A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells
Standard
A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells. / Wiech, Thorsten; Nikolopoulos, Elisabeth; Hausmann, Michael; Walch, Axel; Werner, Martin; Fisch, Paul.
in: BREAST J, Jahrgang 14, Nr. 5, 2008, S. 487-91.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells
AU - Wiech, Thorsten
AU - Nikolopoulos, Elisabeth
AU - Hausmann, Michael
AU - Walch, Axel
AU - Werner, Martin
AU - Fisch, Paul
PY - 2008
Y1 - 2008
N2 - We report a case of an invasive ductal breast carcinoma with significant heterogeneity: a HER-2+ tumor component was densely infiltrated by T-cells, whereas the HER2- tumor component, including two axillary lymph node metastases, showed much fewer tumor infiltrating lymphocytes. Array comparative genomic hybridization of dissected tumor cells from both components revealed many shared chromosomal aberrations but also unique alterations of the HER2+ tumor cell population besides HER2 amplification. We found a clonally dominated T-cell receptor rearrangement of the tumor infiltrating lymphocytes in the HER2+, but not in the HER2- tumor component. Thus, in this case HER2 overexpression is associated with a marked infiltration by T-cells suggesting a specific T-cell response against the HER2+ tumor cell population.
AB - We report a case of an invasive ductal breast carcinoma with significant heterogeneity: a HER-2+ tumor component was densely infiltrated by T-cells, whereas the HER2- tumor component, including two axillary lymph node metastases, showed much fewer tumor infiltrating lymphocytes. Array comparative genomic hybridization of dissected tumor cells from both components revealed many shared chromosomal aberrations but also unique alterations of the HER2+ tumor cell population besides HER2 amplification. We found a clonally dominated T-cell receptor rearrangement of the tumor infiltrating lymphocytes in the HER2+, but not in the HER2- tumor component. Thus, in this case HER2 overexpression is associated with a marked infiltration by T-cells suggesting a specific T-cell response against the HER2+ tumor cell population.
KW - Biopsy, Needle
KW - Breast Neoplasms
KW - Carcinoma, Ductal, Breast
KW - Female
KW - Gene Expression Regulation, Neoplastic
KW - Humans
KW - Immunohistochemistry
KW - In Situ Hybridization, Fluorescence
KW - Lymphatic Metastasis
KW - Lymphocytes, Tumor-Infiltrating
KW - Mastectomy
KW - Middle Aged
KW - Neoplasm Staging
KW - Prognosis
KW - Receptor, erbB-2
KW - Risk Assessment
U2 - 10.1111/j.1524-4741.2008.00627.x
DO - 10.1111/j.1524-4741.2008.00627.x
M3 - SCORING: Journal article
C2 - 18821935
VL - 14
SP - 487
EP - 491
JO - BREAST J
JF - BREAST J
SN - 1075-122X
IS - 5
ER -