Using autopsies to dissect COVID-19 pathogenesis
Beteiligte Einrichtungen
Abstract
The emergence of SARS-CoV-2 has resulted in millions of deaths as a result of COVID-19. Suitable models were missing at the beginning of the pandemic, and studies investigating disease pathogenesis relied on patients who had succumbed to COVID-19. Since then, autopsies of patients have substantially contributed to our understanding of the pathogenesis of COVID-19 and associated major organ complications. Here we summarize how autopsies have complemented experimental studies, mainly in animal models, and how they have facilitated critical knowledge of COVID-19 to improve daily clinical practice and develop therapeutic interventions. Employing advanced histopathologic and molecular genetic methods in post-mortem tissues, the COVID-19 pandemic has highlighted the importance of autopsies for virology research and clinical practice in current and emerging infectious diseases.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 2058-5276 |
DOIs | |
Status | Veröffentlicht - 05.10.2023 |
Anmerkungen des Dekanats
© 2023. Springer Nature Limited.
PubMed | 37798476 |
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