Dr.med. ID: 33796
Kai Lehmberg
Group leader
Publications
- 2017
Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients
Chiang, S. C. C., Wood, S. M., Tesi, B., Akar, H. H., Al-Herz, W., Ammann, S., Belen, F. B., Caliskan, U., Kaya, Z., Lehmberg, K., Patiroglu, T., Tokgoz, H., Ünüvar, A., Introne, W. J., Henter, J-I., Nordenskjöld, M., Ljunggren, H-G., Meeths, M., Ehl, S., Krzewski, K. & Bryceson, Y. T., 2017, In: FRONT IMMUNOL. 8, p. 426Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2016
EZH2 mutation in an adolescent with Weaver syndrome developing acute myeloid leukemia and secondary hemophagocytic lymphohistiocytosis
Usemann, J., Ernst, T., Schäfer, V., Lehmberg, K. & Seeger, K., 05.2016, In: AM J MED GENET A. 170, 5, p. 1274-7 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis
Hartz, B., Marsh, R., Rao, K., Henter, J-I., Jordan, M., Filipovich, L., Bader, P., Beier, R., Burkhardt, B., Meisel, R., Schulz, A., Winkler, B., Albert, M. H., Greil, J., Karasu, G., Woessmann, W., Corbaciologlu, S., Gruhn, B., Holter, W., Kühl, J-S., Lang, P., Seidel, M. G., Veys, P., Löfstedt, A., Ammann, S., Ehl, S., Janka, G., Müller, I. & Lehmberg, K., 20.04.2016, In: BLOOD. 127, 25, p. 3281-90Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative
Ravelli, A., Minoia, F., Davì, S., Horne, A., Bovis, F., Pistorio, A., Aricò, M., Avcin, T., Behrens, E. M., De Benedetti, F., Filipovic, L., Grom, A. A., Henter, J-I., Ilowite, N. T., Jordan, M. B., Khubchandani, R., Kitoh, T., Lehmberg, K., Lovell, D. J., Miettunen, P., Nichols, K. E., Ozen, S., Pachlopnik Schmid, J., Ramanan, A. V., Russo, R., Schneider, R., Sterba, G., Uziel, Y., Wallace, C., Wouters, C., Wulffraat, N., Demirkaya, E., Brunner, H. I., Martini, A., Ruperto, N., Cron, R. Q. & Paediatric Rheumatology International Trials Organisation, the Childhood Arthritis and Rheumatology Research Alliance, the Pediatric Rheumatology Collaborative Study Group, and the Histiocyte Society, 03.2016, In: ANN RHEUM DIS. 75, 3, p. 481-9 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome
Ammann, S., Schulz, A., Krägeloh-Mann, I., Dieckmann, N. M. G., Niethammer, K., Fuchs, S., Eckl, K. M., Plank, R., Werner, R., Altmüller, J., Thiele, H., Nürnberg, P., Bank, J., Strauss, A., von Bernuth, H., Zur Stadt, U., Grieve, S., Griffiths, G. M., Lehmberg, K., Hennies, H. C. & Ehl, S., 25.02.2016, In: BLOOD. 127, 8, p. 997-1006 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
Ravelli, A., Minoia, F., Davì, S., Horne, A., Bovis, F., Pistorio, A., Aricò, M., Avcin, T., Behrens, E. M., De Benedetti, F., Filipovic, A., Grom, A. A., Henter, J-I., Ilowite, N. T., Jordan, M. B., Khubchandani, R., Kitoh, T., Lehmberg, K., Lovell, D. J., Miettunen, P., Nichols, K. E., Ozen, S., Pachlopnik Schmid, J., Ramanan, A. V., Russo, R., Schneider, R., Sterba, G., Uziel, Y., Wallace, C., Wouters, C., Wulffraat, N., Demirkaya, E., Brunner, H. I., Martini, A., Ruperto, N. & Cron, R. Q., 2016, In: BMJ OPEN. 2, 1, p. e000161Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Unterarmgangrän bei "normaler" Gerinnung.
Blohm, M., Lehmberg, K., Schrum, J., Helmke, K., Ridderbusch, I., Schneppenheim, R. & Singer, D., 2016, In: Z GEBURTSH NEONATOL. 220, p. 133-134Research output: SCORING: Contribution to journal › SCORING: Journal article › Education › peer-review
- 2015
Out of the haemophagocytic lymphohistiocytosis niche
Lehmberg, K., 12.2015, In: LANCET HAEMATOL. 2, 12, p. e508-9Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies
Lehmberg, K., Nichols, K. E., Henter, J-I., Girschikofsky, M., Greenwood, T., Jordan, M., Kumar, A., Minkov, M., La Rosée, P., Weitzman, S. & Study Group on Hemophagocytic Lymphohistiocytosis Subtypes of the Histiocyte Society, 08.2015, In: HAEMATOLOGICA. 100, 8, p. 997-1004 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents
Lehmberg, K., Sprekels, B., Nichols, K. E., Woessmann, W., Müller, I., Suttorp, M., Bernig, T., Beutel, K., Bode, S. F. N., Kentouche, K., Kolb, R., Längler, A., Minkov, M., Schilling, F. H., Schmid, I., Vieth, S., Ehl, S., Zur Stadt, U. & Janka, G. E., 08.2015, In: BRIT J HAEMATOL. 170, 4, p. 539-49 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The syndrome of hemophagocytic lymphohistiocytosis in primary immunodeficiencies: implications for differential diagnosis and pathogenesis
Bode, S. F., Ammann, S., Al-Herz, W., Bataneant, M., Dvorak, C. C., Gehring, S., Gennery, A., Gilmour, K. C., Gonzalez-Granado, L. I., Groß-Wieltsch, U., Ifversen, M., Lingman-Framme, J., Matthes-Martin, S., Mesters, R., Meyts, I., van Montfrans, J. M., Pachlopnik Schmid, J., Pai, S-Y., Soler-Palacin, P., Schuermann, U., Schuster, V., Seidel, M. G., Speckmann, C., Stepensky, P., Sykora, K-W., Tesi, B., Vraetz, T., Waruiru, C., Bryceson, Y. T., Moshous, D., Lehmberg, K., Jordan, M. B., Ehl, S. & Inborn Errors Working Party of the EBMT, 06.2015, In: HAEMATOLOGICA. 100, 7, p. 978-88 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Novel Patient with Late-Onset Familial Hemophagocytic Lymphohistiocytosis with STXBP2 Mutations Presenting with Autoimmune Hepatitis, Neurological Manifestations and Infections Associated with Hypogammaglobulinemia
Esmaeilzadeh, H., Bemanian, M. H., Nabavi, M., Arshi, S., Fallahpour, M., Fuchs, I., Zur Stadt, U., Warnatz, K., Ammann, S., Ehl, S., Lehmberg, K. & Rezaei, N., 01.2015, In: J CLIN IMMUNOL. 35, 1, p. 22-25Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic Arthritis: a multinational, multicenter study of 362 patients
Minoia, F., Davì, S., Horne, A., Demirkaya, E., Bovis, F., Li, C., Lehmberg, K., Weitzman, S., Insalaco, A., Wouters, C., Shenoi, S., Espada, G., Ozen, S., Anton, J., Khubchandani, R., Russo, R., Pal, P., Kasapcopur, O., Miettunen, P., Maritsi, D., Merino, R., Shakoory, B., Alessio, M., Chasnyk, V., Sanner, H., Gao, Y-J., Huasong, Z., Kitoh, T., Avcin, T., Fischbach, M., Frosch, M., Grom, A., Huber, A., Jelusic, M., Sawhney, S., Uziel, Y., Ruperto, N., Martini, A., Cron, R. Q., Ravelli, A. & Pediatric Rheumatology International Trials Organization, 01.11.2014, In: ARTHRITIS RHEUM-US. 66, 11, p. 3160-9 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hemophagocytic lymphohistiocytosis in imported pediatric visceral leishmaniasis in a nonendemic area
Bode, S. F. N., Bogdan, C., Beutel, K., Behnisch, W., Greiner, J., Henning, S., Jorch, N., Jankofsky, M., Jakob, M., Schmid, I., Veelken, N., Vraetz, T., Janka, G., Ehl, S. & Lehmberg, K., 01.07.2014, In: J PEDIATR-US. 165, 1, p. 147-153.e1Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Determination of an appropriate cut-off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis
Lehmberg, K., McClain, K. L., Janka-Schaub, G. & Allen, C. E., 21.04.2014, In: PEDIATR BLOOD CANCER.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hemophagocytic syndromes - An update
Janka-Schaub, G. & Lehmberg, K., 22.03.2014, In: BLOOD REV. 28, 4, p. 135-142Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Treosulfan-based conditioning regimen for children and adolescents with hemophagocytic lymphohistiocytosis
Lehmberg, K., Albert, M. H., Beier, R., Beutel, K., Gruhn, B., Kröger, N-M., Meisel, R., Schulz, A., Stachel, D., Woessmann, W., Janka, G. & Müller, I., 01.01.2014, In: HAEMATOLOGICA. 99, 1, p. 180-4 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Transfer › peer-review
- 2013
Sequential decisions on FAS sequencing guided by biomarkers in patients with lymphoproliferation and autoimmune cytopenia
Rensing-Ehl, A., Janda, A., Lorenz, M. R., Gladstone, B. P., Fuchs, I., Abinun, M., Albert, M., Butler, K., Cant, A., Cseh, A-M., Ebinger, M., Goldacker, S., Hambleton, S., Hebart, H., Houet, L., Kentouche, K., Kühnle, I., Lehmberg, K., Mejstrikova, E., Niemeyer, C., Minkov, M., Neth, O., Dückers, G., Owens, S., Rösler, J., Schilling, F. H., Schuster, V., Seidel, M. G., Smisek, P., Sukova, M., Svec, P., Wiesel, T., Gathmann, B., Schwarz, K., Vach, W., Ehl, S. & Speckmann, C., 01.12.2013, In: HAEMATOLOGICA. 98, 12, p. 1948-55 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Syntaxin binding mechanism and disease-causing mutations in Munc18-2
Hackmann, Y., Graham, S. C., Ehl, S., Höning, S., Lehmberg, K., Aricò, M., Owen, D. J. & Griffiths, G. M., 19.11.2013, In: P NATL ACAD SCI USA. 110, 47, p. E4482-91Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clinical phenotype and functional analysis of a rare XIAP/BIRC4 mutation
Vieth, S., Ammann, S., Schwarz, K., Härtel, C., Schultz, C., Lehmberg, K. & Lauten, M., 01.11.2013, In: KLIN PADIATR. 225, 6, p. 343-6 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
X-linked inhibitor of apoptosis (XIAP) deficiency: the spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis
Speckmann, C., Lehmberg, K., Albert, M. H., Damgaard, R. B., Fritsch, M., Gyrd-Hansen, M., Rensing-Ehl, A., Vraetz, T., Grimbacher, B., Salzer, U., Fuchs, I., Ufheil, H., Belohradsky, B. H., Hassan, A., Cale, C. M., Elawad, M., Strahm, B., Schibli, S., Lauten, M., Kohl, M., Meerpohl, J. J., Rodeck, B., Kolb, R., Eberl, W., Soerensen, J., von Bernuth, H., Lorenz, M., Schwarz, K., zur Stadt, U. & Ehl, S., 01.10.2013, In: CLIN IMMUNOL. 149, 1, p. 133-41 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/MUNC18-2 mutations
Stepensky, P., Bartram, J., Barth, T. F., Lehmberg, K., Walther, P., Amann, K., Philips, A. D., Beringer, O., zur Stadt, U., Schulz, A., Amrolia, P., Weintraub, M., Debatin, K-M., Hoenig, M. & Posovszky, C., 01.07.2013, In: PEDIATR BLOOD CANCER. 60, 7, p. 1215-22 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Differentiating macrophage activation syndrome in systemic juvenile idiopathic arthritis from other forms of hemophagocytic lymphohistiocytosis
Lehmberg, K., Pink, I., zu Eulenburg, C., Beutel, K., Maul-Pavicic, A. & Janka-Schaub, G., 01.06.2013, In: J PEDIATR-US. 162, 6, p. 1245-51 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2
Jessen, B., Bode, S. F. N., Ammann, S., Chakravorty, S., Davies, G., Diestelhorst, J., Frei-Jones, M., Gahl, W. A., Gochuico, B. R., Griese, M., Griffiths, G., Janka-Schaub, G., Klein, C., Kögl, T., Kurnik, K., Lehmberg, K., Maul-Pavicic, A., Mumford, A. D., Pace, D., Parvaneh, N., Rezaei, N., de Saint Basile, G., Schmitt-Graeff, A., Schwarz, K., Karasu, G. T., Zieger, B., zur Stadt, U., Aichele, P. & Ehl, S., 11.04.2013, In: BLOOD. 121, 15, p. 2943-51 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hemophagocytic lymphohistiocytosis - pathogenesis and treatment
Janka-Schaub, G. & Lehmberg, K., 01.01.2013, In: HEMATOL-AM SOC HEMAT. 2013, p. 605-11 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients.
Lehmberg, K., Grosse, R., Muckenthaler, M. U., Altamura, S., Nielsen, P., Schmid, H., Graubner, U., Oyen, F., Zeller, W., Schneppenheim, R. & Janka-Schaub, G., 2013, In: ANN HEMATOL. 92, 3, p. 387-394 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes.
Marsh, R. A., Rao, K., Satwani, P., Lehmberg, K., Müller, I., Li, D., Kim, M-O., Fischer, A., Latour, S., Sedlacek, P., Barlogis, V., Hamamoto, K., Kanegane, H., Milanovich, S., Margolis, D. A., Dimmock, D., Casper, J., Douglas, D. N., Amrolia, P. J., Veys, P., Kumar, A. R., Jordan, M. B., Bleesing, J. J. & Filipovich, A. H., 2013, In: BLOOD. 121, 6, p. 877-883 7 p., 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Diagnostic evaluation of patients with suspected haemophagocytic lymphohistiocytosis.
Lehmberg, K. & Ehl, S., 2013, In: BRIT J HAEMATOL. 160, 3, p. 275-287 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Fulminant Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.
Bohne, S., Kentouche, K., Petersen, I., Fritzenwanger, M., Pletz, M. W., Lehmberg, K., Paul, L. R. & Guntinas-Lichius, O., 2013, In: LARYNGOSCOPE. 123, 2, p. 362-365 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2012
Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5)
Pagel, J., Beutel, K., Lehmberg, K., Koch, F., Maul-Pavicic, A., Rohlfs, A-K., Al-Jefri, A., Beier, R., Lilian, B. O., Ehlert, K., Gross-Wieltsch, U., Jorch, N., Kremens, B., Pekrun, A., Sparber-Sauer, M., Mejstrikova, E., Wawer, A., Ehl, S., Zur Stadt, U. & Janka-Schaub, G., 21.06.2012, In: BLOOD. 119, 25, p. 6016-6024 9 p., 25.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes.
Bryceson, Y. T., Pende, D., Maul-Pavicic, A., Gilmour, K. C., Ufheil, H., Vraetz, T., Chiang, S. C., Marcenaro, S., Meazza, R., Bondzio, I., Walshe, D., Janka-Schaub, G., Lehmberg, K., Beutel, K., Zur Stadt, U., Binder, N., Arico, M., Moretta, L., Henter, J-I. & Ehl, S., 2012, In: BLOOD. 119, 12, p. 2754-2763 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis.
Bode, S. F., Lehmberg, K., Maul-Pavicic, A., Vraetz, T., Janka-Schaub, G., Zur Stadt, U. & Ehl, S., 2012, In: ARTHRITIS RES THER. 14, 3, p. 213 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Risk factors for early death in children with haemophagocytic lymphohistiocytosis.
Trottestam, H., Berglöf, E., Horne, A., Onelöv, E., Beutel, K., Lehmberg, K., Sieni, E., Silfverberg, T., Aricò, M., Janka-Schaub, G. & Henter, J-I., 2012, In: ACTA PAEDIATR. 101, 3, p. 313-318 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.
Jessen, B., Maul-Pavicic, A., Ufheil, H., Vraetz, T., Enders, A., Lehmberg, K., Längler, A., Gross-Wieltsch, U., Bay, A., Kaya, Z., Bryceson, Y. T., Koscielniak, E., Badawy, S., Davies, G., Hufnagel, M., Schmitt-Graeff, A., Aichele, P., Zur Stadt, U., Schwarz, K. & Ehl, S., 2011, In: BLOOD. 118, 17, p. 4620-4629 17.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2009
Pancytopenia in a 4-year-old boy. 22q11.2 microdeletion syndrome.
Lehmberg, K., Rohr, J., Schneppenheim, R., Sommerfeld, K. & Janka-Schaub, G., 2009, In: ACTA PAEDIATR. 98, 5, p. 769-770, 912-914 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2007
From neonates to adolescents--the diagnostic significance of pitted erythrocytes in hyposplenic and asplenic children.
Lehmberg, K., Steinhausen, B. & Janka-Schaub, G., 2007, In: KLIN PADIATR. 219, 6, p. 339-342 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2005
Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells.
Bardenheuer, W., Lehmberg, K., Rattmann, I., Brueckner, A., Schneider, A., Sorg, U. R., Seeber, S., Moritz, T. & Flasshove, M., 2005, In: LEUKEMIA. 19, 12, p. 2281-2288 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review