Prof. Dr. ID: 67850
Franz-Dietmar Kuhl
Publications
- 2022
Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system
Klein, M., Kaleem, A., Oetjen, S., Wünkhaus, D., Binkle, L., Schilling, S., Gjorgjieva, M., Scholz, R., Gruber-Schoffnegger, D., Storch, S., Kins, S., Drewes, G., Hoffmeister-Ullerich, S., Kuhl, D. & Hermey, G., 09.2022, In: AUTOPHAGY. 18, 9, p. 2068-2085 18 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The adaptor protein PICK1 targets the sorting receptor SorLA
Binkle-Ladisch, L., Klein, M., Borgmeyer, U., Kuhl, D. & Hermey, G., 19.02.2022, In: MOL BRAIN. 15, 1, p. 18 18.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2020
Neuronal activity regulates alternative exon usage
Denkena, J., Zaisser, A., Merz, B., Klinger, B., Kuhl, D., Blüthgen, N. & Hermey, G., 10.11.2020, In: MOL BRAIN. 13, 1, p. 148Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
Disturbed Prefrontal Cortex Activity in the Absence of Schizophrenia-Like Behavioral Dysfunction in Arc/Arg3.1 Deficient Mice
Gao, X., Grendel, J., Muhia, M., Castro-Gomez, S., Süsens, U., Isbrandt, D., Kneussel, M., Kuhl, D. & Ohana, O., 09.10.2019, In: J NEUROSCI. 39, 41, p. 8149-8163 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice
Hermey, G., Hoffmeister-Ullerich, S. A., Merz, B., Groß, D., Kuhl, D. & Kins, S., 27.08.2019, In: BIOL CHEM. 400, 9, p. 1181-1189 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice
Schob, C., Morellini, F., Ohana, O., Bakota, L., Hrynchak, M. V., Brandt, R., Brockmann, M. D., Cichon, N., Hartung, H., Hanganu-Opatz, I. L., Kraus, V., Scharf, S., Herrmans-Borgmeyer, I., Schweizer, M., Kuhl, D., Wöhr, M., Vörckel, K. J., Calzada-Wack, J., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., Garner, C. C., Kreienkamp, H-J. & Kindler, S., 16.01.2019, In: TRANSL PSYCHIAT. 9, 1, p. 7Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks
Gao, X., Castro-Gomez, S., Grendel, J., Graf, S., Süsens, U., Binkle, L., Mensching, D., Isbrandt, D., Kuhl, D. & Ohana, O., 04.12.2018, In: P NATL ACAD SCI USA. 115, 49, p. 12531-12536 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling
Voelkl, J., Luong, T. T., Tuffaha, R., Musculus, K., Auer, T., Lian, X., Daniel, C., Zickler, D., Boehme, B., Sacherer, M., Metzler, B., Kuhl, D., Gollasch, M., Amann, K., Müller, D. N., Pieske, B., Lang, F. & Alesutan, I., 02.07.2018, In: J CLIN INVEST. 128, 7, p. 3024-3040 17 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Structural Properties of Synaptic Transmission and Temporal Dynamics at Excitatory Layer 5B Synapses in the Adult Rat Somatosensory Cortex
Rollenhagen, A., Ohana, O., Sätzler, K., Hilgetag, C. C., Kuhl, D. & Lübke, J. H. R., 2018, In: FRONT SYNAPTIC NEURO. 10, p. 24Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
Neuronal activity-regulated alternative mRNA splicing
Hermey, G., Blüthgen, N. & Kuhl, D., 10.2017, In: INT J BIOCHEM CELL B. 91, Pt B, p. 184-193 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SGK1 up-regulates Orai1 expression and VSMC migration during neointima formation after arterial injury
Walker-Allgaier, B., Schaub, M., Alesutan, I., Voelkl, J., Geue, S., Münzer, P., Rodríguez, J. M., Kuhl, D., Lang, F., Gawaz, M. & Borst, O., 03.05.2017, In: THROMB HAEMOSTASIS. 117, 5, p. 1002-1005 4 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Profiling the MAPK/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo
Blüthgen, N., van Bentum, M., Merz, B., Kuhl, D. & Hermey, G., 28.03.2017, In: SCI REP-UK. 7, 45101, p. 1-14Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone
Yang, L., Frindt, G., Lang, F., Kuhl, D., Vallon, V. & Palmer, L. G., 01.01.2017, In: AM J PHYSIOL-RENAL. 312, 1, p. F65-F76Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2016
Revisiting the neuronal localization and trafficking of CLN3 in juvenile neuronal ceroid lipofuscinosis
Oetjen, S., Kuhl, D. & Hermey, G., 01.11.2016, In: J NEUROCHEM. 139, 3, p. 456-470 doi: 10.1111/jnc.13744.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation
Ufer, F., Vargas, P., Engler, J. B., Tintelnot, J., Schattling, B., Winkler, H., Bauer, S., Kursawe, N., Willing, A., Keminer, O., Ohana, O., Salinas-Riester, G., Pless, O., Kuhl, D. & Friese, M. A., 23.09.2016, In: SCI IMMUNOL. 1, 3, p. eaaf8665Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory
Muhia, M., Thies, E., Labonté, D., Ghiretti, A. E., Gromova, K. V., Xompero, F., Lappe-Siefke, C., Hermans-Borgmeyer, I., Kuhl, D., Schweizer, M., Ohana, O., Schwarz, J., Holzbaur, E. L. F. & Kneussel, M., 03.05.2016, In: CELL REP. 15, 5, p. 968-77 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Effects of Arc/Arg3.1 gene deletion on rhythmic synchronization of hippocampal CA1 neurons during locomotor activity and sleep
Malkki, H. A. I., Mertens, P. E. C., Lankelma, J. V., Vinck, M., van Schalkwijk, F. J., van Mourik-Donga, L. B., Battaglia, F. P., Mahlke, C., Kuhl, D. & Pennartz, C. M. A., 05.2016, In: NEUROBIOL LEARN MEM. 131, p. 155-65 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis
Kuipers, S. D., Trentani, A., Tiron, A., Mao, X., Kuhl, D. & Bramham, C. R., 18.02.2016, In: SCI REP-UK. 6, p. 21222Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2015
SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport
Hermey, G., Schmidt, N., Bluhm, B., Mensching, D., Ostermann, K., Rupp, C., Kuhl, D. & Kins, S., 10.2015, In: J NEUROCHEM. 135, 1, p. 60-75 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pivotal role of serum- and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis
Borst, O., Schaub, M., Walker, B., Schmid, E., Münzer, P., Voelkl, J., Alesutan, I., Rodríguez, J. M., Vogel, S., Schoenberger, T., Metzger, K., Rath, D., Umbach, A., Kuhl, F-D., Müller, I. I., Seizer, P., Geisler, T., Gawaz, M. & Lang, F., 01.03.2015, In: ARTERIOSCL THROM VAS. 35, 3, p. 547-57 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lack of the serum- and glucocorticoid-inducible kinase SGK1 improves muscle force characteristics and attenuates fibrosis in dystrophic mdx mouse muscle
Steinberger, M., Föller, M., Vogelgesang, S., Krautwald, M., Landsberger, M., Winkler, C. K., Kasch, J., Füchtbauer, E-M., Kuhl, F-D., Voelkl, J., Lang, F. & Brinkmeier, H., 2015, In: PFLUG ARCH EUR J PHY. 467, 9, p. 1065 - 1974Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
Serum- and glucocorticoid-inducible kinase 1 sensitive NF-κB signaling in dendritic cells
Schmid, E., Xuan, N. T., Zahir, N., Russo, A., Yang, W., Kuhl, F-D., Faggio, C., Shumilina, E. & Lang, F., 2014, In: CELL PHYSIOL BIOCHEM. 34, 3, p. 943-54 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Genome-wide profiling of the activity-dependent hippocampal transcriptome
Hermey, G., Mahlke, C., Gutzmann, J. J., Schreiber, J., Blüthgen, N. & Kuhl, F-D., 01.01.2013, In: PLOS ONE. 8, 10, p. e76903Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Sgk1-dependent stimulation of cardiac Na+/H+ exchanger Nhe1 by dexamethasone
Voelkl, J., Pasham, V., Ahmed, M. S. E., Walker, B., Szteyn, K., Kuhl, F-D., Metzler, B., Alesutan, I. & Lang, F., 01.01.2013, In: CELL PHYSIOL BIOCHEM. 32, 1, p. 25-38 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.
Andres-Mateos, E., Brinkmeier, H., Burks, T. N., Mejias, R., Files, D. C., Steinberger, M., Soleimani, A., Marx, R., Simmers, J. L., Lin, B., Erika, F. H., Marr, T. G., Lin, B. M., Hourdé, C., Leinwand, L. A., Kuhl, D., Föller, M., Vogelsang, S., Hernandez-Diaz, I., Vaughan, D. K., Diego, A. D. L. R., Lang, F. & Cohn, R. D., 2013, In: EMBO MOL MED. 5, 1, p. 80-91 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2012
Sgk1 sensitivity of Na(+)/H(+) exchanger activity and cardiac remodeling following pressure overload.
Voelkl, J., Lin, Y., Alesutan, I., Ahmed, M. S. E., Pasham, V., Mia, S., Gu, S., Feger, M., Saxena, A., Metzler, B., Kuhl, D., Pichler, B. J. & Lang, F., 2012, In: BASIC RES CARDIOL. 107, 2, p. 236 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SGK1 sensitivity of platelet migration.
Schmidt, E-M., Kraemer, B. F., Borst, O., Münzer, P., Schönberger, T., Schmidt, C., Leibrock, C., Towhid, S. T., Seizer, P., Kuhl, D., Stournaras, C., Lindemann, S., Gawaz, M. & Lang, F., 2012, In: CELL PHYSIOL BIOCHEM. 30, 1, p. 259-268 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes.
Borst, O., Schmidt, E-M., Münzer, P., Schönberger, T., Towhid, S. T., Elvers, M., Leibrock, C., Schmid, E., Eylenstein, A., Kuhl, D., May, A. E., Gawaz, M. & Lang, F., 2012, In: BLOOD. 119, 1, p. 251-261 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.
Alberi, L., Liu, S., Wang, Y., Badie, R., Smith-Hicks, C., Wu, J., Pierfelice, T. J., Abazyan, B., Mattson, M. P., Kuhl, D., Pletnikov, M., Worley, P. F. & Gaiano, N., 2011, In: NEURON. 69, 3, p. 437-444 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.
Wu, J., Petralia, R. S., Kurushima, H., Patel, H., Jung, M., Volk, L., Chowdhury, S., Shepherd, J. D., Dehoff, M., Li, Y., Kuhl, D., Huganir, R. L., Price, D. L., Scannevin, R., Troncoso, J. C., Wong, P. C. & Worley, P. F., 2011, In: CELL. 147, 3, p. 615-628 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Arc-dependent synapse-specific homeostatic plasticity.
Béïque, J-C., Na, Y., Kuhl, D., Worley, P. F. & Huganir, R. L., 2011, In: P NATL ACAD SCI USA. 108, 2, p. 816-821 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D.
Rexhepaj, R., Alesutan, I., Gu, S., Pelzl, L., Eichenmüller, M., Pathare, G., Föller, M., Kuhl, D. & Lang, F., 2011, In: PFLUG ARCH EUR J PHY. 462, 3, p. 489-494 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1).
Eylenstein, A., Gehring, E-M., Heise, N., Shumilina, E., Schmidt, S., Szteyn, K., Münzer, P., Nurbaeva, M. K., Eichenmüller, M., Tyan, L., Regel, I., Föller, M., Kuhl, D., Soboloff, J., Penner, R. & Lang, F., 2011, In: FASEB J. 25, 6, p. 2012-2021 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2010
A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex.
Gao, M., Sossa, K., Song, L., Errington, L., Cummings, L., Hwang, H., Kuhl, D., Worley, P. & Lee, H-K., 2010, In: J NEUROSCI. 30, 21, p. 7168-7178 21.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin.
Hossaini, M., Jongen, J. L. M., Biesheuvel, K., Kuhl, D. & Holstege, J. C., 2010, In: MOL PAIN. 6, p. 43Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition.
Cheng, J., Truong, L. D., Wu, X., Kuhl, D., Lang, F. & Du, J., 2010, In: KIDNEY INT. 78, 7, p. 668-678 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SGK1-dependent intestinal tumor growth in APC-deficient mice.
Wang, K., Gu, S., Nasir, O., Föller, M., Ackermann, T. F., Klingel, K., Kandolf, R., Kuhl, D., Stournaras, C. & Lang, F., 2010, In: CELL PHYSIOL BIOCHEM. 25, 2-3, p. 271-278 2-3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells.
Smith-Hicks, C., Xiao, B., Deng, R., Ji, Y., Zhao, X., Shepherd, J. D., Posern, G., Kuhl, D., Huganir, R. L., Ginty, D. D., Worley, P. F. & Linden, D. J., 2010, In: NAT NEUROSCI. 13, 9, p. 1082-1089 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Widespread transcription at neuronal activity-regulated enhancers.
Kim, T-K., Hemberg, M., Gray, J. M., Costa, A. M., Bear, D. M., Wu, J., Harmin, D. A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., Markenscoff-Papadimitriou, E., Kuhl, D., Bito, H., Worley, P. F., Kreiman, G. & Greenberg, M. E., 2010, In: NATURE. 465, 7295, p. 182-187 7295.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2009
Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1.
Vallon, V., Schroth, J., Lang, F., Kuhl, D. & Uchida, S., 2009, In: AM J PHYSIOL-RENAL. 297, 3, p. 704-712 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Fluorescent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo.
Grinevich, V., Kolleker, A., Eliava, M., Takada, N., Takuma, H., Fukazawa, Y., Shigemoto, R., Kuhl, D., Waters, J., Seeburg, P. H. & Osten, P., 2009, In: J NEUROSCI METH. 184, 1, p. 25-36 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC.
Bhandaru, M., Kempe, D. S., Rotte, A., Rexhepaj, R., Kuhl, D. & Lang, F., 2009, In: AM J PHYSIOL-REG I. 297, 3, p. 571-575 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impaired mast cell activation in gene-targeted mice lacking the serum- and glucocorticoid-inducible kinase SGK1.
Sobiesiak, M., Shumilina, E., Lam, R. S., Wölbing, F., Matzner, N., Kaesler, S., Zemtsova, I. M., Lupescu, A., Zahir, N., Kuhl, D., Schaller, M., Biedermann, T. & Lang, F., 2009, In: J IMMUNOL. 183, 7, p. 4395-4402 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pioglitazone induced gastric acid secretion.
Rotte, A., Mack, A. F., Bhandaru, M., Kempe, D. S., Beier, N., Scholz, W., Dicks, E., Pötzsch, S., Kuhl, D. & Lang, F., 2009, In: CELL PHYSIOL BIOCHEM. 24, 3-4, p. 193-200 3-4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Relative resistance of SGK1 knockout mice against chemical carcinogenesis.
Nasir, O., Wang, K., Föller, M., Gu, S., Bhandaru, M., Ackermann, T. F., Boini, K. M., Mack, A., Klingel, K., Amato, R., Perrotti, N., Kuhl, D., Behrens, J., Stournaras, C. & Lang, F., 2009, In: IUBMB LIFE. 61, 7, p. 768-776 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SGK1 dependence of insulin induced hypokalemia.
Boini, K. M., Graf, D., Kuhl, D., Häussinger, D. & Lang, F., 2009, In: PFLUG ARCH EUR J PHY. 457, 4, p. 955-961 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
SGK1-sensitive renal tubular glucose reabsorption in diabetes.
Ackermann, T. F., Boini, K. M., Völkl, H., Bhandaru, M., Bareiss, P. M., Just, L., Vallon, V., Amann, K., Kuhl, D., Feng, Y., Hammes, H-P. & Lang, F., 2009, In: AM J PHYSIOL-RENAL. 296, 4, p. 859-866 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone.
Rexhepaj, R., Rotte, A., Kempe, D. S., Sopjani, M., Föller, M., Gehring, E-M., Bhandaru, M., Gruner, I., Mack, A. F., Rubio-Aliaga, I., Nässl, A-M., Daniel, H., Kuhl, D. & Lang, F., 2009, In: PFLUG ARCH EUR J PHY. 459, 1, p. 191-202 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The serum and glucocorticoid-regulated kinase 1 in hypoxic renal injury.
Rusai, K., Wagner, B., Roos, M., Schmaderer, C., Strobl, M., Boini, K. M., Grenz, A., Kuhl, D., Heemann, U., Lang, F. & Lutz, J., 2009, In: CELL PHYSIOL BIOCHEM. 24, 5-6, p. 577-584 5-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2008
Different motifs regulate trafficking of SorCS1 isoforms.
Nielsen, M. S., Keat, S. J., Hamati, J. W., Madsen, P., Gutzmann, J. J., Engelsberg, A., Pedersen, K. M., Gustafsen, C., Nykjaer, A., Gliemann, J., Hermans-Borgmeyer, I., Kuhl, D., Petersen, C. M. & Hermey, G., 2008, In: TRAFFIC. 9, 6, p. 980-994 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review