Research ExplorerScientific StaffChristian Schlein Publications

Dr.med. ID: 6218005

Christian Schlein

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Publications

  1. 2024

  2. Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

    Worthmann, A., Ridder, J., Piel, S. Y. L., Evangelakos, I., Musfeldt, M., Voß, H., O'Farrell, M., Fischer, A. W., Adak, S., Sundd, M., Siffeti, H., Haumann, F., Kloth, K., Bierhals, T., Heine, M., Pertzborn, P., Pauly, M., Scholz, J-J., Kundu, S., Fuh, M. M., Neu, A., Tödter, K., Hempel, M., Knippschild, U., Semenkovich, C. F., Schlüter, H., Heeren, J., Scheja, L., Kubisch, C. & Schlein, C., 02.01.2024, In: NAT COMMUN. 15, 1, p. 45

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. 2022

  4. Clinical and pathological characteristics of familial melanoma with germline TERT promoter variants

    Zaremba, A., Meier, F., Schlein, C., Jansen, P., Lodde, G., Song, M., Kretz, J., Möller, I., Stadtler, N., Livingstone, E., Zimmer, L., Hadaschik, E., Sucker, A., Schadendorf, D. & Griewank, K., 11.2022, In: PIGM CELL MELANOMA R. 35, 6, p. 573-586 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine

    Niemann, B., Haufs-Brusberg, S., Puetz, L., feickert, M., Jaeckstein, M. Y., Hoffmann, A., Zurkovic, J., Heine, M., Trautmann, E-M., Müller, CE., Tönies, A., Schlein, C., Jafari, A., Eltzsching, H. K., Gnad, T., Blüher, M., Krahmer, N., Kovacs, P., Heeren, J. & Pfeifer, A., 08.09.2022, In: NATURE. 609, 7926, p. 361–368 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice

    Evangelakos, I., Kuhl, A., Baguhl, M., Schlein, C., John, C., Rohde, J. K., Heine, M. & Worthmann, A-F., 11.04.2022, In: FRONT CELL DEV BIOL. 10, 10, p. 836741 836741.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. 2021

  8. TFEB-deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality

    Sass, F., Schlein, C., Jaeckstein, M. Y., Pertzborn, P., Schweizer, M., Schinke, T., Ballabio, A., Scheja, L., Heeren, J. & Fischer, A. W., 05.2021, In: MOL METAB. 47, p. 101173

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

    Fischer, A. W., Jaeckstein, M. Y., Gottschling, K., Heine, M., Sass, F., Mangels, N., Schlein, C., Worthmann, A., Bruns, O. T., Yuan, Y., Zhu, H., Chen, O., Ittrich, H., Nilsson, S. K., Stefanicka, P., Ukropec, J., Balaz, M., Dong, H., Sun, W., Reimer, R., Scheja, L. & Heeren, J., 02.03.2021, In: CELL METAB. 33, 3, p. 547-564.e7

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

    Schlein, C., Fischer, A. W., Sass, F., Worthmann, A., Tödter, K., Jaeckstein, M. Y., Behrens, J., Lynes, M. D., Kiebish, M. A., Narain, N. R., Bussberg, V., Jespersen, N. Z., Nielsen, S., Scheele, C., Schweizer, M., Braren, I., Bartelt, A., Tseng, Y-H., Heeren, J. & Scheja, L., 12.01.2021, In: CELL REP. 34, 2, p. 108624

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. 2020

  12. Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice

    Fischer, A. W., Behrens, J., Sass, F., Schlein, C., Heine, M., Pertzborn, P., Scheja, L. & Heeren, J., 11.2020, In: J LIPID RES. 61, 11, p. 1377-1389 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue's Competence for Cold-Induced Thermogenic Recruitment

    Fischer, A. W., de Jong, J. M. A., Sass, F., Schlein, C., Heeren, J. & Petrovic, N., 2020, In: FRONT ENDOCRINOL. 11, p. 568682

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. 2019

  15. PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles

    Fischer, A. W., Albers, K., Schlein, C., Sass, F., Krott, L. M., Schmale, H., Gordts, P. L. S. M., Scheja, L. & Heeren, J., 01.06.2019, In: BBA-MOL BASIS DIS. 1865, 6, p. 1592-1603 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Intact innervation is essential for diet-induced recruitment of brown adipose tissue

    Fischer, A. W., Schlein, C., Cannon, B., Heeren, J. & Nedergaard, J., 01.03.2019, In: AM J PHYSIOL-ENDOC M. 316, 3, p. E487-E503

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression

    Worthmann, A., Schlein, C., Berbée, J. F. P., Rensen, P. C. N., Heeren, J. & Bartelt, A., 23.02.2019, In: NUTRIENTS. 11, 2

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. 2018

  19. Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

    Heine, M., Fischer, A. W., Schlein, C., Jung, C., Straub, L. G., Gottschling, K., Mangels, N., Yuan, Y., Nilsson, S. K., Liebscher, G., Chen, O., Schreiber, R., Zechner, R., Scheja, L. & Heeren, J., 02.10.2018, In: CELL METAB. 28, 4, p. 644-655.e4

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors

    Kraef, C., Schlein, C., Hiller, J., Westhölter, D., Denzer, U., Horvatits, T., Peine, S., Lohse, A. W., Lütgehetmann, M., Polywka, S. & Pischke, S., 08.2018, In: J CLIN VIROL. 105, p. 26-30 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. FoxO transcription factors are required for hepatic HDL-cholesterol clearance

    Lee, S. X., Heine, M., Schlein, C., Ramakrishnan, R., Liu, J., Belnavis, G., Haimi, I., Fischer, A. W., Ginsberg, H., Heeren, J., Rinninger, F. & Haeusler, R. A., 02.04.2018, In: J CLIN INVEST. 128, 4, p. 1615-1626 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

    Bartelt, A., Widenmaier, S. B., Schlein, C., Johann, K., Goncalves, R. L. S., Eguchi, K., Fischer, A. W., Parlakgül, G., Snyder, N. A., Nguyen, T. B., Bruns, O. T., Franke, D., Bawendi, M. G., Lynes, M. D., Leiria, L. O., Tseng, Y-H., Inouye, K. E., Arruda, A. P. & Hotamisligil, G. S., 03.2018, In: NAT MED. 24, 3, p. 292-303 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. 2017

  24. Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

    Worthmann, A., John, C., Rühlemann, M. C., Baguhl, M., Heinsen, F-A., Schaltenberg, N., Heine, M., Schlein, C., Evangelakos, I., Mineo, C., Fischer, M., Dandri, M., Kremoser, C., Scheja, L., Franke, A., Shaul, P. W. & Heeren, J., 07.2017, In: NAT MED. 23, 7, p. 839-849 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

    Bartelt, A., John, C., Schaltenberg, N., Berbée, J. F. P., Worthmann, A., Cherradi, M. L., Schlein, C., Piepenburg, J., Boon, M. R., Rinninger, F., Heine, M., Toedter, K., Niemeier, A., Nilsson, S. K., Fischer, M., Wijers, S. L., van Marken Lichtenbelt, W. D., Scheja, L., Rensen, P. C. N. & Heeren, J., 19.04.2017, In: NAT COMMUN. 8, p. Art. 15010

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. 2016

  27. Implications of thermogenic adipose tissues for metabolic health

    Schlein, C. & Heeren, J., 08.2016, In: BEST PRACT RES CL EN. 30, 4, p. 487-496 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

    Schlein, C., Talukdar, S., Heine, M., Fischer, A. W., Krott, L. M., Nilsson, S. K., Brenner, M. B., Heeren, J. & Scheja, L., 08.03.2016, In: CELL METAB. 23, 3, p. 441-53 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

    Chen, Y., Buyel, J. J., Hanssen, M. J. W., Siegel, F., Pan, R., Naumann, J., Schell, M., van der Lans, A., Schlein, C., Froehlich, H., Heeren, J., Virtanen, K. A., van Marken Lichtenbelt, W. & Pfeifer, A., 2016, In: NAT COMMUN. 7, p. 11420

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. 2015

  31. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

    Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., Jung, C., Vazirpanah, N., Brouwers, L. P. J., Gordts, P. L. S. M., Esko, J. D., Hiemstra, P. S., Havekes, L. M., Scheja, L., Heeren, J. & Rensen, P. C. N., 2015, In: NAT COMMUN. 6, p. 6356

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity

    Wagner, T., Bartelt, A., Schlein, C. & Heeren, J., 2015, In: PLOS ONE. 10, 12, e0145102.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. 2014

  34. Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant

    Albers, K., Schlein, C., Wenner, K., Lohse, P., Bartelt, A., Heeren, J., Santer, R. & Merkel, M., 01.03.2014, In: ATHEROSCLEROSIS. 233, 1, p. 97-103 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review