doi.org/10.1016/j.celrep.2015.12.024

Bibtex

@article{49594895d88f49caab0e52ae6458b2ca,
title = "A Dendritic Golgi Satellite between ERGIC and Retromer",
abstract = "The local synthesis of transmembrane proteins underlies functional specialization of dendritic microdomains in neuronal plasticity. It is unclear whether these proteins have access to the complete machinery of the secretory pathway following local synthesis. In this study, we describe a probe called pGolt that allows visualization of Golgi-related organelles for live imaging in neurons. We show that pGolt labels a widespread microsecretory Golgi satellite (GS) system that is, in contrast to Golgi outposts, present throughout basal and apical dendrites of all pyramidal neurons. The GS system contains glycosylation machinery and is localized between ERGIC and retromer. Synaptic activity restrains lateral movement of ERGIC, GS, and retromer close to one another, allowing confined processing of secretory cargo. Several synaptic transmembrane proteins pass through and recycle back to the GS system. Thus, the presence of an ER-ERGIC-GS-retromer microsecretory system in all neuronal dendrites enables autonomous local control of transmembrane protein synthesis and processing. ",
author = "Marina Mikhaylova and Sujoy Bera and Oliver Kobler and Renato Frischknecht and Kreutz, {Michael R}",
year = "2016",
month = jan,
day = "12",
doi = "10.1016/j.celrep.2015.12.024",
language = "English",
volume = "14",
pages = "189--199",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - A Dendritic Golgi Satellite between ERGIC and Retromer

AU - Mikhaylova, Marina

AU - Bera, Sujoy

AU - Kobler, Oliver

AU - Frischknecht, Renato

AU - Kreutz, Michael R

PY - 2016/1/12

Y1 - 2016/1/12

N2 - The local synthesis of transmembrane proteins underlies functional specialization of dendritic microdomains in neuronal plasticity. It is unclear whether these proteins have access to the complete machinery of the secretory pathway following local synthesis. In this study, we describe a probe called pGolt that allows visualization of Golgi-related organelles for live imaging in neurons. We show that pGolt labels a widespread microsecretory Golgi satellite (GS) system that is, in contrast to Golgi outposts, present throughout basal and apical dendrites of all pyramidal neurons. The GS system contains glycosylation machinery and is localized between ERGIC and retromer. Synaptic activity restrains lateral movement of ERGIC, GS, and retromer close to one another, allowing confined processing of secretory cargo. Several synaptic transmembrane proteins pass through and recycle back to the GS system. Thus, the presence of an ER-ERGIC-GS-retromer microsecretory system in all neuronal dendrites enables autonomous local control of transmembrane protein synthesis and processing.

AB - The local synthesis of transmembrane proteins underlies functional specialization of dendritic microdomains in neuronal plasticity. It is unclear whether these proteins have access to the complete machinery of the secretory pathway following local synthesis. In this study, we describe a probe called pGolt that allows visualization of Golgi-related organelles for live imaging in neurons. We show that pGolt labels a widespread microsecretory Golgi satellite (GS) system that is, in contrast to Golgi outposts, present throughout basal and apical dendrites of all pyramidal neurons. The GS system contains glycosylation machinery and is localized between ERGIC and retromer. Synaptic activity restrains lateral movement of ERGIC, GS, and retromer close to one another, allowing confined processing of secretory cargo. Several synaptic transmembrane proteins pass through and recycle back to the GS system. Thus, the presence of an ER-ERGIC-GS-retromer microsecretory system in all neuronal dendrites enables autonomous local control of transmembrane protein synthesis and processing.

U2 - 10.1016/j.celrep.2015.12.024

DO - 10.1016/j.celrep.2015.12.024

M3 - SCORING: Journal article

VL - 14

SP - 189

EP - 199

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 2

ER -