Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties
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Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties. / Kicha, Alla A.; Ivanchina, Natalia V.; Huong, Trinh T.T.; Kalinovsky, Anatoly I.; Dmitrenok, Pavel S.; Fedorov, Sergey N.; Dyshlovoy, Sergey A.; Long, Pham Q.; Stonik, Valentin A.
in: Bioorganic and Medicinal Chemistry Letters, Jahrgang 20, Nr. 12, 2010, S. 3826-3830.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties
AU - Kicha, Alla A.
AU - Ivanchina, Natalia V.
AU - Huong, Trinh T.T.
AU - Kalinovsky, Anatoly I.
AU - Dmitrenok, Pavel S.
AU - Fedorov, Sergey N.
AU - Dyshlovoy, Sergey A.
AU - Long, Pham Q.
AU - Stonik, Valentin A.
N1 - Funding Information: Financial support was provided by Program of RAS ‘Molecular and Cell Biology’ (MCB RAS) , Grant 09-04-90308-Viet_a from the RFBR , the Vietnam 01-672/QD-KHCNVN Project, FEB RAS Grants 10-III-B-05-018 , 09-III-A-05-146 . The authors are grateful to Dr. Do Cong Thung, VAST, for the identification of the starfish. Copyright: Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P+ Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-κB-transcriptional activations in JB6 Cl41 cells.
AB - New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P+ Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-κB-transcriptional activations in JB6 Cl41 cells.
KW - Archaster typicus
KW - Asterosaponins
KW - Cytotoxic activity
KW - Glycosides
KW - NMR spectra
KW - Starfish
KW - Steroidal aglycons
KW - Sulfates
UR - http://www.scopus.com/inward/record.url?scp=77954213153&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2010.04.005
DO - 10.1016/j.bmcl.2010.04.005
M3 - SCORING: Journal article
C2 - 20493687
AN - SCOPUS:77954213153
VL - 20
SP - 3826
EP - 3830
IS - 12
ER -