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Bioinformatik Core

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Publications

  1. 2017

  2. Mutational landscape reflects the biological continuum of plasma cell dyscrasias

    Rossi, A., Voigtländer, M., Janjetovic, S., Thiele, B., Alawi, M., März, M., Brandt, A., Hansen, T., Radloff, J., Schön, G., Hegenbart, U., Schönland, S., Langer, C., Bokemeyer, C. & Binder, M., 24.02.2017, In: BLOOD CANCER J. 7, 2, p. e537

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Mutations in EBF3 Disturb Transcriptional Profiles and Cause Intellectual Disability, Ataxia, and Facial Dysmorphism

    Harms, F. L., Girisha, K. M., Hardigan, A. A., Kortüm, F., Shukla, A., Alawi, M., Dalal, A., Brady, L., Tarnopolsky, M., Bird, L. M., Ceulemans, S., Bebin, M., Bowling, K. M., Hiatt, S. M., Lose, E. J., Primiano, M., Chung, W. K., Juusola, J., Akdemir, Z. C., Bainbridge, M., Charng, W-L., Drummond-Borg, M., Eldomery, M. K., El-Hattab, A. W., Saleh, M. A. M., Bézieau, S., Cogné, B., Isidor, B., Küry, S., Lupski, J. R., Myers, R. M., Cooper, G. M. & Kutsche, K., 05.01.2017, In: AM J HUM GENET. 100, 1, p. 117-127

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Acute Liver Failure Meets SOPH Syndrome: A Case Report on an Intermediate Phenotype

    Kortüm, F., Marquardt, I., Alawi, M., Korenke, G. C., Spranger, S., Meinecke, P. & Kutsche, K., 01.2017, In: PEDIATRICS. 139, 1, p. pii: e20160550

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Insights into Microalga and Bacteria Interactions of Selected Phycosphere Biofilms Using Metagenomic, Transcriptomic, and Proteomic Approaches

    Krohn-Molt, I., Alawi, M., Förstner, K. U., Wiegandt, A., Burkhardt, L., Indenbirken, D., Thieß, M., Grundhoff, A., Kehr, J., Tholey, A. & Streit, W. R., 2017, In: FRONT MICROBIOL. 8, p. 1941

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. 2016

  7. Versatility of Biofilm Matrix Molecules in Staphylococcus epidermidis Clinical Isolates and Importance of Polysaccharide Intercellular Adhesin Expression during High Shear Stress

    Schaeffer, C. R., Hoang, T-M. N., Sudbeck, C. M., Alawi, M., Tolo, I. E., Robinson, D. A., Horswill, A. R., Rohde, H. & Fey, P. D., 18.10.2016, In: MSPHERE. 1, 5, p. e00165-16.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. De Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype

    Shashi, V., Pena, L. D. M., Kim, K., Burton, B., Hempel, M., Schoch, K., Walkiewicz, M., McLaughlin, H. M., Cho, M., Stong, N., Hickey, S. E., Shuss, C. M., Undiagnosed Diseases Network, Freemark, M. S., Bellet, J. S., Keels, M. A., Bonner, M. J., El-Dairi, M., Butler, M., Kranz, P. G., Stumpel, C. T. R. M., Klinkenberg, S., Oberndorff, K., Alawi, M., Santer, R., Petrovski, S., Kuismin, O., Korpi-Heikkilä, S., Pietilainen, O., Aarno, P., Kurki, M. I., Hoischen, A., Need, A. C., Goldstein, D. B. & Kortüm, F., 06.10.2016, In: AM J HUM GENET. 99, 4, p. 991-999 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Indication of Horizontal DNA Gene Transfer by Extracellular Vesicles

    Fischer, S., Cornils, K., Speiseder, T., Badbaran, A., Reimer, R., Indenbirken, D., Grundhoff, A., Brunswig-Spickenheier, B., Alawi, M. & Lange, C., 30.09.2016, In: PLOS ONE. 11, 9, p. e0163665

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. Correlation of somatic mutations with outcome after FLAMSA-busulfan sequential conditioning and allogeneic stem cell transplantation in patients with MDS

    Christopeit, M., Badbaran, A., Alawi, M., Zabelina, T., Zeck, G., Wolschke, C., Ayuketang, F. A. & Kröger, N., 01.09.2016, In: EUR J HAEMATOL. 97, 3, p. 288-96

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. A novel multiple joint dislocation syndrome associated with a homozygous nonsense variant in the EXOC6B gene

    Girisha, K. M., Kortüm, F., Shah, H., Alawi, M., Dalal, A., Bhavani, G. S. & Kutsche, K., 01.08.2016, In: EUR J HUM GENET. 24, 8, p. 1206-10

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis

    Vogel, M., Velleuer, E., Schmidt-Jiménez, L. F., Mayatepek, E., Borkhardt, A., Alawi, M., Kutsche, K. & Kortüm, F., 07.2016, In: AM J MED GENET A. 170, 7, p. 1813-9 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Pegivirus Infection in Domestic Pigs, Germany

    Baechlein, C., Grundhoff, A., Fischer, N., Alawi, M., Hoeltig, D., Waldmann, K-H. & Becher, P., 07.2016, In: EMERG INFECT DIS. 22, 7, p. 1312-4 3 p.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  14. Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

    Behrens, K., Triviai, I., Schwieger, M., Tekin, N., Alawi, M., Spohn, M., Indenbirken, D., Ziegler, M., Müller, U., Alexander, W. S. & Stocking, C., 30.06.2016, In: BLOOD. 127, 26, p. 3369-81 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma

    Schieferdecker, A., Oberle, A., Thiele, B., Hofmann, F., Göthel, M., Miethe, S., Hust, M., Braig, F., Voigt, M., Pein, U-M., Nolte, F., Haag, F., Alawi, M., Indenbirken, D., Grundhoff, A., Bokemeyer, C., Bacher, U., Kröger, N. & Binder, M., 23.06.2016, In: BLOOD. 127, 25, p. 3202-14

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells

    Berneking, L., Schnapp, M., Rumm, A., Trasak, C., Ruckdeschel, K., Alawi, M., Grundhoff, A., Kikhney, A. G., Nolte, F., Buck, F., Perbandt, M., Betzel, C., Svergun, D. I., Hentschke, M. & Aepfelbacher, M., 13.06.2016, In: PLOS PATHOG. 12, 6, p. e1005660

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage

    Noll, J., Helk, E., Fehling, H., Bernin, H., Marggraff, C., Jacobs, T., Huber, S., Pelczar, P., Ernst, T., Ittrich, H., Otto, B., Mittrücker, H-W., Hölscher, C., Tacke, F., Bruchhaus, I., Tannich, E. & Lotter, H., 05.2016, In: J HEPATOL. 64, 5, p. 1147-57

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Functional dissection of an alternatively spliced herpesvirus gene by splice site mutagenesis

    Schommartz, T., Loroch, S., Alawi, M., Grundhoff, A., Sickmann, A. & Brune, W., 14.04.2016, In: J VIROL. 90, 9, p. 4626-36

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Rapid Capture Next-Generation Sequencing in Clinical Diagnostics of Kinase Pathway Aberrations in B-Cell Precursor ALL

    Stadt, U. Z., Escherich, G., Indenbirken, D., Alawi, M., Adao, M. & Horstmann, M. A., 23.03.2016, In: PEDIATR BLOOD CANCER. 63, 7, p. 1283-6

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  20. Essential control of early B-cell development by Mef2 transcription factors

    Herglotz, J., Unrau, L., Hauschildt, F., Fischer, M., Kriebitzsch, N., Alawi, M., Indenbirken, D., Spohn, M., Müller, U., Ziegler, M., Schuh, W., Jäck, H-M. & Stocking, C., 04.02.2016, In: BLOOD. 127, 5, p. 572-81 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Deep metagenome and metatranscriptome analyses of microbial communities affiliated with an industrial biogas fermenter, a cow rumen, and elephant feces reveal major differences in carbohydrate hydrolysis strategies

    Güllert, S., Fischer, M. A., Turaev, D., Noebauer, B., Ilmberger, N., Wemheuer, B., Alawi, M., Rattei, T., Daniel, R., Schmitz, R. A., Grundhoff, A. & Streit, W. R., 2016, In: BIOTECHNOL BIOFUELS. 9, p. 121

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Systems Medicine as an Emerging Tool for Cardiovascular Genetics

    Haase, T., Börnigen, D., Müller, C. & Zeller, T., 2016, In: FRONT CARDIOVASC MED. 3, p. 27

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  23. 2015

  24. Emergence of daptomycin non-susceptibility in colonizing vancomycin-resistant Enterococcus faecium isolates during daptomycin therapy

    Lellek, H., Franke, G. C., Ruckert, C., Wolters, M., Wolschke, C., Christner, M., Büttner, H., Alawi, M., Kröger, N. & Rohde, H., 12.09.2015, In: INT J MED MICROBIOL. 305, 8, p. 902-909

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence

    Theiss, J. M., Günther, T., Alawi, M., Neumann, F., Tessmer, U., Fischer, N. & Grundhoff, A., 07.2015, In: PLOS PATHOG. 11, 7, p. e1004974

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples

    Fischer, N., Indenbirken, D., Meyer, T., Lütgehetmann, M., Lellek, H., Spohn, M., Aepfelbacher, M., Alawi, M. & Grundhoff, A., 07.2015, In: J CLIN MICROBIOL. 53, 7, p. 2238-50 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. Identification of a Novel Hepacivirus in Domestic Cattle from Germany

    Fischer, N., Baechlein, C., Grundhoff, A., Alawi, M., Indenbirken, D., Postel, A., Baron, A. L., Offinger, J., Becker, K., Beineke, A., Rehage, J. & Becher, P., 07.2015, In: J VIROL. 89, 14, p. 7007-15 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome

    Kortüm, F., Caputo, V., Bauer, C. K., Stella, L., Ciolfi, A., Alawi, M., Bocchinfuso, G., Flex, E., Paolacci, S., Dentici, M. L., Grammatico, P., Korenke, G. C., Leuzzi, V., Mowat, D., Nair, L. D. V., Nguyen, T. T. M., Thierry, P., White, S. M., Dallapiccola, B., Pizzuti, A., Campeau, P. M., Tartaglia, M. & Kutsche, K., 01.06.2015, In: NAT GENET. 47, 6, p. 661-7 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer

    Braig, F., März, M., Schieferdecker, A., Schulte, A., Voigt, M., Stein, A., Grob, T., Alawi, M., Indenbirken, D., Kriegs, M., Engel, E., Vanhoefer, U., Grundhoff, A., Loges, S., Riecken, K., Fehse, B., Bokemeyer, C. & Binder, M., 20.05.2015, In: ONCOTARGET. 6, 14, p. 12035-47 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. Mutations in NDUFB11, Encoding a Complex I Component of the Mitochondrial Respiratory Chain, Cause Microphthalmia with Linear Skin Defects Syndrome

    van Rahden, V. A., Fernandez-Vizarra, E., Alawi, M., Brand, K., Fellmann, F., Horn, D., Zeviani, M. & Kutsche, K., 02.04.2015, In: AM J HUM GENET. 96, 4, p. 640-50 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Deciphering the microRNA signature of pathological cardiac hypertrophy by engineered heart tissue- and sequencing-technology

    Hirt, M. N., Werner, T., Indenbirken, D., Alawi, M., Demin, P., Kunze, A-C., Stenzig, J., Starbatty, J., Hansen, A., Fiedler, J., Thum, T. & Eschenhagen, T., 01.04.2015, In: J MOL CELL CARDIOL. 81, p. 1-9 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Close relationship of ruminant pestiviruses and classical Swine Fever virus

    Postel, A., Schmeiser, S., Oguzoglu, T. C., Indenbirken, D., Alawi, M., Fischer, N., Grundhoff, A. & Becher, P., 04.2015, In: EMERG INFECT DIS. 21, 4, p. 668-72 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts

    Deuse, T., Wang, D., Stubbendorff, M., Itagaki, R., Grabosch, A., Greaves, L. C., Alawi, M., Grünewald, A., Hu, X., Hua, X., Velden, J., Reichenspurner, H., Robbins, R. C., Jaenisch, R., Weissman, I. L. & Schrepfer, S., 08.01.2015, In: CELL STEM CELL. 16, 1, p. 33-38 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. An AP4B1 frameshift mutation in siblings with intellectual disability and spastic tetraplegia further delineates the AP-4 deficiency syndrome

    Abdollahpour, H., Alawi, M., Kortüm, F., Beckstette, M., Seemanova, E., Komárek, V., Rosenberger, G. & Kutsche, K., 2015, In: EUR J HUM GENET. 23, 2, p. 256-259

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. 2014

  36. Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription

    Nagarajan, S., Hossan, T., Alawi, M., Najafova, Z., Indenbirken, D., Bedi, U., Taipaleenmäki, H., Ben-Batalla, I., Scheller, M., Loges, S., Knapp, S., Hesse, E., Chiang, C-M., Grundhoff, A. & Johnsen, S. A., 24.07.2014, In: CELL REP. 8, 2, p. 459-468 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma

    Thiele, B., Kloster, M., Alawi, M., Indenbirken, D., Trepel, M., Grundhoff, A. & Binder, M., 05.06.2014, In: BLOOD. 123, 23, p. 3618-21 4 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. Rapid Metagenomic Diagnostics for Suspected Outbreak of Severe Pneumonia

    Fischer, N., Rohde, H., Indenbirken, D., Günther, T., Reumann, K., Lütgehetmann, M., Meyer, T., Kluge, S., Aepfelbacher, M., Alawi, M. & Grundhoff, A., 01.06.2014, In: EMERG INFECT DIS. 20, 6, p. 1072-5 4 p.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  39. A comparative metagenome survey of the fecal microbiota of a breast- and a plant-fed Asian elephant reveals an unexpectedly high diversity of glycoside hydrolase family enzymes

    Ilmberger, N., Güllert, S., Dannenberg, J., Rabausch, U., Torres, J., Wemheuer, B., Alawi, M., Poehlein, A., Chow, J., Turaev, D., Rattei, T., Schmeisser, C., Salomon, J., Olsen, P. B., Daniel, R., Grundhoff, A., Borchert, M. S. & Streit, W. R., 2014, In: PLOS ONE. 9, 9, p. e106707

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. 2013

  41. Metagenome survey of a multispecies and alga-associated biofilm revealed key elements of bacterial-algal interactions in photobioreactors

    Krohn-Molt, I., Wemheuer, B., Alawi, M., Poehlein, A., Güllert, S., Schmeisser, C., Pommerening-Röser, A., Grundhoff, A., Daniel, R., Hanelt, D. & Streit, W. R., 10.2013, In: APPL ENVIRON MICROB. 79, 20, p. 6196-6206 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer

    Werner, S., Frey, S., Riethdorf, S., Schulze, C., Alawi, M., Kling, L., Vafaizadeh, V., Sauter, G., Terracciano, L., Schumacher, U., Pantel, K. & Assmann, V., 09.08.2013, In: J BIOL CHEM. 288, 32, p. 22993-3008 16 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. Runx1 is essential at two stages of early murine B-cell development

    Niebuhr, B., Kriebitzsch, N., Fischer, M., Behrens, K., Günther, T., Alawi, M., Bergholz, U., Müller, U., Roscher, S., Ziegler, M., Buchholz, F., Grundhoff, A. & Stocking, C., 18.07.2013, In: BLOOD. 122, 3, p. 413-23 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. 2011

  45. CASSys: an integrated software-system for the interactive analysis of ChIP-seq data

    Alawi, M., Kurtz, S. & Beckstette, M., 2011, In: J INTEGR BIOINFORMAT. 8, 2, p. 155

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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