ID: 62859
Jakob Körbelin
Group leader
Publications
- 2023
A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS
Johann, L., Soldati, S., Müller, K., Lampe, J., Marini, F., Klein, M., Schramm, E., Ries, N., Schelmbauer, C., Palagi, I., Karram, K., Assmann, J. C., Khan, M. A., Wenzel, J., Schmidt, M. H., Körbelin, J., Schlüter, D., van Loo, G., Bopp, T., Engelhardt, B., Schwaninger, M. & Waisman, A., 15.12.2023, In: J CLIN INVEST. 133, 24, e168314.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension
Isobe, S., Nair, R. V., Kang, H. Y., Wang, L., Moonen, J-R., Shinohara, T., Cao, A., Taylor, S., Otsuki, S., Marciano, D. P., Harper, R. L., Adil, M. S., Zhang, C., Lago-Docampo, M., Körbelin, J., Engreitz, J. M., Snyder, M. P. & Rabinovitch, M., 21.11.2023, In: NAT COMMUN. 14, 1, 7578.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations
Ren, J., Huang, Y., Ren, Y., Tu, T., Qiu, B., Ai, D., Bi, Z., Bai, X., Li, F., Li, J-L., Chen, X-J., Feng, Z., Guo, Z., Lei, J., Tian, A., Cui, Z., Lindner, V., Adams, R. H., Wang, Y., Zhao, F., Körbelin, J., Sun, W., Wang, Y., Zhang, H., Hong, T. & Ge, W-P., 01.09.2023, In: BRAIN. 146, 9, p. 3634-3647 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
Aydin, S., Pareja, J., Schallenberg, V. M., Klopstein, A., Gruber, T., Page, N., Bouillet, E., Blanchard, N., Liblau, R., Körbelin, J., Schwaninger, M., Johnson, A. J., Schenk, M., Deutsch, U., Merkler, D. & Engelhardt, B., 30.05.2023, In: NAT COMMUN. 14, 1, 3106.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Transcription factors in the pathogenesis of pulmonary arterial hypertension-Current knowledge and therapeutic potential
Körbelin, J., Matuszcak, C., Runge, J., Harbaum, L., Klose, H. & Hennigs, J. K., 06.01.2023, In: FRONT CARDIOVASC MED. 9, p. 1036096Research output: SCORING: Contribution to journal › SCORING: Review article › Research
A novel strategy for delivering Niemann-Pick type C2 proteins across the blood-brain barrier using the brain endothelial-specific AAV-BR1 virus
Rasmussen, C. L. M., Hede, E., Routhe, L. J., Körbelin, J., Helgudottir, S. S., Thomsen, L. B., Schwaninger, M., Burkhart, A. & Moos, T., 01.2023, In: J NEUROCHEM. 164, 1, p. 6-28 23 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2022
Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency
Sundaram, S. M., Arrulo Pereira, A., Müller-Fielitz, H., Köpke, H., De Angelis, M., Müller, T. D., Heuer, H., Körbelin, J., Krohn, M., Mittag, J., Nogueiras, R., Prevot, V. & Schwaninger, M., 19.12.2022, In: BRAIN. 145, 12, p. 4264-4274 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Respiratory muscle dysfunction in long-COVID patients
Hennigs, J. K., Huwe, M., Hennigs, A., Oqueka, T., Simon, M., Harbaum, L., Körbelin, J., Schmiedel, S., Schulze Zur Wiesch, J., Addo, M. M., Kluge, S. & Klose, H., 10.2022, In: INFECTION. 50, 5, p. 1391-1397 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Adeno-Associated Virus-Mediated Gene Transfer of Inducible Nitric Oxide Synthase to an Animal Model of Pulmonary Hypertension
Remes, A., Körbelin, J., Arnold, C., Rohwedder, C., Heckmann, M. B., Mairbauerl, H., Frank, D., Korff, T., Frey, N., Trepel, M. & Müller, O. J., 09.2022, In: HUM GENE THER. 33, 17-18, p. 959-967 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The HDL particle composition determines its antitumor activity in pancreatic cancer
Oberle, R., Kührer, K., Österreicher, T., Weber, F., Steinbauer, S., Udonta, F., Wroblewski, M., Ben-Batalla, I., Hassl, I., Körbelin, J., Unseld, M., Jauhiainen, M., Plochberger, B., Röhrl, C., Hengstschläger, M., Loges, S. & Stangl, H., 09.2022, In: LIFE SCI ALLIANCE. 5, 9, e202101317.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Alzheimer's risk factor CD2AP drives defects across the cerebrovascular network
Vandal, M., Gunn, C., Institoris, A., Bourassa, P., Korin, B., Lee, S., Mishra, R., Peringod, G., Hirai, S., Jiang, YL., Belzil, C., Reveret, L., Tremblay, C., Hashem, M., Nicola, W., Körbelin, J., Dunn, J., Braun, A., Bennett, D., Shaw, A., Gordon, G., Calon, FE. & Nguyen, MD., 19.06.2022, In: J CEREBR BLOOD F MET. 42, 1_SUPPL, p. 286-287 2 p.Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
The SARS-CoV-2 main protease induces capillary cell death by cleaving NEMO in brain endothelial cells
Wenzel, J., Lampe, J., Muller-Fielitz, H., Schuster, R., Zille, M., Körbelin, J., Sauve, F., Franz, J., Stadelmann, C., Trottein, F., Glatzel, M., Prevot, V. & Schwaninger, M., 19.06.2022, In: J CEREBR BLOOD F MET. 42, 1_SUPPL, p. 35 1 p.Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
Identification of New AAV9 Engineered Capsids Targeting Mouse and Monkey Brains Through a Directed Evolution Approach in BALB/c Mice
Serena, GG., Luoni, M., Bellinazzi, B., Martin, T., Körbelin, J. & Broccoli, V., 07.06.2022, In: MOL THER. 30, 4, p. 209-210 2 p.Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
AAV-BR1 targets endothelial cells in the retina to reveal their morphological diversity and to deliver Cx43
Ivanova, E., Corona, C., Eleftheriou, C. G., Stout, R. F., Körbelin, J. & Sagdullaev, B. T., 30.03.2022, In: J COMP NEUROL. 530, 8, p. 1302-1317 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Short regulatory DNA sequences to target brain endothelial cells for gene therapy
Graßhoff, H., Müller-Fielitz, H., Dogbevia, G. K., Körbelin, J., Bannach, J., Vahldieck, C. M., Kusche-Vihrog, K., Jöhren, O., Müller, O. J., Nogueiras, R., Prevot, V. & Schwaninger, M., 01.2022, In: J CEREBR BLOOD F MET. 42, 1, p. 104-120 17 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2021
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., Pfefferle, S., Sauve, F., Coêlho, C. F. F., Franz, J., Spiecker, F., Lembrich, B., Binder, S., Feller, N., König, P., Busch, H., Collin, L., Villaseñor, R., Jöhren, O., Altmeppen, H. C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R., Hilgenfeld, R., Glatzel, M., Prevot, V. & Schwaninger, M., 11.2021, In: NAT NEUROSCI. 24, 11, p. 1522-1533 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Vascular Endothelial Cells: Heterogeneity and Targeting Approaches
Hennigs, J. K., Matuszcak, C., Trepel, M. & Körbelin, J., 10.10.2021, In: CELLS-BASEL. 10, 10, p. 2712Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair
Mehina, E. M. F., Taylor, S., Boghozian, R., White, E., Choi, S. E., Cheema, M. S., Korbelin, J. & Brown, C. E., 08.2021, In: SCI ADV. 7, 34Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Inactivation of Adeno-Associated Viral Vectors by Oxidant-Based Disinfectants
Korte, J., Mienert, J., Hennigs, J. K. & Körbelin, J., 07.2021, In: HUM GENE THER. 32, 13-14, p. 771-781 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
Ren, A. A., Snellings, D. A., Su, Y. S., Hong, C. C., Castro, M., Tang, A. T., Detter, M. R., Hobson, N., Girard, R., Romanos, S., Lightle, R., Moore, T., Shenkar, R., Benavides, C., Beaman, M. M., Mueller-Fielitz, H., Chen, M., Mericko, P., Yang, J., Sung, D. C., Lawton, M. T., Ruppert, M., Schwaninger, M., Körbelin, J., Potente, M., Awad, I. A., Marchuk, D. A. & Kahn, M. L., 06.2021, In: NATURE. 594, 7862, p. 271-276 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
Alvarez-Vergara, M. I., Rosales-Nieves, A. E., March-Diaz, R., Rodriguez-Perinan, G., Lara-Ureña, N., Ortega-de San Luis, C., Sanchez-Garcia, M. A., Martin-Bornez, M., Gómez-Gálvez, P., Vicente-Munuera, P., Fernandez-Gomez, B., Marchena, M. A., Bullones-Bolanos, A. S., Davila, J. C., Gonzalez-Martinez, R., Trillo-Contreras, J. L., Sanchez-Hidalgo, A. C., Del Toro, R., Scholl, F. G., Herrera, E., Trepel, M., Körbelin, J., Escudero, L. M., Villadiego, J., Echevarria, M., de Castro, F., Gutierrez, A., Rabano, A., Vitorica, J. & Pascual, A., 25.05.2021, In: NAT COMMUN. 12, 1, 3098.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Identification of New Adeno-Associated Virus 9 (AAV9) Capsid Variants Targeting the BALB/c Mouse Brain through Directed Evolution
Giannelli, SG., Luoni, M., Conti, E., Niro, A., Trepel, M., Körbelin, J. & Broccoli, V., 17.05.2021, In: MOL THER. 29, 4, p. 149-150 2 p.Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice
Park, E. S., Kim, S., Huang, S., Yoo, J. Y., Körbelin, J., Lee, T. J., Kaur, B., Dash, P. K., Chen, P. R. & Kim, E., 05.2021, In: ANN NEUROL. 89, 5, p. 926-941 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A
Nikolakopoulou, A. M., Wang, Y., Ma, Q., Sagare, A. P., Montagne, A., Huuskonen, M. T., Rege, S. V., Kisler, K., Dai, Z., Körbelin, J., Herz, J., Zhao, Z. & Zlokovic, B. V., 05.04.2021, In: J EXP MED. 218, 4, e20202207.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin-dependent vascular remodeling
Chen, D-Y., Sun, N-H., Chen, X., Gong, J-J., Yuan, S-T., Hu, Z-Z., Lu, N-N., Körbelin, J., Fukunaga, K., Liu, Q-H., Lu, Y-M. & Han, F., 15.02.2021, In: J CLIN INVEST. 131, 4, e135296.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension
Hennigs, J. K., Cao, A., Li, C. G., Shi, M., Mienert, J., Miyagawa, K., Körbelin, J., Marciano, D. P., Chen, P-I., Roughley, M., Elliott, M. V., Harper, R. L., Bill, M. A., Chappell, J., Moonen, J-R., Diebold, I., Wang, L., Snyder, M. P. & Rabinovitch, M., 05.02.2021, In: CIRC RES. 128, 3, p. 401-418 18 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2020
Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension
Santisteban, M. M., Ahn, S. J., Lane, D., Faraco, G., Garcia-Bonilla, L., Racchumi, G., Poon, C., Schaeffer, S., Segarra, S. G., Körbelin, J., Anrather, J. & Iadecola, C., 09.2020, In: HYPERTENSION. 76, 3, p. 795-807 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors
Eichhoff, A. M., Börner, K., Albrecht, B., Schäfer, W., Baum, N., Haag, F., Körbelin, J., Trepel, M., Braren, I., Grimm, D., Adriouch, S. & Koch-Nolte, F., 13.12.2019, In: MOL THER-METH CLIN D. 15, p. 211-220 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of NPC2 disease
Hede, E., Heegaard, C., Körbelin, J., Schwaninger, M., Moos, T. & Burkhart, A., 01.11.2019, In: HUM GENE THER. 2019, 30Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
The P2-receptor-mediated Ca2+ signalosome of the human pulmonary endothelium - implications for pulmonary arterial hypertension
Hennigs, J. K., Lüneburg, N., Stage, A., Schmitz, M., Körbelin, J., Harbaum, L., Matuszcak, C., Mienert, J., Bokemeyer, C., Böger, R. H., Kiefmann, R. & Klose, H., 09.2019, In: PURINERG SIGNAL. 15, 3, p. 299-311 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
Yousef, H., Czupalla, C. J., Lee, D., Chen, M. B., Burke, A. N., Zera, K. A., Zandstra, J., Berber, E., Lehallier, B., Mathur, V., Nair, R. V., Bonanno, L. N., Yang, A. C., Peterson, T., Hadeiba, H., Merkel, T., Körbelin, J., Schwaninger, M., Buckwalter, M. S., Quake, S. R., Butcher, E. C. & Wyss-Coray, T., 06.2019, In: NAT MED. 25, 6, p. 988-1000 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4
Tan, C., Lu, N-N., Wang, C-K., Chen, D-Y., Sun, N-H., Lyu, H., Körbelin, J., Shi, W-X., Fukunaga, K., Lu, Y-M. & Han, F., 06.03.2019, In: NEURON. 101, 5, p. 920-937.e13Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Novel Gene Therapy Approaches for Whole Brain Delivery of the Lysosomal Gcase Enzyme for Wide Protection from Alpha-Synuclein Toxic Aggregates
Broccoli, V., Ordozza, G., Bido, S., Valtorta, M., Morabito, G., Körbelin, J., Cacellieri, C. & Giannelli, S., 05.2018, In: MOL THER. 26, 5 Suppl., p. 131-131 278.Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
Assessing the transduction profile of the brain-endothelial directed gene vector AAV-BR1
Körbelin, J., Kleint, M., Dogbevia, G., Ohnmacht, J., Trepel, M. & Schwaninger, M., 02.2018, In: N-S ARCH PHARMACOL. 391, P36.Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
- 2017
Optimization of design and production strategies for novel adeno-associated viral display peptide libraries
Körbelin, J., Hunger, A., Alawi, M., Sieber, T., Binder, M. & Trepel, M., 08.2017, In: GENE THER. 24, 8, p. 470-481Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gene Therapy Decreases Seizures in a Model of Incontinentia Pigmenti
Dogbevia, G. K., Töllner, K., Körbelin, J., Bröer, S., Ridder, D. A., Grasshoff, H., Brandt, C., Wenzel, J., Straub, B. K., Trepel, M., Löscher, W. & Schwaninger, M., 07.2017, In: ANN NEUROL. 82, 1, p. 93-104Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
How to successfully screen random AAV display peptide libraries in vivo
Körbelin, J. & Trepel, M., 06.2017, In: HUM GENE THER METHOD. 28, 3, p. 109-123Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Brain Endothelial-Targeted Gene Therapy in a Mouse Model of Incontinentia Pigmenti
Körbelin, J., Dogbevia, G., Töllner, K., Bröer, S., Ridder, D., Grasshoff, H., Brandt, C., Straub, B., Trepel, M., Löscher, W. & Schwaninger, M., 05.2017, In: MOL THER. 25, 5, p. 256-257Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
Viral vector for the targeted transfer of genes in the brain and spinal cord
Körbelin, J., Michelfelder, S. & Trepel, M., 02.02.2017, IPC No. PCT/EP2015/058123, Priority date 17.04.2014Research output: Patent
- 2016
Vascular-targeted recombinant adeno-associated viral vectors for the treatment of rare diseases
Körbelin, J., Schwaninger, M. & Trepel, M., 10.08.2016, In: Rare Diseases. 4, 1Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases
Körbelin, J., Dogbevia, G., Michelfelder, S., Ridder, D. A., Hunger, A., Wenzel, J., Seismann, H., Lampe, M., Bannach, J., Pasparakis, M., Kleinschmidt, J. A., Schwaninger, M. & Trepel, M., 01.06.2016, In: EMBO MOL MED. 8, 6, p. 609-25Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries
Körbelin, J., Sieber, T., Michelfelder, S., Lunding, L., Spies, E., Hunger, A., Alawi, M., Rapti, K., Indenbirken, D., Müller, O. J., Pasqualini, R., Arap, W., Kleinschmidt, J. A. & Trepel, M., 06.2016, In: MOL THER. 24, 6, p. 1050-61Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genetic manipulation of brain endothelial cells in vivo
Assmann, J. C., Körbelin, J. & Schwaninger, M., 03.2016, In: BBA-MOL BASIS DIS. 1862, 3, p. 381-94Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2015
Erratum for "Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors"
Trepel, M., Körbelin, J., Spies, E., Heckmann, M. B., Hunger, A., Fehse, B., Katus, H. A., Kleinschmidt, J. A., Müller, O. J. & Michelfelder, S., 10.2015, In: GENE THER. 22, 10, p. 840-847Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors
Trepel, M., Körbelin, J., Spies, E., Heckmann, M. B., Hunger, A., Fehse, B., Katus, H. A., Kleinschmidt, J. A., Müller, O. J. & Michelfelder, S., 10.2015, In: GENE THER. 22, 10, p. 840-7 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
Neue Peptide mit Spezifität für die Lunge
Trepel, M., Körbelin, J. & Michelfelder, S., 06.08.2014, IPC No. PCT/EP2014/066892, 12.02.2015, Priority date 09.08.2013, Priority No. DE201310215817Research output: Patent
- 2012
The complete sequence of tobacco mosaic virus isolate Ohio V reveals a high accumulation of silent mutations in all open reading frames
Körbelin, J., Willingmann, P., Adam, G. & Heinze, C., 01.02.2012, In: ARCH VIROL. 157, 2, p. 387-9 3 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo.
Michelfelder, S., Varadi, K., Raupp, C., Hunger, A., Körbelin, J., Pahrmann, C., Schrepfer, S., Müller, O. J., Kleinschmidt, J. A. & Trepel, M., 2011, In: PLOS ONE. 6, 8, p. 23101 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review