Research ExplorerScientific StaffDenise Obrecht-Sturm Publications

Denise Obrecht-Sturm

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Publications

  1. 2024

  2. Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation

    Neyazi, S., Yamazawa, E., Hack, K., Tanaka, S., Nagae, G., Kresbach, C., Umeda, T., Eckhardt, A., Tatsuno, K., Pohl, L., Hana, T., Bockmayr, M., Kim, P., Dorostkar, M. M., Takami, T., Obrecht, D., Takai, K., Suwala, A. K., Komori, T., Godbole, S., Wefers, A. K., Otani, R., Neumann, J. E., Higuchi, F., Schweizer, L., Nakanishi, Y., Monoranu, C-M., Takami, H., Engertsberger, L., Yamada, K., Ruf, V., Nomura, M., Mohme, T., Mukasa, A., Herms, J., Takayanagi, S., Mynarek, M., Matsuura, R., Lamszus, K., Ishii, K., Kluwe, L., Imai, H., von Deimling, A., Koike, T., Benesch, M., Kushihara, Y., Snuderl, M., Nambu, S., Frank, S., Omura, T., Hagel, C., Kugasawa, K., Mautner, V. F., Ichimura, K., Rutkowski, S., Aburatani, H., Saito, N. & Schüller, U., 24.01.2024, In: ACTA NEUROPATHOL. 147, 1, p. 22

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. 2023

  4. Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome

    Kolodziejczak, A. S., Guerrini-Rousseau, L., Planchon, J. M., Ecker, J., Selt, F., Mynarek, M., Obrecht, D., Sill, M., Autry, R. J., Zhao, E., Hirsch, S., Amouyal, E., Dufour, C., Ayrault, O., Torrejon, J., Waszak, S. M., Ramaswamy, V., Pentikainen, V., Demir, H. A., Clifford, S. C., Schwalbe, E. C., Massimi, L., Snuderl, M., Galbraith, K., Karajannis, M. A., Hill, K., Li, B. K., Walsh, M., White, C. L., Redmond, S., Loizos, L., Jakob, M., Kordes, U. R., Schmid, I., Hauer, J., Blattmann, C., Filippidou, M., Piccolo, G., Scheurlen, W., Farrag, A., Grund, K., Sutter, C., Pietsch, T., Frank, S., Schewe, D. M., Malkin, D., Ben-Arush, M., Sehested, A., Wong, T-T., Wu, K-S., Liu, Y-L., Carceller, F., Mueller, S., Stoller, S., Taylor, M. D., Tabori, U., Bouffet, E., Kool, M., Sahm, F., von Deimling, A., Korshunov, A., von Hoff, K., Kratz, C. P., Sturm, D., Jones, D. T. W., Rutkowski, S., van Tilburg, C. M., Witt, O., Bougeard, G., Pajtler, K. W., Pfister, S. M., Bourdeaut, F. & Milde, T., 08.12.2023, In: NEURO-ONCOLOGY. 25, 12, p. 2273-2286 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Risk prediction in early childhood sonic hedgehog medulloblastoma treated with radiation-avoiding chemotherapy

    Tonn, S., Korshunov, A., Obrecht, D., Sill, M., Spohn, M., von Hoff, K., Milde, T., Pietsch, T., Goschzik, T., Bison, B., Juhnke, B-O., Struve, N., Sturm, D., Sahm, F., Bockmayr, M., Friedrich, C., von Bueren, A. O., Gerber, N. U., Benesch, M., Jones, D. T. W., Kool, M., Wefers, A. K., Schüller, U., Pfister, S. M., Rutkowski, S. & Mynarek, M., 03.08.2023, In: NEURO-ONCOLOGY. 25, 8, p. 1518-1529 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Kinder und Jugendliche mit intrakraniellem Ependymom – Empfehlungen der HIT-MED-Studiengruppe der GPOH zur Erstlinientherapie

    Obrecht, D., Mynarek, M., Stickan-Verfürth, M., Bison, B., Schüller, U., Pajtler, K., Hagel, C., Thomale, U-W., Fleischhack, G., Timmermann, B. & Rutkowski, S., 12.05.2023, In: KLIN PADIATR. 235, 3, p. 167-177 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study

    Erker, C., Mynarek, M., Bailey, S., Mazewski, C. M., Baroni, L., Massimino, M., Hukin, J., Aguilera, D., Cappellano, A. M., Ramaswamy, V., Lassaletta, A., Perreault, S., Kline, C. N., Rajagopal, R., Michaiel, G., Zapotocky, M., Santa-Maria Lopez, V., La Madrid, A. M., Cacciotti, C., Sandler, E. S., Hoffman, L. M., Klawinski, D., Khan, S., Salloum, R., Hoppmann, A. L., Larouche, V., Dorris, K., Toledano, H., Gilheeney, S. W., Abdelbaki, M. S., Wilson, B., Tsang, D. S., Knipstein, J., Oren, M. Y., Shah, S., Murray, J. C., Ginn, K. F., Wang, Z. J., Fleischhack, G., Obrecht, D., Tonn, S., Harrod, V. L., Matheson, K., Crooks, B., Strother, D. R., Cohen, K. J., Hansford, J. R., Mueller, S., Margol, A., Gajjar, A., Dhall, G., Finlay, J. L., Northcott, P. A., Rutkowski, S., Clifford, S. C., Robinson, G., Bouffet, E. & Lafay-Cousin, L., 01.04.2023, In: J CLIN ONCOL. 41, 10, p. 1921-1932 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts

    Mynarek, M., Obrecht, D., Sill, M., Sturm, D., Kloth-Stachnau, K., Selt, F., Ecker, J., von Hoff, K., Juhnke, B-O., Goschzik, T., Pietsch, T., Bockmayr, M., Kool, M., von Deimling, A., Witt, O., Schüller, U., Benesch, M., Gerber, N. U., Sahm, F., Jones, D. T. W., Korshunov, A., Pfister, S. M., Rutkowski, S. & Milde, T., 01.2023, In: ACTA NEUROPATHOL. 145, 1, p. 97-112 16 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma

    Ng, C. H., Obrecht, D., Wells, O., Zapotocky, M., Sumerauer, D., Coltin, H., Khuong-Quang, D-A., Eisenstat, D. D., Kinross, K. M., White, C. L., Algar, E. M., Luck, A., Witt, H., Schüller, U., Mynarek, M., Pietsch, T., Gerber, N. U., Benesch, M., Warmuth-Metz, M., Kortmann, R., Bison, B., Taylor, M. D., Rutkowski, S., Pfister, S. M., Jones, D. T., Gottardo, N. G., von Hoff, K., Pajtler, K. W., Ramaswamy, V. & Hansford, J. R., 2023, In: NEURO-ONCOL ADV. 5, 1, p. vdad057

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. 2022

  11. Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas

    Goschzik, T., Mynarek, M., Doerner, E., Schenk, A., Spier, I., Warmuth-Metz, M., Bison, B., Obrecht, D., Struve, N., Kortmann, R-D., Schmid, M., Aretz, S., Rutkowski, S. & Pietsch, T., 12.2022, In: ACTA NEUROPATHOL. 144, 6, p. 1143-1156 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease

    Bockmayr, M., Harnisch, K., Pohl, L. C., Schweizer, L., Mohme, T., Körner, M., Alawi, M., Suwala, A. K., Dorostkar, M. M., Monoranu, C. M., Hasselblatt, M., Wefers, A. K., Capper, D., Hench, J., Frank, S., Richardson, T. E., Tran, I., Liu, E., Snuderl, M., Engertsberger, L., Benesch, M., von Deimling, A., Obrecht, D., Mynarek, M., Rutkowski, S., Glatzel, M., Neumann, J. E. & Schüller, U., 03.10.2022, In: NEURO-ONCOLOGY. 24, 10, p. 1689-1699 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Clinical and molecular characterization of isolated M1 disease in pediatric medulloblastoma: experience from the German HIT-MED studies

    Obrecht, D., Mynarek, M., Hagel, C., Kwiecien, R., Spohn, M., Bockmayr, M., Bison, B., Pfister, S. M., Jones, D. T. W., Sturm, D., von Deimling, A., Sahm, F., von Hoff, K., Juhnke, B-O., Benesch, M., Gerber, N. U., Friedrich, C., von Bueren, A. O., Kortmann, R-D., Schwarz, R., Pietsch, T., Fleischhack, G., Schüller, U. & Rutkowski, S., 03.2022, In: J NEURO-ONCOL. 157, 1, p. 37-48 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. Refining M1 stage in medulloblastoma: criteria for cerebrospinal fluid cytology and implications for improved risk stratification from the HIT-2000 trial

    Hagel, C., Sloman, V., Mynarek, M., Petrasch, K., Obrecht, D., Kühl, J., Deinlein, F., Schmid, R., von Bueren, A. O., Friedrich, C., Juhnke, B. O., Gerber, N. U., Kwiecien, R., Girschick, H., Höller, A., Zapf, A., von Hoff, K. & Rutkowski, S., 03.2022, In: EUR J CANCER. 164, p. 30-38

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma-an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial

    Dietzsch, S., Braesigk, A., Seidel, C., Remmele, J., Kitzing, R., Schlender, T., Mynarek, M., Geismar, D., Jablonska, K., Schwarz, R., Pazos, M., Weber, D. C., Frick, S., Gurtner, K., Matuschek, C., Harrabi, S. B., Glück, A., Lewitzki, V., Dieckmann, K., Benesch, M., Gerber, N. U., Obrecht, D., Rutkowski, S., Timmermann, B. & Kortmann, R-D., 03.2022, In: STRAHLENTHER ONKOL. 198, 3, p. 282-290 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Local and Systemic Therapy of Recurrent Medulloblastomas in Children and Adolescents: Results of the P-HIT-REZ 2005 Study

    Gaab, C., Adolph, J. E., Tippelt, S., Mikasch, R., Obrecht, D., Mynarek, M., Rutkowski, S., Pfister, S. M., Milde, T., Witt, O., Bison, B., Warmuth-Metz, M., Kortmann, R-D., Dietzsch, S., Pietsch, T., Timmermann, B., Sträter, R., Bode, U., Faldum, A., Kwiecien, R. & Fleischhack, G., 18.01.2022, In: CANCERS. 14, 3, 471.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. 2021

  18. Local and Systemic Therapy of Recurrent Ependymoma in Children and Adolescents: Short- and Long-term Results of the E-HIT-REZ 2005 Study

    Adolph, J. E., Fleischhack, G., Mikasch, R., Zeller, J., Warmuth-Metz, M., Bison, B., Mynarek, M., Rutkowski, S., Schüller, U., von Hoff, K., Obrecht, D., Pietsch, T., Pfister, S. M., Pajtler, K. W., Witt, O., Witt, H., Kortmann, R-D., Timmermann, B., Krauß, J., Frühwald, M. C., Faldum, A., Kwiecien, R., Bode, U., Tippelt, S. & German GPOH HIT-Network, 01.06.2021, In: NEURO-ONCOLOGY. 23, 6, p. 1012-1023 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Defining the Spectrum, Treatment and Outcome of Patients With Genetically Confirmed Gorlin Syndrome From the HIT-MED Cohort

    Kloth, K., Obrecht, D., Sturm, D., Pietsch, T., Warmuth-Metz, M., Bison, B., Mynarek, M. & Rutkowski, S., 2021, In: FRONT ONCOL. 11, 756025.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. 2020

  21. Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort

    Mynarek, M., von Hoff, K., Pietsch, T., Ottensmeier, H., Warmuth-Metz, M., Bison, B., Pfister, S., Korshunov, A., Sharma, T., Jaeger, N., Ryzhova, M., Zheludkova, O., Golanov, A., Rushing, E. J., Hasselblatt, M., Koch, A., Schüller, U., von Deimling, A., Sahm, F., Sill, M., Riemenschneider, M. J., Dohmen, H., Monoranu, C. M., Sommer, C., Staszewski, O., Mawrin, C., Schittenhelm, J., Brück, W., Filipski, K., Hartmann, C., Meinhardt, M., Pietschmann, K., Haberler, C., Slavc, I., Gerber, N. U., Grotzer, M., Benesch, M., Schlegel, P. G., Deinlein, F., von Bueren, A. O., Friedrich, C., Juhnke, B-O., Obrecht, D., Fleischhack, G., Kwiecien, R., Faldum, A., Kortmann, R. D., Kool, M. & Rutkowski, S., 20.06.2020, In: J CLIN ONCOL. 38, 18, p. 2028-2040 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Molecular characterization of histopathological ependymoma variants

    Neumann, J. E., Spohn, M., Obrecht, D., Mynarek, M., Thomas, C., Hasselblatt, M., Dorostkar, M. M., Wefers, A. K., Frank, S., Monoranu, C-M., Koch, A., Witt, H., Kool, M., Pajtler, K. W., Rutkowski, S., Glatzel, M. & Schüller, U., 02.2020, In: ACTA NEUROPATHOL. 139, 2, p. 305-318 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. 2017

  24. Effect of patent ductus arteriosus and patent foramen ovale on left ventricular stroke volume measurement by electrical velocimetry in comparison to transthoracic echocardiography in neonates

    Blohm, M. E., Hartwich, J., Obrecht, D., Kersten, J. F. & Singer, D., 06.2017, In: J CLIN MONIT COMPUT. 31, 3, p. 589-598

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. 2015

  26. Long-Term Clinical Relevance of De Novo Donor-Specific Antibodies After Pediatric Liver Transplantation

    Grabhorn, E., Binder, T. M., Obrecht, D., Brinkert, F., Lehnhardt, A., Herden, U., Peine, S., Nashan, B., Ganschow, R. & Briem-Richter, A., 20.02.2015, In: TRANSPLANTATION. 99, 9, p. 1876-1881

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. 2014

  28. Impedance cardiography (electrical velocimetry) and transthoracic echocardiography for non-invasive cardiac output monitoring in pediatric intensive care patients: a prospective single-center observational study

    Blohm, M., Obrecht, D., Hartwich, J., Müller, G., Kersten, J., Weil, J. & Singer, D., 19.11.2014, In: CRIT CARE. 18, 6, p. 603

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. Effect of cerebral circulatory arrest on cerebral near-infrared spectroscopy in pediatric patients

    Blohm, M. E., Obrecht, D., Hartwich, J. & Singer, D., 01.04.2014, In: PEDIATR ANESTH. 24, 4, p. 393-9 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review