PortalPublikationen2q36.3 is associated with prognosis for oestrogen receptor-n...

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Standard

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. / Li, Jingmei; Lindström, Linda S; Foo, Jia N; Rafiq, Sajjad; Schmidt, Marjanka K; Pharoah, Paul D P; Michailidou, Kyriaki; Dennis, Joe; Bolla, Manjeet K; Wang, Qin; Van 't Veer, Laura J; Cornelissen, Sten; Rutgers, Emiel; Southey, Melissa C; Apicella, Carmel; Dite, Gillian S; Hopper, John L; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Beckmann, Matthias W; Blomqvist, Carl; Muranen, Taru A; Aittomäki, Kristiina; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kosma, Veli-Matti; Hartikainen, Jaana M; Kataja, Vesa; Chenevix-Trench, Georgia; Phillips, Kelly-Anne; McLachlan, Sue-Anne; Lambrechts, Diether; Thienpont, Bernard; Smeets, Ann; Wildiers, Hans; Chang-Claude, Jenny; Flesch-Janys, Dieter; Seibold, Petra; Rudolph, Anja; Giles, Graham G; Baglietto, Laura; Severi, Gianluca; Haiman, Christopher A; Henderson, Brian E; Schumacher, Fredrick; Le Marchand, Loic; Kristensen, Vessela; Alnæs, Grethe I Grenaker; Borresen-Dale, Anne-Lise; Nord, Silje; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Tchatchou, Sandrine; Devilee, Peter; Tollenaar, Robert; Seynaeve, Caroline; Hooning, Maartje; Kriege, Mieke; Hollestelle, Antoinette; van den Ouweland, Ans; Li, Yi; Hamann, Ute; Torres, Diana; Ulmer, Hans U; Rüdiger, Thomas; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Chen, Shou-Tung; Teo, Soo Hwang; Taib, Nur Aishah Mohd; Har Yip, Cheng; Fuang Ho, Gwo; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Tajima, Kazuo; Kang, Daehee; Choi, Ji-Yeob; Park, Sue K; Yoo, Keun-Young; Maishman, Tom; Tapper, William J; Dunning, Alison; Shah, Mitul; Luben, Robert; Brown, Judith; Khor, Chiea Chuen; Eccles, Diana M; Nevanlinna, Heli; Easton, Douglas; Humphreys, Keith; Liu, Jianjun; Hall, Per; Czene, Kamila; KConFab Investigators.

in: NAT COMMUN, Jahrgang 5, 01.01.2014, S. 4051.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Li, J, Lindström, LS, Foo, JN, Rafiq, S, Schmidt, MK, Pharoah, PDP, Michailidou, K, Dennis, J, Bolla, MK, Wang, Q, Van 't Veer, LJ, Cornelissen, S, Rutgers, E, Southey, MC, Apicella, C, Dite, GS, Hopper, JL, Fasching, PA, Haeberle, L, Ekici, AB, Beckmann, MW, Blomqvist, C, Muranen, TA, Aittomäki, K, Lindblom, A, Margolin, S, Mannermaa, A, Kosma, V-M, Hartikainen, JM, Kataja, V, Chenevix-Trench, G, Phillips, K-A, McLachlan, S-A, Lambrechts, D, Thienpont, B, Smeets, A, Wildiers, H, Chang-Claude, J, Flesch-Janys, D, Seibold, P, Rudolph, A, Giles, GG, Baglietto, L, Severi, G, Haiman, CA, Henderson, BE, Schumacher, F, Le Marchand, L, Kristensen, V, Alnæs, GIG, Borresen-Dale, A-L, Nord, S, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Andrulis, IL, Knight, JA, Glendon, G, Tchatchou, S, Devilee, P, Tollenaar, R, Seynaeve, C, Hooning, M, Kriege, M, Hollestelle, A, van den Ouweland, A, Li, Y, Hamann, U, Torres, D, Ulmer, HU, Rüdiger, T, Shen, C-Y, Hsiung, C-N, Wu, P-E, Chen, S-T, Teo, SH, Taib, NAM, Har Yip, C, Fuang Ho, G, Matsuo, K, Ito, H, Iwata, H, Tajima, K, Kang, D, Choi, J-Y, Park, SK, Yoo, K-Y, Maishman, T, Tapper, WJ, Dunning, A, Shah, M, Luben, R, Brown, J, Khor, CC, Eccles, DM, Nevanlinna, H, Easton, D, Humphreys, K, Liu, J, Hall, P, Czene, K & KConFab Investigators 2014, '2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy', NAT COMMUN, Jg. 5, S. 4051. https://doi.org/10.1038/ncomms5051

APA

Li, J., Lindström, L. S., Foo, J. N., Rafiq, S., Schmidt, M. K., Pharoah, P. D. P., Michailidou, K., Dennis, J., Bolla, M. K., Wang, Q., Van 't Veer, L. J., Cornelissen, S., Rutgers, E., Southey, M. C., Apicella, C., Dite, G. S., Hopper, J. L., Fasching, P. A., Haeberle, L., ... KConFab Investigators (2014). 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. NAT COMMUN, 5, 4051. https://doi.org/10.1038/ncomms5051

Vancouver

Li J, Lindström LS, Foo JN, Rafiq S, Schmidt MK, Pharoah PDP et al. 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. NAT COMMUN. 2014 Jan 1;5:4051. https://doi.org/10.1038/ncomms5051

Bibtex

@article{ecbd013805054286935f7564e6542084,
title = "2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy",
abstract = "Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.",
author = "Jingmei Li and Lindstr{\"o}m, {Linda S} and Foo, {Jia N} and Sajjad Rafiq and Schmidt, {Marjanka K} and Pharoah, {Paul D P} and Kyriaki Michailidou and Joe Dennis and Bolla, {Manjeet K} and Qin Wang and {Van 't Veer}, {Laura J} and Sten Cornelissen and Emiel Rutgers and Southey, {Melissa C} and Carmel Apicella and Dite, {Gillian S} and Hopper, {John L} and Fasching, {Peter A} and Lothar Haeberle and Ekici, {Arif B} and Beckmann, {Matthias W} and Carl Blomqvist and Muranen, {Taru A} and Kristiina Aittom{\"a}ki and Annika Lindblom and Sara Margolin and Arto Mannermaa and Veli-Matti Kosma and Hartikainen, {Jaana M} and Vesa Kataja and Georgia Chenevix-Trench and Kelly-Anne Phillips and Sue-Anne McLachlan and Diether Lambrechts and Bernard Thienpont and Ann Smeets and Hans Wildiers and Jenny Chang-Claude and Dieter Flesch-Janys and Petra Seibold and Anja Rudolph and Giles, {Graham G} and Laura Baglietto and Gianluca Severi and Haiman, {Christopher A} and Henderson, {Brian E} and Fredrick Schumacher and {Le Marchand}, Loic and Vessela Kristensen and Aln{\ae}s, {Grethe I Grenaker} and Anne-Lise Borresen-Dale and Silje Nord and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Andrulis, {Irene L} and Knight, {Julia A} and Gord Glendon and Sandrine Tchatchou and Peter Devilee and Robert Tollenaar and Caroline Seynaeve and Maartje Hooning and Mieke Kriege and Antoinette Hollestelle and {van den Ouweland}, Ans and Yi Li and Ute Hamann and Diana Torres and Ulmer, {Hans U} and Thomas R{\"u}diger and Chen-Yang Shen and Chia-Ni Hsiung and Pei-Ei Wu and Shou-Tung Chen and Teo, {Soo Hwang} and Taib, {Nur Aishah Mohd} and {Har Yip}, Cheng and {Fuang Ho}, Gwo and Keitaro Matsuo and Hidemi Ito and Hiroji Iwata and Kazuo Tajima and Daehee Kang and Ji-Yeob Choi and Park, {Sue K} and Keun-Young Yoo and Tom Maishman and Tapper, {William J} and Alison Dunning and Mitul Shah and Robert Luben and Judith Brown and Khor, {Chiea Chuen} and Eccles, {Diana M} and Heli Nevanlinna and Douglas Easton and Keith Humphreys and Jianjun Liu and Per Hall and Kamila Czene and {KConFab Investigators}",
note = "Dieter Flesch-Janys 35 ] Univ Clin Hamburg Eppendorf, Dept Canc Epidemiol Clin Canc Registry, D-20246 Hamburg, Germany [ 36 ] Univ Clin Hamburg Eppendorf, Inst Med Biometr & Epidemiol, D-20246 Hamburg, Germany ",
year = "2014",
month = jan,
day = "1",
doi = "10.1038/ncomms5051",
language = "English",
volume = "5",
pages = "4051",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

AU - Li, Jingmei

AU - Lindström, Linda S

AU - Foo, Jia N

AU - Rafiq, Sajjad

AU - Schmidt, Marjanka K

AU - Pharoah, Paul D P

AU - Michailidou, Kyriaki

AU - Dennis, Joe

AU - Bolla, Manjeet K

AU - Wang, Qin

AU - Van 't Veer, Laura J

AU - Cornelissen, Sten

AU - Rutgers, Emiel

AU - Southey, Melissa C

AU - Apicella, Carmel

AU - Dite, Gillian S

AU - Hopper, John L

AU - Fasching, Peter A

AU - Haeberle, Lothar

AU - Ekici, Arif B

AU - Beckmann, Matthias W

AU - Blomqvist, Carl

AU - Muranen, Taru A

AU - Aittomäki, Kristiina

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Kosma, Veli-Matti

AU - Hartikainen, Jaana M

AU - Kataja, Vesa

AU - Chenevix-Trench, Georgia

AU - Phillips, Kelly-Anne

AU - McLachlan, Sue-Anne

AU - Lambrechts, Diether

AU - Thienpont, Bernard

AU - Smeets, Ann

AU - Wildiers, Hans

AU - Chang-Claude, Jenny

AU - Flesch-Janys, Dieter

AU - Seibold, Petra

AU - Rudolph, Anja

AU - Giles, Graham G

AU - Baglietto, Laura

AU - Severi, Gianluca

AU - Haiman, Christopher A

AU - Henderson, Brian E

AU - Schumacher, Fredrick

AU - Le Marchand, Loic

AU - Kristensen, Vessela

AU - Alnæs, Grethe I Grenaker

AU - Borresen-Dale, Anne-Lise

AU - Nord, Silje

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Andrulis, Irene L

AU - Knight, Julia A

AU - Glendon, Gord

AU - Tchatchou, Sandrine

AU - Devilee, Peter

AU - Tollenaar, Robert

AU - Seynaeve, Caroline

AU - Hooning, Maartje

AU - Kriege, Mieke

AU - Hollestelle, Antoinette

AU - van den Ouweland, Ans

AU - Li, Yi

AU - Hamann, Ute

AU - Torres, Diana

AU - Ulmer, Hans U

AU - Rüdiger, Thomas

AU - Shen, Chen-Yang

AU - Hsiung, Chia-Ni

AU - Wu, Pei-Ei

AU - Chen, Shou-Tung

AU - Teo, Soo Hwang

AU - Taib, Nur Aishah Mohd

AU - Har Yip, Cheng

AU - Fuang Ho, Gwo

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Iwata, Hiroji

AU - Tajima, Kazuo

AU - Kang, Daehee

AU - Choi, Ji-Yeob

AU - Park, Sue K

AU - Yoo, Keun-Young

AU - Maishman, Tom

AU - Tapper, William J

AU - Dunning, Alison

AU - Shah, Mitul

AU - Luben, Robert

AU - Brown, Judith

AU - Khor, Chiea Chuen

AU - Eccles, Diana M

AU - Nevanlinna, Heli

AU - Easton, Douglas

AU - Humphreys, Keith

AU - Liu, Jianjun

AU - Hall, Per

AU - Czene, Kamila

AU - KConFab Investigators

N1 - Dieter Flesch-Janys 35 ] Univ Clin Hamburg Eppendorf, Dept Canc Epidemiol Clin Canc Registry, D-20246 Hamburg, Germany [ 36 ] Univ Clin Hamburg Eppendorf, Inst Med Biometr & Epidemiol, D-20246 Hamburg, Germany

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

AB - Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

U2 - 10.1038/ncomms5051

DO - 10.1038/ncomms5051

M3 - SCORING: Journal article

C2 - 24937182

VL - 5

SP - 4051

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -