2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
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2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. / Li, Jingmei; Lindström, Linda S; Foo, Jia N; Rafiq, Sajjad; Schmidt, Marjanka K; Pharoah, Paul D P; Michailidou, Kyriaki; Dennis, Joe; Bolla, Manjeet K; Wang, Qin; Van 't Veer, Laura J; Cornelissen, Sten; Rutgers, Emiel; Southey, Melissa C; Apicella, Carmel; Dite, Gillian S; Hopper, John L; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Beckmann, Matthias W; Blomqvist, Carl; Muranen, Taru A; Aittomäki, Kristiina; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kosma, Veli-Matti; Hartikainen, Jaana M; Kataja, Vesa; Chenevix-Trench, Georgia; Phillips, Kelly-Anne; McLachlan, Sue-Anne; Lambrechts, Diether; Thienpont, Bernard; Smeets, Ann; Wildiers, Hans; Chang-Claude, Jenny; Flesch-Janys, Dieter; Seibold, Petra; Rudolph, Anja; Giles, Graham G; Baglietto, Laura; Severi, Gianluca; Haiman, Christopher A; Henderson, Brian E; Schumacher, Fredrick; Le Marchand, Loic; Kristensen, Vessela; Alnæs, Grethe I Grenaker; Borresen-Dale, Anne-Lise; Nord, Silje; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Tchatchou, Sandrine; Devilee, Peter; Tollenaar, Robert; Seynaeve, Caroline; Hooning, Maartje; Kriege, Mieke; Hollestelle, Antoinette; van den Ouweland, Ans; Li, Yi; Hamann, Ute; Torres, Diana; Ulmer, Hans U; Rüdiger, Thomas; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Chen, Shou-Tung; Teo, Soo Hwang; Taib, Nur Aishah Mohd; Har Yip, Cheng; Fuang Ho, Gwo; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Tajima, Kazuo; Kang, Daehee; Choi, Ji-Yeob; Park, Sue K; Yoo, Keun-Young; Maishman, Tom; Tapper, William J; Dunning, Alison; Shah, Mitul; Luben, Robert; Brown, Judith; Khor, Chiea Chuen; Eccles, Diana M; Nevanlinna, Heli; Easton, Douglas; Humphreys, Keith; Liu, Jianjun; Hall, Per; Czene, Kamila; KConFab Investigators.
In: NAT COMMUN, Vol. 5, 01.01.2014, p. 4051.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
AU - Li, Jingmei
AU - Lindström, Linda S
AU - Foo, Jia N
AU - Rafiq, Sajjad
AU - Schmidt, Marjanka K
AU - Pharoah, Paul D P
AU - Michailidou, Kyriaki
AU - Dennis, Joe
AU - Bolla, Manjeet K
AU - Wang, Qin
AU - Van 't Veer, Laura J
AU - Cornelissen, Sten
AU - Rutgers, Emiel
AU - Southey, Melissa C
AU - Apicella, Carmel
AU - Dite, Gillian S
AU - Hopper, John L
AU - Fasching, Peter A
AU - Haeberle, Lothar
AU - Ekici, Arif B
AU - Beckmann, Matthias W
AU - Blomqvist, Carl
AU - Muranen, Taru A
AU - Aittomäki, Kristiina
AU - Lindblom, Annika
AU - Margolin, Sara
AU - Mannermaa, Arto
AU - Kosma, Veli-Matti
AU - Hartikainen, Jaana M
AU - Kataja, Vesa
AU - Chenevix-Trench, Georgia
AU - Phillips, Kelly-Anne
AU - McLachlan, Sue-Anne
AU - Lambrechts, Diether
AU - Thienpont, Bernard
AU - Smeets, Ann
AU - Wildiers, Hans
AU - Chang-Claude, Jenny
AU - Flesch-Janys, Dieter
AU - Seibold, Petra
AU - Rudolph, Anja
AU - Giles, Graham G
AU - Baglietto, Laura
AU - Severi, Gianluca
AU - Haiman, Christopher A
AU - Henderson, Brian E
AU - Schumacher, Fredrick
AU - Le Marchand, Loic
AU - Kristensen, Vessela
AU - Alnæs, Grethe I Grenaker
AU - Borresen-Dale, Anne-Lise
AU - Nord, Silje
AU - Winqvist, Robert
AU - Pylkäs, Katri
AU - Jukkola-Vuorinen, Arja
AU - Grip, Mervi
AU - Andrulis, Irene L
AU - Knight, Julia A
AU - Glendon, Gord
AU - Tchatchou, Sandrine
AU - Devilee, Peter
AU - Tollenaar, Robert
AU - Seynaeve, Caroline
AU - Hooning, Maartje
AU - Kriege, Mieke
AU - Hollestelle, Antoinette
AU - van den Ouweland, Ans
AU - Li, Yi
AU - Hamann, Ute
AU - Torres, Diana
AU - Ulmer, Hans U
AU - Rüdiger, Thomas
AU - Shen, Chen-Yang
AU - Hsiung, Chia-Ni
AU - Wu, Pei-Ei
AU - Chen, Shou-Tung
AU - Teo, Soo Hwang
AU - Taib, Nur Aishah Mohd
AU - Har Yip, Cheng
AU - Fuang Ho, Gwo
AU - Matsuo, Keitaro
AU - Ito, Hidemi
AU - Iwata, Hiroji
AU - Tajima, Kazuo
AU - Kang, Daehee
AU - Choi, Ji-Yeob
AU - Park, Sue K
AU - Yoo, Keun-Young
AU - Maishman, Tom
AU - Tapper, William J
AU - Dunning, Alison
AU - Shah, Mitul
AU - Luben, Robert
AU - Brown, Judith
AU - Khor, Chiea Chuen
AU - Eccles, Diana M
AU - Nevanlinna, Heli
AU - Easton, Douglas
AU - Humphreys, Keith
AU - Liu, Jianjun
AU - Hall, Per
AU - Czene, Kamila
AU - KConFab Investigators
N1 - Dieter Flesch-Janys 35 ] Univ Clin Hamburg Eppendorf, Dept Canc Epidemiol Clin Canc Registry, D-20246 Hamburg, Germany [ 36 ] Univ Clin Hamburg Eppendorf, Inst Med Biometr & Epidemiol, D-20246 Hamburg, Germany
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.
AB - Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.
U2 - 10.1038/ncomms5051
DO - 10.1038/ncomms5051
M3 - SCORING: Journal article
C2 - 24937182
VL - 5
SP - 4051
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
ER -