PD Dr. med. ID: 31648
Henning Wege
Publications
- 2016
Indikationsstellung für operative Eingriffe und perioperatives Management bei Transplantierten und Immunsupprimierten
Wege, H., Benten, D. & Sterneck, M., 01.12.2016, In: Allgemein- und Viszeralchirurgie up2date. 10, 06, p. 453-464Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
First- and Second-Line Targeted Systemic Therapy in Hepatocellular Carcinoma-An Update on Patient Selection and Response Evaluation
von Felden, J., Schulze, K., Gil-Ibanez, I., Werner, T. & Wege, H., 28.11.2016, In: DIAGNOSTICS. 6, 4, p. E44Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-derived Erythropoietin and Anemia
Rivkin, M., Simerzin, A., Zorde-Khvalevsky, E., Chai, C., Yuval, J. B., Rosenberg, N., Harari-Steinfeld, R., Schneider, R., Amir, G., Condiotti, R., Heikenwalder, M., Weber, A., Schramm, C., Wege, H., Kluwe, J., Galun, E. & Giladi, H., 11.2016, In: GASTROENTEROLOGY. 151, 5, p. 999-1010.e3Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Systemic inflammation in decompensated cirrhosis Characterization and role in acute-on-chronic liver failure
Clària, J., Stauber, R. E., Coenraad, M. J., Moreau, R., Jalan, R., Pavesi, M., Amorós, À., Titos, E., Alcaraz-Quiles, J., Oettl, K., Morales-Ruiz, M., Angeli, P., Domenicali, M., Alessandria, C., Gerbes, A., Wendon, J., Nevens, F., Trebicka, J., Laleman, W., Saliba, F., Welzel, T. M., Albillos, A., Gustot, T., Benten, D., Durand, F., Ginès, P., Bernardi, M., Arroyo, V. & CANONIC Study Investigators of the EASL-CLIF Consortium and the European Foundation for the Study of Chronic Liver Failure (EF-CLIF), 10.2016, In: HEPATOLOGY. 64, 4, p. 1249-64Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response
Heim, D., Gil-Ibanez, I., Herden, J., Parplys, A. C., Borgmann, K., Schmidt-Arras, D., Lohse, A. W., Rose-John, S. & Wege, H., 23.08.2016, In: ONCOTARGET. 7, 34, p. 55639-55648Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Resminostat plus sorafenib as second-line therapy of advanced hepatocellular carcinoma - The SHELTER study
Bitzer, M., Horger, M., Giannini, E. G., Ganten, T. M., Wörns, M. A., Siveke, J. T., Dollinger, M. M., Gerken, G., Scheulen, M. E., Wege, H., Zagonel, V., Cillo, U., Trevisani, F., Santoro, A., Montesarchio, V., Malek, N. P., Holzapfel, J., Herz, T., Ammendola, A. S., Pegoraro, S., Hauns, B., Mais, A., Lauer, U. M., Henning, S. W. & Hentsch, B., 08.2016, In: J HEPATOL. 65, 2, p. 280-8Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling
Wolf, J., Waetzig, G. H., Chalaris, A., Reinheimer, T. M., Wege, H., Rose-John, S. & Garbers, C., 29.07.2016, In: J BIOL CHEM. 291, 31, p. 16186-96Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2015
Aktuelle Therapiekonzepte für lokale Cholangiokarzinome
Seehofer, D., Brunner, TB. & Wege, H., 24.10.2015, In: ONKOLOGE. 10, p. 1054 - 1063Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - a randomized, multidisciplinary, multinational phase III trial
Stein, A., Arnold, D., Bridgewater, J., Goldstein, D., Jensen, L. H., Klümpen, H-J., Lohse, A. W., Nashan, B., Primrose, J., Schrum, S., Shannon, J., Vettorazzi, E. & Wege, H., 31.07.2015, In: BMC CANCER. 15, p. Art. 564Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifies RIPK4 as novel tumor suppressor in human hepatocarcinogenesis
Heim, D., Cornils, K., Schulze, K., Fehse, B., Lohse, A. W., Brümmendorf, T. H. & Wege, H., 2015, In: ONCOGENE. 34, 3, p. 385-393Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver
Ella, E., Heim, D., Stoyanov, E., Harari-Steinfeld, R., Steinfeld, I., Pappo, O., Perlman, T. S., Nachmansson, N., Rivkin, L., Olam, D., Abramovitch, R., Wege, H., Galun, E. & Goldenberg, D., 15.11.2014, In: ONCOTARGET. 5, 21, p. 10318-10331 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure
Jalan, R., Saliba, F., Pavesi, M., Amoros, A., Moreau, R., Ginès, P., Levesque, E., Durand, F., Angeli, P., Caraceni, P., Hopf, C., Alessandria, C., Rodriguez, E., Solis-Muñoz, P., Laleman, W., Trebicka, J., Zeuzem, S., Gustot, T., Mookerjee, R., Elkrief, L., Soriano, G., Cordoba, J., Morando, F., Gerbes, A., Agarwal, B., Samuel, D., Bernardi, M., Arroyo, V. & CANONIC Study Investigators of the EASL–CLIF Consortium, 01.11.2014, In: J HEPATOL. 61, 5, p. 1038-1047 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
TACE plus sorafenib for the treatment of hepatocellular carcinoma: results of the multicenter, phase II SOCRATES trial
Erhardt, A., Kolligs, F., Dollinger, M., Schott, E., Wege, H., Bitzer, M., Gog, C., Lammert, F., Schuchmann, M., Walter, C., Blondin, D., Ohmann, C. & Häussinger, D., 01.11.2014, In: CANCER CHEMOTH PHARM. 74, 5, p. 947-954 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E
Sebode, M., Pischke, S., Lütgehetmann, M., Polywka, S., Quaas, A., Lohse, A. W. & Wege, H., 01.01.2014, In: BMC GASTROENTEROL. 14, 191Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Transduction of fetal mice with a feline lentiviral vector induces liver tumors which exhibit an E2F activation signature
Condiotti, R., Goldenberg, D., Giladi, H., Schnitzer-Perlman, T., Waddington, S. N., Buckley, S. M., Heim, D., Cheung, W., Themis, M., Coutelle, C., Simerzin, A., Osejindu, E., Wege, H., Themis, M. & Galun, E., 01.01.2014, In: MOL THER. 22, 1, p. 59-68 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The diagnosis and treatment of cholangiocarcinoma
Vogel, A., Wege, H., Caca, K., Nashan, B. & Neumann, U., 2014, In: DTSCH ARZTEBL INT. 111, 44, p. 748-54 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Diagnostik und Therapie des hepatozellulären Karzinoms
Greten, T. F., Malek, N. P., Schmidt, S., Arends, J., Bartenstein, P., Bechstein, W., Bernatik, T., Bitzer, M., Chavan, A., Dollinger, M., Domagk, D., Drognitz, O., Düx, M., Farkas, S., Folprecht, G., Galle, P., Geißler, M., Gerken, G., Habermehl, D., Helmberger, T., Herfarth, K., Hoffmann, R. T., Holtmann, M., Huppert, P., Jakobs, T., Keller, M., Klempnauer, J., Kolligs, F., Körber, J., Lang, H., Lehner, F., Lordick, F., Lubienski, A., Manns, M. P., Mahnken, A., Möhler, M., Mönch, C., Neuhaus, P., Niederau, C., Ocker, M., Otto, G., Pereira, P., Pott, G., Riemer, J., Ringe, K., Ritterbusch, U., Rummeny, E., Schirmacher, P., Schlitt, H. J., Schlottmann, K., Schmitz, V., Schuler, A., Schulze-Bergkamen, H., von Schweinitz, D., Seehofer, D., Sitter, H., Straßburg, C. P., Stroszczynski, C., Strobel, D., Tannapfel, A., Trojan, J., van Thiel, I., Vogel, A., Wacker, F., Wedemeyer, H., Wege, H., Weinmann, A., Wittekind, C., Wörmann, B. & Zech, C. J., 01.11.2013, In: Z GASTROENTEROL. 51, 11, p. 1269-326 58 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma
Schulze, K., Gasch, C., Staufer, K., Nashan, B., Lohse, A. W., Pantel, K., Riethdorf, S. & Wege, H., 01.11.2013, In: INT J CANCER. 133, 9, p. 2165-71 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity
Hartjen, P., Höchst, B., Heim, D., von der Kammer, H., Lucke, J., Reinholz, M., Baier, A., Smeets, R., Wege, H., Borowski, P. & Schulze Zur Wiesch, J., 01.09.2013, In: CELL MOL BIOL LETT. 18, 3, p. 447-58 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis
Moreau, R., Jalan, R., Gines, P., Pavesi, M., Angeli, P., Cordoba, J., Durand, F., Gustot, T., Saliba, F., Domenicali, M., Gerbes, A., Wendon, J., Alessandria, C., Laleman, W., Zeuzem, S., Trebicka, J., Bernardi, M., Arroyo, V. & CANONIC Study Investigators of the EASL–CLIF Consortium, 01.06.2013, In: GASTROENTEROLOGY. 144, 7, p. 1426-37, 1437.e1-9Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A needle in a haystack: Identifying biomarkers to personalize systemic therapy in patients with hepatocellular carcinoma
Wege, H., Brümmendorf, T. H. & Gambacorti-Passerini, C., 01.04.2013, In: HEPATOLOGY. 57, 4, p. 1291-3 3 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
- 2012
Systemtherapie des Leberzellkarzinoms
Wege, H. & Arnold, D., 2012, In: ONKOLOGE. 18, 7, p. 602-610 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
Forced activation of β-catenin signaling supports the transformation of hTERT-immortalized human fetal hepatocytes.
Wege, H., Heim, D., Lütgehetmann, M., Dierlamm, J., Lohse, A. W. & Brümmendorf, T. H., 2011, In: MOL CANCER RES. 9, 9, p. 1222-1231 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Functional p53 is required for effective execution of telomerase inhibition in BCR-ABL-positive CML cells.
Brassat, U., Balabanov, S., Bali, D., Dierlamm, J., Balabanov, M., Hartmann, U., Sirma, H., Günes, C., Wege, H., Fehse, B., Gontarewicz, A., Dikomey, E., Borgmann, K. & Brümmendorf, T., 2011, In: EXP HEMATOL. 39, 1, p. 62-66 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT.
Sass, G., Klinger, N., Sirma, H., Hashemolhosseini, S., Hellerbrand, C., Neureiter, D., Wege, H., Ocker, M. & Tiegs, G., 2011, In: INT J ONCOL. 39, 2, p. 433-442 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Rapid quantification of telomerase activity employing an improved real-time telomeric repeat amplification protocol in clinical tissue samples eliminates interference by PCR inhibitors
Schriefer, P., Günes, C. & Wege, H., 2011, In: J Cancer Sci Ther. 3, 8, p. 176-180 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration.
Berna-Thill, M., Berna, M., Kunst, F., Wege, H., Strunnikova, N. V., Gordiyenko, N., Grierson, R., Richard, G. & Csaky, K. G., 2011, In: MOL VIS. 17, p. 85-98Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2010
Telomere und Telomerase in Zellalterung und Karzinogenese
Wege, H. & Brümmendorf, T., 2010, In: BIOspektrum. 3, p. 271-273Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
- 2009
Aurora kinase inhibitor PHA-739358 suppresses growth of hepatocellular carcinoma in vitro and in a xenograft mouse model.
Benten, D., Keller, G., Quaas, A., Schrader, J., Gontarewicz, A., Balabanov, S., Balabanov, M., Wege, H., Moll, J., Lohse, A. W. & Brümmendorf, T., 2009, In: NEOPLASIA. 11, 9, p. 934-944 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hepatic stem and progenitor cells in liver diseases and hepatocarcinogenesis.
Heim, D. & Wege, H., 2009, In: Minerva Gastroenterol Dietol. 55, 2, p. 111-121 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Telomerase-Inhibitoren
Wege, H. & Brümmendorf, T., 2009, Molekulare Therapie in der Hämatologie/Onkologie. Bremen: Uni-Med, 9 p.Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research
Telomeres and telomerase in chronic myeloid leukaemia: impact for pathogenesis, disease progression and targeted therapy.
Keller, G., Brassat, U., Balabanov, M., Heim, D., Wege, H. & Brümmendorf, T., 2009, In: HEMATOL ONCOL. 27, 3, p. 123-129 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2007
Absence of oncogenic transformation despite acquisition of cytogenetic aberrations in long-term cultured telomerase-immortalized human fetal hepatocytes.
Haker, B., Fuchs, S., Dierlamm, J., Brümmendorf, T. & Wege, H., 2007, In: CANCER LETT. 256, 1, p. 120-127 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Regeneration in pig livers by compensatory hyperplasia induces high levels of telomerase activity.
Wege, H., Müller, A., Müller, L., Petri, S., Petersen, J. & Hillert, C., 2007, In: Comp Hepatol. 6, p. 6Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Telomerase activation in liver regeneration and hepatocarcinogenesis: Dr. Jekyll or Mr. Hyde?
Wege, H. & Brümmendorf, T., 2007, In: CURR STEM CELL RES T. 2, 1, p. 31-38 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2004
Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage
Shirahashi, H., Wu, J., Yamamoto, N., Catana, A., Wege, H., Wager, B., Okita, K. & Zern, M. A., 01.01.2004, In: CELL TRANSPLANT. 13, 3, p. 197-211 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2003
Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential
Wege, H., Le, H. T., Chui, M. S., Liu, L., Wu, J., Giri, R., Malhi, H., Sappal, B. S., Kumaran, V., Gupta, S. & Zern, M. A., 01.02.2003, In: GASTROENTEROLOGY. 124, 2, p. 432-44 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity
Wege, H., Chui, M. S., Le, H. T., Tran, J. M. & Zern, M. A., 15.01.2003, In: NUCLEIC ACIDS RES. 31, 2, p. E3-3Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging
Wege, H., Chui, M. S., Le, H. T., Strom, S. C. & Zern, M. A., 01.01.2003, In: CELL TRANSPLANT. 12, 8, p. 897-906 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2001
Cationic lipid polymerization as a novel approach for constructing new DNA delivery agents
Wu, J., Lizarzaburu, M. E., Kurth, M. J., Liu, L., Wege, H., Zern, M. A. & Nantz, M. H., 2001, In: BIOCONJUGATE CHEM. 12, 2, p. 251-7 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review