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A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells

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A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells. / Wiech, Thorsten; Nikolopoulos, Elisabeth; Hausmann, Michael; Walch, Axel; Werner, Martin; Fisch, Paul.

In: BREAST J, Vol. 14, No. 5, 2008, p. 487-91.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wiech, T, Nikolopoulos, E, Hausmann, M, Walch, A, Werner, M & Fisch, P 2008, 'A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells', BREAST J, vol. 14, no. 5, pp. 487-91. https://doi.org/10.1111/j.1524-4741.2008.00627.x

APA

Wiech, T., Nikolopoulos, E., Hausmann, M., Walch, A., Werner, M., & Fisch, P. (2008). A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells. BREAST J, 14(5), 487-91. https://doi.org/10.1111/j.1524-4741.2008.00627.x

Vancouver

Wiech T, Nikolopoulos E, Hausmann M, Walch A, Werner M, Fisch P. A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells. BREAST J. 2008;14(5):487-91. https://doi.org/10.1111/j.1524-4741.2008.00627.x

Bibtex

@article{ef2fa6f0f9cc4afe9901957944413005,
title = "A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells",
abstract = "We report a case of an invasive ductal breast carcinoma with significant heterogeneity: a HER-2+ tumor component was densely infiltrated by T-cells, whereas the HER2- tumor component, including two axillary lymph node metastases, showed much fewer tumor infiltrating lymphocytes. Array comparative genomic hybridization of dissected tumor cells from both components revealed many shared chromosomal aberrations but also unique alterations of the HER2+ tumor cell population besides HER2 amplification. We found a clonally dominated T-cell receptor rearrangement of the tumor infiltrating lymphocytes in the HER2+, but not in the HER2- tumor component. Thus, in this case HER2 overexpression is associated with a marked infiltration by T-cells suggesting a specific T-cell response against the HER2+ tumor cell population.",
keywords = "Biopsy, Needle, Breast Neoplasms, Carcinoma, Ductal, Breast, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Lymphatic Metastasis, Lymphocytes, Tumor-Infiltrating, Mastectomy, Middle Aged, Neoplasm Staging, Prognosis, Receptor, erbB-2, Risk Assessment",
author = "Thorsten Wiech and Elisabeth Nikolopoulos and Michael Hausmann and Axel Walch and Martin Werner and Paul Fisch",
year = "2008",
doi = "10.1111/j.1524-4741.2008.00627.x",
language = "English",
volume = "14",
pages = "487--91",
journal = "BREAST J",
issn = "1075-122X",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells

AU - Wiech, Thorsten

AU - Nikolopoulos, Elisabeth

AU - Hausmann, Michael

AU - Walch, Axel

AU - Werner, Martin

AU - Fisch, Paul

PY - 2008

Y1 - 2008

N2 - We report a case of an invasive ductal breast carcinoma with significant heterogeneity: a HER-2+ tumor component was densely infiltrated by T-cells, whereas the HER2- tumor component, including two axillary lymph node metastases, showed much fewer tumor infiltrating lymphocytes. Array comparative genomic hybridization of dissected tumor cells from both components revealed many shared chromosomal aberrations but also unique alterations of the HER2+ tumor cell population besides HER2 amplification. We found a clonally dominated T-cell receptor rearrangement of the tumor infiltrating lymphocytes in the HER2+, but not in the HER2- tumor component. Thus, in this case HER2 overexpression is associated with a marked infiltration by T-cells suggesting a specific T-cell response against the HER2+ tumor cell population.

AB - We report a case of an invasive ductal breast carcinoma with significant heterogeneity: a HER-2+ tumor component was densely infiltrated by T-cells, whereas the HER2- tumor component, including two axillary lymph node metastases, showed much fewer tumor infiltrating lymphocytes. Array comparative genomic hybridization of dissected tumor cells from both components revealed many shared chromosomal aberrations but also unique alterations of the HER2+ tumor cell population besides HER2 amplification. We found a clonally dominated T-cell receptor rearrangement of the tumor infiltrating lymphocytes in the HER2+, but not in the HER2- tumor component. Thus, in this case HER2 overexpression is associated with a marked infiltration by T-cells suggesting a specific T-cell response against the HER2+ tumor cell population.

KW - Biopsy, Needle

KW - Breast Neoplasms

KW - Carcinoma, Ductal, Breast

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Immunohistochemistry

KW - In Situ Hybridization, Fluorescence

KW - Lymphatic Metastasis

KW - Lymphocytes, Tumor-Infiltrating

KW - Mastectomy

KW - Middle Aged

KW - Neoplasm Staging

KW - Prognosis

KW - Receptor, erbB-2

KW - Risk Assessment

U2 - 10.1111/j.1524-4741.2008.00627.x

DO - 10.1111/j.1524-4741.2008.00627.x

M3 - SCORING: Journal article

C2 - 18821935

VL - 14

SP - 487

EP - 491

JO - BREAST J

JF - BREAST J

SN - 1075-122X

IS - 5

ER -