Dr.med. ID: 55525
Lasse Dührsen
Publications
- 2024
Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
Drexler, R., Khatri, R., Schüller, U., Eckhardt, A., Ryba, A., Sauvigny, T., Dührsen, L., Mohme, M., Ricklefs, T., Bode, H., Hausmann, F., Huber, T. B., Bonn, S., Voß, H., Neumann, J. E., Silverbush, D., Hovestadt, V., Suvà, M. L., Lamszus, K., Gempt, J., Westphal, M., Heiland, D. H., Hänzelmann, S. & Ricklefs, F. L., 20.01.2024, In: ACTA NEUROPATHOL. 147, 1, p. 21Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2023
Machine learning based outcome prediction of microsurgically treated unruptured intracranial aneurysms
Stroh, N., Stefanits, H., Maletzky, A., Kaltenleithner, S., Thumfart, S., Giretzlehner, M., Drexler, R., Ricklefs, F. L., Dührsen, L., Aspalter, S., Rauch, P., Gruber, A. & Gmeiner, M., 19.12.2023, In: SCI REP-UK. 13, 1, p. 22641Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Epigenetic profiling reveals a strong association between lack of 5-ALA fluorescence and EGFR amplification in IDH-wildtype glioblastoma
Drexler, R., Sauvigny, T., Schüller, U., Eckhardt, A., Maire, C. L., Khatri, R., Hausmann, F., Hänzelmann, S., Huber, T. B., Bonn, S., Bode, H., Lamszus, K., Westphal, M., Dührsen, L. & Ricklefs, F. L., 10.2023, In: NEURO-ONCOL PRACT. 10, 5, p. 462-471 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Histogram-Based Analysis of Low- and High-Grade Glioma and Its Surrounding Edema Using Arterial Spin Labeling Magnetic Resonance Imaging
Lindner, T., Dührsen, L., Kyselyova, A., Entelmann, W., Hau, L. & Fiehler, J., 21.09.2023, In: APPL SCI-BASEL. 13, 19, 10581.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability
Drexler, R., Khatri, R., Sauvigny, T., Mohme, M., Maire, C. L., Ryba, A., Zghaibeh, Y., Dührsen, L., Salviano-Silva, A., Lamszus, K., Westphal, M., Gempt, J., Wefers, A. K., Neumann, J., Bode, H., Hausmann, F., Huber, T. B., Bonn, S., Jütten, K., Delev, D., Weber, K. J., Harter, P. N., Onken, J., Vajkoczy, P., Capper, D., Wiestler, B., Weller, M., Snijder, B., Buck, A., Weiss, T., Keough, M. B., Ni, L., Monje, M., Silverbush, D., Hovestadt, V., Suvà, M. L., Krishna, S., Hervey-Jumper, S. L., Schüller, U., Heiland, D. H., Hänzelmann, S. & Ricklefs, F. L., 07.08.2023, In: bioRxiv.Research output: SCORING: Contribution to journal › Preprint › Research
Association of the classification of intraoperative adverse events (ClassIntra) with complications and neurological outcome after neurosurgical procedures: a prospective cohort study
Drexler, R., Ricklefs, F. L., Pantel, T., Göttsche, J., Nitzschke, R., Zöllner, C., Westphal, M. & Dührsen, L., 08.2023, In: ACTA NEUROCHIR. 165, 8, p. 2015-2027 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment
Träger, M., Schweizer, L., Pérez, E., Schmid, S., Hain, E. G., Dittmayer, C., Onken, J., Fukuoka, K., Ichimura, K., Schüller, U., Dührsen, L., Müther, M., Paulus, W., Thomas, C., Gutt-Will, M., Schucht, P., Maragkou, T., Schittenhelm, J., Eckert, F., Niyazi, M., Fleischmann, D. F., Dorostkar, M. M., Feyer, P., May, S-A., Moskopp, D., Badakhshi, H., Radke, C., Walter, J., Ehret, F., Capper, D. & Kaul, D., 06.07.2023, In: NEURO-ONCOLOGY. 25, 7, p. 1286-1298 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Targeted anticonvulsive treatment of IDH-wildtype glioblastoma based on DNA methylation subclasses
Drexler, R., Göttsche, J., Sauvigny, T., Schüller, U., Khatri, R., Hausmann, F., Hänzelmann, S., Huber, T. B., Bonn, S., Heiland, D. H., Delev, D., Venkataramani, V., Winkler, F., Weller, J., Zeyen, T., Herrlinger, U., Gempt, J., Ricklefs, F. L. & Dührsen, L., 04.05.2023, In: NEURO-ONCOLOGY. 25, 5, p. 1006-1008 3 p.Research output: SCORING: Contribution to journal › Letter › Research › peer-review
Multiple craniotomies in a single surgery - the resection of scattered brain metastases
Bschorer, M., Ricklefs, F. L., Sauvigny, T., Westphal, M. & Dührsen, L., 15.03.2023, In: NEUROSURG REV. 46, 1, p. 70Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impact of the SARS-CoV-2 pandemic on the survival of patients with high-grade glioma and best practice recommendations
Vogel, M. M. E., Wagner, A., Gempt, J., Krenzlin, H., Zeyen, T., Drexler, R., Voss, M., Nettekoven, C., Abboud, T., Mielke, D., Rohde, V., Timmer, M., Goldbrunner, R., Steinbach, J. P., Dührsen, L., Westphal, M., Herrlinger, U., Ringel, F., Meyer, B. & Combs, S. E., 16.02.2023, In: SCI REP-UK. 13, 1, p. 2766Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
DNA methylation subclasses predict the benefit from gross total tumor resection in IDH-wildtype glioblastoma patients
Drexler, R., Schüller, U., Eckhardt, A., Filipski, K., Hartung, T. I., Harter, P. N., Divé, I., Forster, M-T., Czabanka, M., Jelgersma, C., Onken, J., Vajkoczy, P., Capper, D., Siewert, C., Sauvigny, T., Lamszus, K., Westphal, M., Dührsen, L. & Ricklefs, F. L., 14.02.2023, In: NEURO-ONCOLOGY. 25, 2, p. 315-325 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Corticosteroid-Dependent Leukocytosis Masks the Predictive Potential of White Blood Cells for Delayed Cerebral Ischemia and Ventriculoperitoneal Shunt Dependency in Aneurysmatic Subarachnoid Hemorrhage
Piffko, A., Ricklefs, F. L., Schweingruber, N., Sauvigny, T., Mader, M. M-D., Mohme, M., Dührsen, L., Westphal, M., Regelsberger, J., Schmidt, N. O. & Czorlich, P., 28.01.2023, In: J CLIN MED. 12, 3, 1006.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Brain Abscess Due to Streptococcus Anginosus After Professional Dental Cleaning
Brehm, T. T., Flottmann, F. & Dührsen, L., 09.01.2023, In: DTSCH ARZTEBL INT. 120, 1-2, p. 13Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
- 2022
Diagnostic potential of extracellular vesicles in meningioma patients
Ricklefs, F. L., Maire, C. L., Wollmann, K., Dührsen, L., Fita, K. D., Sahm, F., Herold-Mende, C., von Deimling, A., Kolbe, K., Holz, M., Bergmann, L., Fuh, M. M., Schlüter, H., Alawi, M., Reimer, R., Sven, P., Glatzel, M., Westphal, M. & Lamszus, K., 01.12.2022, In: NEURO-ONCOLOGY. 24, 12, p. 2078-2090 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Diffusion tensor imaging changes in patients with glioma-associated seizures
Mader, M. M-D., Deuter, D., Sauvigny, T., Borchert, P., Faizy, T. D., Bester, M., Westphal, M., Rosengarth, K., Schmidt, N. O., Sedlacik, J. & Dührsen, L., 07.11.2022, In: J NEURO-ONCOL. 160, 2, p. 311-320 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
DNA Methylation subclass Receptor Tyrosine Kinase II (RTK II) is predictive for seizure development in glioblastoma patients
Ricklefs, F. L., Drexler, R., Wollmann, K., Eckhardt, A., Heiland, D. H., Sauvigny, T., Maire, C., Lamszus, K., Westphal, M., Schüller, U. & Dührsen, L., 02.11.2022, In: NEURO-ONCOLOGY. 24, 11, p. 1886-1897 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Experiences with a 3D4K digital exoscope system (ORBEYE) in a wide range of neurosurgical procedures
Göttsche, J., Piffko, A., Pantel, T. F., Westphal, M., Flitsch, J., Ricklefs, F. L., Regelsberger, J. & Dührsen, L., 11.2022, In: J NEUROL SURG PART A. 83, 6, p. 596-601 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas
Ricklefs, F. L., Fita, K., Mohme, M., Mawrin, C., Rahmanzade, R., Sahm, F., Dührsen, L., Göbel, C., Lamszus, K., Westphal, M., Schüller, U. & Eicker, S-O., 11.2022, In: ACTA NEUROPATHOL. 144, 5, p. 1057-1059 3 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Clinical determinants impacting overall survival of patients with operable brain metastases from non-small cell lung cancer
Piffko, A., Asey, B., Dührsen, L., Ristow, I., Salamon, J., Wikman, H., Maire, C. L., Lamszus, K., Westphal, M., Sauvigny, T. & Mohme, M., 20.10.2022, In: FRONT ONCOL. 12, 951805.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Single-Center Experience Using a 3D4K Digital Operating Scope System for Aneurysm Surgery
Pantel, T., Drexler, R., Göttsche, J., Piffko, A., Westphal, M., Regelsberger, J. & Dührsen, L., 01.06.2022, In: OPER NEUROSURG. 22, 6, p. 433-439 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Measurements of Functional Network Connectivity Using Resting State Arterial Spin Labeling During Neurosurgery
Lindner, T., Ahmeti, H., Helle, M., Jansen, O., Fiehler, J., Dührsen, L., Synowitz, M., Kesari, S. & Ulmer, S., 01.2022, In: WORLD NEUROSURG. 157, p. 152-158 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Aneurysm Location Affects Clinical Course and Mortality in Patients With Subarachnoid Hemorrhage
Göttsche, J., Piffko, A., Pantel, T. F., Westphal, M., Dührsen, L., Czorlich, P. & Sauvigny, T., 2022, In: FRONT NEUROL. 13, 846066.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2021
Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry
Drexler, R., Ben-Haim, S., Bien, C. G., Borger, V., Cardinale, F., Carpentier, A., Cendes, F., Chandra, S., Clusmann, H., Colon, A., de Curtis, M., Delev, D., Didato, G., Dührsen, L., Farah, J. O., Guenot, M., Ghatan, S., Haegelen, C., Hamer, H., Hauptmann, J. S., Jeffree, R. L., Kalbhenn, T., Kegele, J., Krayenbühl, N., Lang, J., Mathon, B., Naros, G., Onken, J., Panov, F., Raftopoulos, C., Ricklefs, F. L., Rijkers, K., Rizzi, M., Rössler, K., Schijns, O., Schneider, U. C., Spyrantis, A., Strzelczyk, A., Stodieck, S., Tripathi, M., Vadera, S., Alonso-Vanegas, M. A., Vaz, J. G. R., Wellmer, J., Wehner, T., Westphal, M. & Sauvigny, T., 13.12.2021, In: FRONT NEUROL. 12, 782666.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Imaging-Based Outcome Prediction of Acute Intracerebral Hemorrhage
Nawabi, J., Kniep, H., Elsayed, S., Friedrich, C., Sporns, P., Rusche, T., Böhmer, M., Morotti, A., Schlunk, F., Dührsen, L., Broocks, G., Schön, G., Quandt, F., Thomalla, G., Fiehler, J. & Hanning, U., 12.2021, In: TRANSL STROKE RES. 12, 6, p. 958-967 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification
Maire, C. L., Fuh, M. M., Kaulich, K., Fita, K. D., Stevic, I., Heiland, D. H., Welsh, J. A., Jones, J. C., Görgens, A., Ricklefs, T., Dührsen, L., Sauvigny, T., Joosse, S. A., Reifenberger, G., Pantel, K., Glatzel, M., Miklosi, A. G., Felce, J. H., Caselli, M., Pereno, V., Reimer, R., Schlüter, H., Westphal, M., Schüller, U., Lamszus, K. & Ricklefs, F. L., 01.07.2021, In: NEURO-ONCOLOGY. 23, 7, p. 1087-1099 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Resective epilepsy surgery in patients aged 50years and older - a retrospective study regarding seizure outcome, memory performance, and psychopathology
Hebel, J. M., Heerwig, C., Möller, H., Sauvigny, T., Martens, T., Dührsen, L., Stodieck, S. R. G., Brückner, K. & Lanz, M., 05.2021, In: EPILEPSY BEHAV. 118, 107933.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2020
Glioma escape signature and clonal development under immune pressure
Maire, C. L., Mohme, M., Bockmayr, M., Fita, K. D., Riecken, K., Börnigen, D., Alawi, M., Failla, A. V., Kolbe, K., Zapf, S., Holz, M., Neumann, K., Dührsen, L., Lange, T., Fehse, B., Westphal, M. & Lamszus, K., 01.10.2020, In: J CLIN INVEST. 130, 10, p. 5257-5271 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Decision-making in temporal lobe epilepsy surgery based on invasive stereo-electroencephalography (sEEG)
Dührsen, L., Sauvigny, T., Ricklefs, F. L., Hamel, W., Koeppen, J. A., Hebel, J. M., Lanz, M. & Martens, T., 10.2020, In: NEUROSURG REV. 43, 5, p. 1403-1408 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Local intracerebral immunomodulation using interleukin-expressing mesenchymal stem cells in glioblastoma
Mohme, M., Maire, C. L., Geumann, U., Schliffke, S., Dührsen, L., Fita, K. D., Akyüz, N., Binder, M., Westphal, M., Guenther, C., Lamszus, K., Hermann, F. G. & Schmidt, N. O., 01.06.2020, In: CLIN CANCER RES. 26, 11, p. 2626-2639 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pik3ca mutations significantly enhance the growth of Shh medulloblastoma and lead to metastatic tumour growth in a novel mouse model
Niesen, J., Ohli, J., Sedlacik, J., Dührsen, L., Hellwig, M., Spohn, M., Holsten, T. & Schüller, U., 01.05.2020, In: CANCER LETT. 477, p. 10-18 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Inter- and Intrarater Agreement of Spot Sign and Noncontrast CT Markers for Early Intracerebral Hemorrhage Expansion
Nawabi, J., Elsayed, S., Kniep, H., Sporns, P., Schlunk, F., McDonough, R., Broocks, G., Dührsen, L., Schön, G., Götz, T., Fiehler, J. & Hanning, U., 04.04.2020, In: J CLIN MED. 9, 4Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Initial pupil status is a strong predictor for in-hospital mortality after aneurysmal subarachnoid hemorrhage
Mader, M. M., Piffko, A., Dengler, N. F., Ricklefs, F. L., Dührsen, L., Schmidt, N. O., Regelsberger, J., Westphal, M., Wolf, S. & Czorlich, P., 16.03.2020, In: SCI REP-UK. 10, 1, p. 4764Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
Ricklefs, F. L., Maire, C. L., Matschke, J., Dührsen, L., Sauvigny, T., Holz, M., Kolbe, K., Peine, S., Herold-Mende, C., Carter, B., Chiocca, E. A., Lawler, S. E., Westphal, M. & Lamszus, K., 12.03.2020, In: INT J MOL SCI. 21, 6Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma
Dührsen, L., Hartfuß, S., Hirsch, D., Geiger, S., Maire, C. L., Sedlacik, J., Guenther, C., Westphal, M., Lamszus, K., Hermann, F. G. & Schmidt, N. O., 22.10.2019, In: ONCOTARGET. 10, 58, p. 6049-6061 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Rate and risk factors for a hyperactivity delirium in patients with aneurysmal subarachnoid haemorrhage
Sauvigny, T., Mohme, M., Grensemann, J., Dührsen, L., Regelsberger, J., Kluge, S., Schmidt, N. O., Westphal, M. & Czorlich, P., 06.2019, In: NEUROSURG REV. 42, 2, p. 481-488 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling
Ricklefs, F. L., Fritzsche, F., Winkler, B., Meissner, B., Dührsen, L., Westphal, M., Rutkowski, S., Martens, T. & Schüller, U., 06.2019, In: CHILD NERV SYST. 35, 6, p. 1029-1033 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Seizures as presenting symptom in patients with glioblastoma
Dührsen, L., Sauvigny, T., Ricklefs, F. L., Mende, K-C., Schaper, M., Matschke, J., Goebell, E., Westphal, M. & Martens, T., 01.2019, In: EPILEPSIA. 60, 1, p. 149-154 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours
Ricklefs, F. L., Maire, C. L., Reimer, R., Dührsen, L., Kolbe, K., Holz, M., Schneider, E., Rissiek, A., Babayan, A., Hille, C., Pantel, K., Krasemann, S., Glatzel, M., Heiland, D. H., Flitsch, J., Martens, T., Schmidt, N. O., Peine, S., Breakefield, X. O., Lawler, S., Chiocca, E. A., Fehse, B., Giebel, B., Görgens, A., Westphal, M. & Lamszus, K., 2019, In: J EXTRACELL VESICLES. 8, 1, p. 1588555Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Impact of focal cortical dysplasia Type IIIa on seizure outcome following anterior mesial temporal lobe resection for the treatment of epilepsy
Dührsen, L., Sauvigny, T., House, P. M., Stodieck, S., Holst, B., Matschke, J., Schön, G., Westphal, M. & Martens, T., 06.2018, In: J NEUROSURG. 128, 6, p. 1668-1673 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Basilar impression as complication of Grisel's syndrome
Dührsen, L., Abboud, T., Viezens, L., Eicker, S. O. & Dreimann, M., 01.2018, In: CLIN CASE REP. 6, 1, p. 185-188 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
A 55-Year-Old Woman with Year-Long Headache and Dizziness
Dührsen, L., Matschke, J. & Westphal, M., 2017, In: BRAIN PATHOL. 27, 1, p. 111-112Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2016
Neuropsychological performance and seizure control after subsequent anteromesial temporal lobe resection following selective amygdalohippocampectomy
Sauvigny, T., Brückner, K., Dührsen, L., Heese, O., Westphal, M., Stodieck, S. R. G. & Martens, T., 11.2016, In: EPILEPSIA. 57, 11, p. 1789-1797 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A novel threshold criterion in transcranial motor evoked potentials during surgery for gliomas close to the motor pathway
Abboud, T., Schaper, M., Dührsen, L., Schwarz, C., Schmidt, N. O., Westphal, M. & Martens, T., 22.01.2016, In: J NEUROSURG. 125, 4, p. 795-802 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Meninigiomas of the Craniocervical Junction - A Distinctive Subgroup of Meningiomas
Dührsen, L., Emami, P., Matschke, J., Abboud, T., Westphal, M. & Regelsberger, J., 2016, In: PLOS ONE. 11, 4, p. e0153405Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2015
Serum levels of nimodipine in enteral and parenteral administration in patients with aneurysmal subarachnoid hemorrhage
Abboud, T., Andresen-Streichert, H., Koeppen, J., Czorlich, P., Dührsen, L., Stenzig, J., Westphal, M. & Regelsberger, J., 05.2015, In: ACTA NEUROCHIR. 157, 5, p. 763-767Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Minimally invasive approach for small ventrally located intradural lesions of the craniovertebral junction
Eicker, S. O., Mende, C., Dührsen, L. & Schmidt, N. O., 01.04.2015, In: NEUROSURG FOCUS. 38, 4, p. E10Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain
Dührsen, L., Simons, S. H. P., Dzietko, M., Genz, K., Bendix, I., Boos, V., Sifringer, M., Tibboel, D. & Felderhoff-Mueser, U., 01.01.2013, In: NEONATOLOGY. 103, 1, p. 35-43 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review