Till Holsten
Publications
- 2023
Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics
Johann, P. D., Altendorf, L., Efremova, E-M., Holsten, T., Steinbügl, M., Nemes, K., Eckhardt, A., Kresbach, C., Bockmayr, M., Koch, A., Haberler, C., Antonelli, M., DeSisto, J., Schuhmann, M. U., Hauser, P., Siebert, R., Bens, S., Kool, M., Green, A. L., Hasselblatt, M., Frühwald, M. C. & Schüller, U., 09.2023, In: ACTA NEUROPATHOL. 146, 3, p. 527-541 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2022
ALK inhibition as a salvage therapy for a relapsed unclassifiable sarcomatous CNS tumor with EML4/ALK fusion in an infant
Holsten, T., Bronsema, A., Sturm, D., Sahm, F., Rutkowski, S., Ulrich, S., Wößmann, W. & Kordes, U. R., 08.2022, In: PEDIATR BLOOD CANCER. 69, 8, e29594.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors
Graf, M., Interlandi, M., Moreno, N., Holdhof, D., Göbel, C., Melcher, V., Mertins, J., Albert, T. K., Kastrati, D., Alfert, A., Holsten, T., de Faria, F., Meisterernst, M., Rossig, C., Warmuth-Metz, M., Nowak, J., Meyer Zu Hörste, G., Mayère, C., Nef, S., Johann, P., Frühwald, M. C., Dugas, M., Schüller, U. & Kerl, K., 22.03.2022, In: NAT COMMUN. 13, 1, 1544.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2021
Detailed Clinical and Histopathological Description of 8 Cases of Molecularly Defined CNS Neuroblastomas
Holsten, T., Lubieniecki, F., Spohn, M., Mynarek, M., Bison, B., Löbel, U., Rutkowski, S. & Schüller, U., 01.01.2021, In: J NEUROPATH EXP NEUR. 80, 1, p. 52-59 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Ependymoma relapse goes along with a relatively stable epigenome, but a severely altered tumor morphology
Yang, D., Holsten, T., Börnigen, D., Frank, S., Mawrin, C., Glatzel, M. & Schüller, U., 01.2021, In: BRAIN PATHOL. 31, 1, p. 33-44 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2020
Pik3ca mutations significantly enhance the growth of Shh medulloblastoma and lead to metastatic tumour growth in a novel mouse model
Niesen, J., Ohli, J., Sedlacik, J., Dührsen, L., Hellwig, M., Spohn, M., Holsten, T. & Schüller, U., 01.05.2020, In: CANCER LETT. 477, p. 10-18 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Germline variants in SMARCB1 and other members of the BAF chromatin-remodeling complex across human disease entities: a meta-analysis
Holsten, T., Bens, S., Oyen, F., Nemes, K., Hasselblatt, M., Kordes, U., Siebert, R., Frühwald, M. C., Schneppenheim, R. & Schüller, U., 08.2018, In: EUR J HUM GENET. 26, 8, p. 1083-1093 11 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Group 3 medulloblastoma in a patient with a GYS2 germline mutation and glycogen storage disease 0a
Holsten, T., Tsiakas, K., Kordes, U., Bison, B., Pietsch, T., Rutkowski, S., Santer, R. & Schüller, U., 03.2018, In: CHILD NERV SYST. 34, 3, p. 581-584 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors
Moreno, N., Holsten, T., Mertins, J., Zoghbi, A., Johann, P-D., Kool, M., Meisterernst, M. & Kerl, K., 10.2017, In: ONCOTARGET. 8, 49, p. 84986-84995Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S
Holsten, T., Schuster, T., Grabhorn, E., Hero, B. & Frühwald, M. C., 02.2017, In: PEDIATR HEMAT ONCOL. 34, 1, p. 17-23 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1
Kerl, K., Moreno, N., Holsten, T., Ahlfeld, J., Mertins, J., Hotfilder, M., Kool, M., Bartelheim, K., Schleicher, S., Handgretinger, R., Schüller, U., Meisterernst, M. & Frühwald, M. C., 15.08.2014, In: INT J CANCER. 135, 4, p. 989-95 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Rhabdoid tumors: clinical approaches and molecular targets for innovative therapy
Kerl, K., Holsten, T. & Frühwald, M. C., 10.2013, In: PEDIATR HEMAT ONCOL. 30, 7, p. 587-604 18 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research